Catechol-O-methyltransferase (COMT): Biochemistry, Molecular Biology, Pharmacology, and Clinical Efficacy of the New Selective COMT Inhibitors

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788

Enzymatic O-methylation of epinephrine and other catechols

Axelrod, J., & Tomchick, R. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64731-3 · Cited by 1,283

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

Lotta, T. I., Vidgren, J., Tilgmann, C., Ulmanen, I., Melén, K., Julkunen, I., & Taskinen, J. (1995) · Biochemistry · doi:10.1021/bi00013a008 · Cited by 1,167

Functional role of estrogen metabolism in target cells: review and perspectives

Zhu, B. T. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.1 · Cited by 970

Age at first birth and breast cancer risk.

MacMahon, B., Cole, P. T., Lin, T. M., Lowe, C. R., Mirra, A. P., Ravnihar, B., Salber, E. J., Valaoras, V. G., & Yuasa, S. (1970) · Europe PMC (PubMed Central) · Cited by 878

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

Fotsis, T., Zhang, Y., Pepper, M. S., Adlercreutz, H., Montesano, R., Nawroth, P. P., & Schweigerer, L. (1994) · Nature · doi:10.1038/368237a0 · Cited by 730

Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators

Cavalieri, E. L., Stack, D. E., Devanesan, P. D., Todorović, R., Dwivedy, I., Higginbotham, S. M., Johansson, S. L., Patil, K. D., Gross, M. L., Gooden, J. K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10937 · Cited by 728

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., Walker, N. J., & Sutter, T. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9776 · Cited by 631

Catecholamine metabolism: basic aspects and clinical significance.

Kopin, I. J. (1985) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06859-0 · Cited by 582

Catechol-O-Methyl Transferase: Pharmacological Aspects and Physiological Role

Guldberg, H. C., & Marsden, C. A. (1975) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06681-5 · Cited by 557

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

Klauber, N., Parangi, S., Flynn, E. A., Hamel, E., & D’Amato, R. J. (1997) · PubMed · Cited by 524

Genetic influences on DSMIIIR drug abuse and dependence: A study of 3,372 twin pairs

Tsuang, M. T., Lyons, M. J., Eisen, S. A., Goldberg, J. H., True, W., Lin, N., Meyer, J. M., Toomey, R., Faraone, S. V., & Eaves, L. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960920)67:5 · Cited by 462

Estrogens and breast cancer.

Feigelson, H., & Henderson, B. (1996) · Carcinogenesis · doi:10.1093/carcin/17.11.2279 · Cited by 416

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

D’Amato, R. J., Lin, C. M., Flynn, E. A., Folkman, J., & Hamel, E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3964 · Cited by 407

Crystal structure of catechol O-methyltransferase

Vidgren, J., Svensson, L., & Liljas, A. (1994) · Nature · doi:10.1038/368354a0 · Cited by 403

Bipolar spectrum disorders in patients diagnosed with velo-cardio- facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?

Papolos, D. F., Faedda, G. L., Veit, S., Goldberg, R. B., Morrow, B. E., Kucherlapati, R., & Shprintzen, R. J. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1541 · Cited by 357

Pharmacokinetics of Levodopa

Nutl, J. G., & Fellman, J. H. (1984) · Clinical Neuropharmacology · doi:10.1097/00002826-198403000-00002 · Cited by 357

Carcinogenicity of catechol estrogens in Syrian hamsters

Liehr, J. G., Wan-Fen, F., Sirbasku, D. A., & Ari-Ulubelen, A. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90080-4 · Cited by 356

Genomic organization of the human catechol O‐methyltransferase gene and its expression from two distinct promoters

TENHUNEN, J., SALMINEN, M., LUNDSTRÖM, K., KIVILUOTO, T., SAVOLAINEN, R., & ULMANEN, I. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19083.x · Cited by 331

Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations

Rinne, U. K., Larsen, J. O., Sidén, Å., Worm-Petersen, J., & The Nomecomt Study Group* (1998) · Neurology · doi:10.1212/wnl.51.5.1309 · Cited by 326

Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells

Spink, D. C. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.291 · Cited by 310

Entacapone improves motor fluctuations in levodopa‐ treated Parkinson's disease patients

(1997) · Annals of Neurology · doi:10.1002/ana.410420511 · Cited by 308

Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice

Bradlow, H. L., Michnovicz, J. J., TELANG, N. T., et al. (1991) · Carcinogenesis · doi:10.1093/carcin/12.9.1571 · Cited by 307

Genotype determining low catechol- O -methyltransferase activity as a risk factor for obsessive-compulsive disorder

Karayiorgou, M., Altemus, M., Galke, B. L., Goldman, D., Murphy, D. L., Ott, J., & Gogos, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4572 · Cited by 304

Free radical generation by redox cycling of estrogens

Liehr, J. G., & Roy, D. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90108-u · Cited by 298

Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1→q11.2

Grossman, M. H., Emanuel, B. S., & Budarf, M. L. (1992) · Genomics · doi:10.1016/0888-7543(92)90316-k · Cited by 296

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

Lavigne, J. A., Helzlsouer, K. J., Huang, H. Y., et al. (1997) · PubMed · Cited by 283

Interactions Between Estrogens and Catechol Amines III. Studies on the Methylation of Catechol Estrogens, Catechol Amines and other Catechols by the Catechol-O-Methyltransferase1 of Human Liver

BALL, P., KNUPPEN, R., HAUPT, M., & BREUER, H. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-4-736 · Cited by 280

Estrogen Metabolism and Excretion in Oriental and Caucasian Women

Adlercreutz, H., Gorbach, S. L., Goldin, B. R., Woods, M. N., Dwyer, J. T., & Hämäläinen, E. K. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.14.1076 · Cited by 251

Human liver catechol-O-methyltransferase pharmacogenetics

Boudíková, B., Szumlanski, C. L., Maidak, B. L., & Weinshilboum, R. M. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.166 · Cited by 248

Effect of peripheral catechol‐O‐methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients

Nutt, J. G., Woodward, W. R., Beckner, R. M., Stone, C. K., Berggren, K., Carter, J. H., Gancher, S. T., Hammerstad, J. P., & Gordin, A. (1994) · Neurology · doi:10.1212/wnl.44.5.913 · Cited by 247

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

Weinshilboum, R. M., & Raymond, F. A. (1977) · Europe PMC (PubMed Central) · Cited by 247

Plasma Metanephrines Are Markers of Pheochromocytoma Produced by Catechol- O -Methyltransferase Within Tumors

Eisenhofer, G., Keiser, H. R., Friberg, P., Mezey, É., Huynh, T., Hiremagalur, B., Ellingson, T., Duddempudi, S., Eijsbouts, A. M. M., & Lenders, J. W. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4870 · Cited by 242

Risk factors for breast cancer in Chinese women in Shanghai.

Yuan, J., Yu, M. C., Ross, R. K., Gao, Y., & Henderson, B. E. (1988) · PubMed · Cited by 233

Distribution of adenosine receptors in the postmortem human brain: An extended autoradiographic study

Svenningsson, P., Hall, H., Sedvall, G., & Fredholm, B. B. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199712)27:4 · Cited by 230

“On‐off” phenomenon with levodopa therapy in parkinsonism

Fahn, S. (1974) · Neurology · doi:10.1212/wnl.24.5.431 · Cited by 230

Genotoxic effects of estrogens

Liehr, J. G. (1990) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(90)90018-7 · Cited by 226

Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism.

Jj, L., & Li, S. A. (1987) · PubMed · Cited by 220

Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior

Strous, R. D., Bark, N. M., Parsia, S. S., Volavka, J., & Lachman, H. M. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(96)03111-3 · Cited by 217

Biological Properties of 16α-Hydroxyestrone: Implications in Estrogen Physiology and Pathophysiology*

Fishman, J., & Martucci, C. P. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-611 · Cited by 215

4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis.

Liehr, J. G., Ricci, M. J., Jefcoate, C. R., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9220 · Cited by 210

O-Methylation of Catechol Amines in Vivo

Axelrod, J., Senoh, S., & Witkop, B. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64730-1 · Cited by 207

Tolcapone Improves Motor Function and Reduces Levodopa Requirement in Patients with Parkinson's Disease Experiencing Motor Fluctuations

Kurth, M., Adler, C. H., Saint‐Hilaire, M., Singer, C., Waters, C., LeWitt, P. A., CHERNIK, D. A., Dorflinger, E. E., & Yoo, K. (1997) · Neurology · doi:10.1212/wnl.48.1.81 · Cited by 205

Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.

Thompson, P. A., Shields, P. G., Freudenheim, J. L., et al. (1998) · PubMed · Cited by 203

Association Between Catechol O-Methyltransferase Genotype and Violence in Schizophrenia and Schizoaffective Disorder

Lachman, H. M., Nolan, K. A., Mohr, P., Saito, T., & Volavka, J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.835 · Cited by 198

Dopamine and the Kidney: Ten Years on

Lee, M. R. (1993) · Clinical Science · doi:10.1042/cs0840357 · Cited by 197

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.

Bertocci, B., Miggiano, V., Prada, M. D., Dembić, Z., Lahm, H. W., & Malherbe, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1416 · Cited by 194

Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism

Tiihonen, J., Hallikainen, T., Lachman, H., Saito, T., Volavka, J., Kauhanen, J., Salonen, J. T., Ryynänen, O.-P., Koulu, M., Karvonen, M. K., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000509 · Cited by 189

Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation

Jellinck, P. H., Gekforkert, P., Riddick, D. S., Okey, A. B., Michnovicz, J. J., & Bradlow, H. L. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90258-x · Cited by 188

Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site

Cushman, M., He, H.-M., Katzenellenbogen, J. A., Lin, C. M., & Hamel, E. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00012a003 · Cited by 183

Clearance of Exogenous Dopamine in Rat Dorsal Striatum and Nucleus Accumbens: Role of Metabolism and Effects of Locally Applied Uptake Inhibitors

Cass, W. A., Zahniser, N. R., Flach, K. A., & Gerhardt, G. A. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07469.x · Cited by 173

Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA

LUNDSTR, K., Salminen, M., Jalanko, A., Savolainen, R., & Ulmanen, I. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.181 · Cited by 169

Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors

Männistö, P. T., Ulmanen, I., Lundstrom, K. H., Taskinen, J., Tenhunen, J., Tilgmann, C., & Kaakkola, S. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7144-0_9 · Cited by 168

Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland.

Syvänen, A., Tilgmann, C., Rinne, J., & Ulmanen, I. (1997) · Pharmacogenetics (London) · doi:10.1097/00008571-199702000-00009 · Cited by 168

Tolcapone and fulminant hepatitis

Assal, F., Spahr, L., Hadengue, A., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(05)61511-5 · Cited by 168

Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon: A double-blind, placebo-controlled, multicenter trial

Rajput, A. H., Martin, W. R. W., Saint‐Hilaire, M., Dorflinger, E. E., & Pedder, S. C. J. (1997) · Neurology · doi:10.1212/wnl.49.4.1066 · Cited by 168

Cerebral Metabolism of 6–[ 18 F]Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Primate

Firnau, G., Sood, S. K., Chirakal, R. V., et al. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05629.x · Cited by 167

Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder

Kirov, G., Murphy, K. C., Arranz, M. J., Jones, I. R., McCandles, F., Kunugi, H., Murray, R. M., McGuffin, P., Collier, D. A., Owen, M. J., et al. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000385 · Cited by 167

Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele

Papolos, D. F., Veit, S., Faedda, G. L., Saito, T., & Lachman, H. M. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000410 · Cited by 166

Cytochrome P-450-mediated redox cycling of estrogens.

Liehr, J. G., Ulubelen, A. A., & Strobel, H. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75968-7 · Cited by 161

Catecholoestrogens (2-and 4-hydroxyoestrogens): chemistry, biogenesis, metabolism, occurrence and physiological significance.

Ball, P., & Knüppen, R. (1980) · PubMed · Cited by 157

Catechol- O -Methyltransferase: Thermolabile Enzyme in Erythrocytes of Subjects Homozygous for Allele for Low Activity

Scanlon, P. D., Raymond, F. A., & Weinshilboum, R. M. (1979) · Science · doi:10.1126/science.758679 · Cited by 153

Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone

Nissinen, E., Lindén, I., Schultz, E., et al. (1992) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00173538 · Cited by 148

No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity

Daniels, J. K., Williams, N. M., Williams, J. H., Jones, L. A., Cardno, A. G., Murphy, K. C., Spurlock, G., Riley, B. P., Scambler, P. J., Asherson, P. J., et al. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.268 · Cited by 147

Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression

Ohara, K., Nagai, M., Suzuki, Y., & Ohara, K. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00009 · Cited by 145

The cytotoxic effects of estradiol-17β, catecholestradiols and methoxyestradiols on dividing MCF-7 and Hela cells

Seegers, J. C., Aveling, M.-L., van Aswegen, C. H., et al. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90455-x · Cited by 145

Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors

Bäckström, R., Honkanen, E., Pippuri, A., et al. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00124a017 · Cited by 145

Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations.

Ruottinen, H., & Rinne, U. K. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.1.36 · Cited by 145

Catechol-O-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomenon and levodopa requirements in fluctuating parkinsonian patients

Baas, H. K. J., Beiske, A. G., Ghika, J.-A., Jackson, M., Oertel, W. H., Poewe, W. H., & Ransmayr, G. N. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.4.421 · Cited by 144

Tolcapone in stable Parkinson's disease: Efficacy and safety of long-term treatment

Waters, C., Kurth, M., Bailey, P., et al. (1997) · Neurology · doi:10.1212/wnl.49.3.665 · Cited by 144

The Role of Estrogen in Mammary Carcinogenesisa

Fishman, J., Osborne, M. P., & TELANG, N. T. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb12113.x · Cited by 140

Rationale for Selective COMT Inhibitors as Adjuncts in the Drug Treatment of Parkinson's Disease

Männistö, P. T., & Kaakkola, S. (1990) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1990.tb00756.x · Cited by 139

Contribution of Sulfate Conjugation, Deamination, and O‐Methylation to Metabolism of Dopamine and Norepinephrine in Human Brain

Rivett, A. J., Eddy, B. J., & Roth, J. A. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb11490.x · Cited by 136

Randomized, Placebo-Controlled Study of Tolcapone in Patients With Fluctuating Parkinson Disease Treated With Levodopa-Carbidopa

Adler, C. H. (1998) · Archives of Neurology · doi:10.1001/archneur.55.8.1089 · Cited by 136

Neuropharmacology of S-adenosyl-L-methionine

Baldessarini, R. J. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90860-6 · Cited by 134

Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells.

Lottering, M.-L., Haag, M., & Seegers, J. C. (1992) · PubMed · Cited by 132

Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon

Rajput, A. H., Martin, W. R. W., Saint‐Hilaire, M., Dorflinger, E. E., & Pedder, S. C. J. (1998) · Neurology · doi:10.1212/wnl.50.5_suppl_5.s54 · Cited by 132

Cloning, expression and structure of catechol-O-methyltransferase

Lundstrom, K. H., Tenhunen, J., Tilgmann, C., Karhunen, T., Panula, P., & Ulmanen, I. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(95)00071-2 · Cited by 131

17β-Estradiol 2- and 4-Hydroxylation Catalyzed by Rat Hepatic Cytochrome P-450: Roles of Individual Forms, Inductive Effects, Developmental Patterns, and Alterations by Gonadectomy and Hormone Replacement*

Dannan, G. A., Porubek, D. J., Nelson, S. D., et al. (1986) · Endocrinology · doi:10.1210/endo-118-5-1952 · Cited by 131

Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes

Kerlan, V., Dréano, Y., Bercovici, J. P., Beaune, P. H., Floch, H. H., & Berthou, F. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90068-t · Cited by 129

Membrane-bound catechol-O-methyltransferase: A reevaluation of its role in the O-methylation of the catecholamine neurotransmitters

Roth, J. A. (1992) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0036121 · Cited by 128

General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase

Kaakkola, S., Gordin, A., & Männistö, P. T. (1994) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)90082-5 · Cited by 128

High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease

Kunugi, H., Nanko, S., Ueki, A., Otsuka, E., Hattori, M., Hoda, F., Vallada, H., Arranz, M. J., & Collier, D. A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13289-4 · Cited by 128

Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone

Ker�nen, T., Gordin, A., Karlsson, M., et al. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00199880 · Cited by 127

Preferential transmission of the high activity allele of COMT in schizophrenia

Li, T., Sham, P. C., Vallada, H., Xie, T., Tang, X., Murray, R. M., Liu, X., & Collier, D. A. (1996) · Psychiatric Genetics · doi:10.1097/00041444-199623000-00005 · Cited by 127

A Double-Blind Pharmacokinetic and Clinical Dose—Response Study of Entacapone as an Adjuvant to Levodopa Therapy in Advanced Parkinson's Disease

Ruottinen, H., & Rinne, U. K. (1996) · Clinical Neuropharmacology · doi:10.1097/00002826-199619040-00001 · Cited by 127

[34] Catechol O-methyltransferase

Borchardt, R. T. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77036-8 · Cited by 124

Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase.

Woodard, R. W., Tsai, M., Floss, H. G., et al. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70536-5 · Cited by 122

Distribution of catechol-O-methyltransferase expression in human central nervous system

Hong, J., Shu-Leong, H., Tao, X., & Lap-Ping, Y. (1998) · Neuroreport · doi:10.1097/00001756-199808240-00033 · Cited by 121

Distribution of catechol-O-methyltransferase enzyme in rat tissues.

Karhunen, T., Tilgmann, C., Ulmanen, I., Julkunen, I., & Panula, P. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.8.8027527 · Cited by 120

New selective COMT inhibitors: useful adjuncts for Parkinson's disease?

Männistö, P. T., & Kaakkola, S. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90075-8 · Cited by 119

Molecular cloning and characterization of rat liver catechol-O-methyltransferase

Salminen, M., Lundstrom, K. H., Tilgmann, C., Savolainen, R., Kalkkinen, N., & Ulmanen, I. (1990) · Gene · doi:10.1016/0378-1119(90)90231-f · Cited by 118

Catechol-O-methyltransferase and breast cancer risk

Millikan, R. C. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.1943 · Cited by 118

Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat

Nissinen, E., Lindén, I., Schultz, E., et al. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90614-0 · Cited by 116

Catechol-O-methyltransferase activity: A determinant of levodopa response

Reilly, D. K., Rivera‐Calimlim, L., & Dyke, D. V. (1980) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1980.161 · Cited by 115

Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients

Kaakkola, S., Teräväinen, H., Ahtila, S., et al. (1994) · Neurology · doi:10.1212/wnl.44.1.77 · Cited by 115

Genetics of red cell COMT activity: Analysis of thermal stability and family data

Spielman, R. S., Weinshilboum, R. M., & Opitz, J. M. (1981) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320100311 · Cited by 115

Pharmacokinetic‐pharmacodynamic interaction between the COMT inhibitor tolcapone and single‐dose levodopa.

Dingemanse, J., Jorga, K. M., Zürcher, G., et al. (1995) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1995.tb05781.x · Cited by 114

Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15α,16α,17β-tetrol)

Martucci, C. P., & Fishman, J. (1976) · Steroids · doi:10.1016/0039-128x(76)90054-4 · Cited by 113

Catechol‐O‐methyltransferase‐Inhibiting Pyrocatechol Derivatives: Synthesis and Structure‐Activity Studies

Borgulya, J., Bruderer, H., Bernauer, K., et al. (1989) · Helvetica Chimica Acta · doi:10.1002/hlca.19890720511 · Cited by 113

Effect of L-Dopa and the Catechol-O-Methyltransferase Inhibitor Ro 41–0960 on Sulfur Amino Acid Metabolites in Rats

Miller, J. W., Shukitt‐Hale, B., Villalobos‐Molina, R., et al. (1997) · Clinical Neuropharmacology · doi:10.1097/00002826-199702000-00007 · Cited by 112

Comparative properties of the catechol estrogens, I: Methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors

Merriam, G. R., MacLusky, N. J., Picard, M. K., & Naftolin, F. N. (1980) · Steroids · doi:10.1016/0039-128x(80)90062-8 · Cited by 111

The Effect of Catechol-O-Methyl Transferase Inhibition by Entacapone on the Pharmacokinetics and Metabolism of Levodopa in Healthy Volunteers

Keränen, T., Gordin, A., Harjola, V., et al. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199304000-00007 · Cited by 110

Distinct Cellular Localization of Membrane‐Bound and Soluble Forms of Catechol‐O‐Methyltransferase in Brain

Rivett, A. J., Francis, A., & Roth, J. A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb12673.x · Cited by 109

Catechol‐O‐methyltransferase inhibitor tolcapone prolongs levodopa/carbidopa action in parkinsonian patients

Roberts, J. W., Cora‐Locatelli, G., Bravi, D., et al. (1993) · Neurology · doi:10.1212/wnl.43.12.2685 · Cited by 107

Identification of Sequence Variants and Analysis of the Role of the Catechol-O-Methyl-Transferase Gene in Schizophrenia Susceptibility

Karayiorgou, M., Gogos, J. A., Galke, B. L., Wolyniec, P. S., Nestadt, G., Antonarakis, S. E., Kazazian, H. H., Housman, D. E., & Pulver, A. E. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00202-3 · Cited by 107

Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans*

Dingemanse, J., Jorga, K. M., Schmitt, M., Gieschke, R., Fotteler, B., Zürcher, G., Prada, M. D., & van Brummelen, P. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90035-7 · Cited by 106

No evidence for an association of affective disorders with high- or low-activity allele of catechol-o-methyltransferase gene

Kunugi, H., Vallada, H., Hoda, F., Kirov, G., Gill, M., Aitchison, K. J., Ball, D., Arranz, M. J., Murray, R. M., & Collier, D. A. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00366-6 · Cited by 106

Expression and Intracellular Localization of Catechol O‐methyltransferase in Transfected Mammalian Cells

Ulmanen, I., Peränen, J., Tenhunen, J., Tilgmann, C., Karhunen, T., Panula, P., Bernasconi, L., Aubry, J., & Lundstrom, K. H. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.0452a.x · Cited by 105

No association between anxiety disorders and catechol-O-methyltransferase polymorphism

Ohara, K., Nagai, M., Suzuki, Y., Ochiai, M., & Ohara, K. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00062-6 · Cited by 105

Inhibition of Catechol O-Methyltransferase-catalyzed O-Methylation of 2- and 4-Hydroxyestradiol by Quercetin

Zhu, B. T., & Liehr, J. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1357 · Cited by 105

Cholinergic-dopaminergic interactions in cognitive performance

Levin, E. D., McGurk, S. R., Rose, J. E., & Butcher, L. L. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90639-n · Cited by 102

Cognitive improvement during Tolcapone treatment in Parkinson's disease

Gasparini, M., Fabrizio, E., Bonifati, V., & Meco, G. (1997) · Journal of Neural Transmission · doi:10.1007/bf01285556 · Cited by 98

Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease.

Merello, M., Lees, A. J., Webster, R. A., Bovingdon, M., & Gordin, A. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.2.186 · Cited by 98

Different in vivo properties of three new inhibitors of catechol O‐methyltransferase in the rat

Männistö, P. T., Tuomainen, P. M., & Tuominen, R. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09020.x · Cited by 98

Formation and Clearance of Interstitial Metabolites of Dopamine and Serotonin in the Rat Striatum: An In Vivo Microdialysis Study

Cumming, P. D., Brown, E. E., Damsma, G., & Fibiger, H. C. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11026.x · Cited by 98

Kinetic studies on the O-methylation of dopamine by human brain membrane-bound catechol O-methyltransferase

Rivett, A. J., & Roth, J. A. (1982) · Biochemistry · doi:10.1021/bi00537a006 · Cited by 98

The effect of entacapone (OR‐611) on brain [ 18 F]‐6‐L‐fluorodopa metabolism

Sawle, G. V., Burn, D. J., Morrish, P., et al. (1994) · Neurology · doi:10.1212/wnl.44.7.1292 · Cited by 98

Characterization of Membrane‐Bound and Soluble Catechol‐O‐Methyltransferase from Human Frontal Cortex

Jeffery, D., & Roth, J. A. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02755.x · Cited by 96

Carcinogenic activities of various steroidal and nonsteroidal estrogens in the hamster kidney: relation to hormonal activity and cell proliferation.

Li, J. J., Li, S. A., Oberley, T. D., et al. (1995) · PubMed · Cited by 95

Interactions of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite, with Unpolymerized Tubulin and with Tubulin Polymers

Hamel, E., Lin, C. M., Flynn, E. A., et al. (1996) · Biochemistry · doi:10.1021/bi951559s · Cited by 94

Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics

Ohmori, O., Shinkai, T., Kojima, H., Terao, T., Suzuki, T., Mita, T., & Abe, K. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00100-1 · Cited by 92

Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers

van Aswegen, C. H., Purdy, R. H., & Wittliff, J. L. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90380-4 · Cited by 92

Catechol-O-methyltransferase Vall58Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder

Li, T., Vallada, H., Curtis, D., Arranz, M. J., Xu, K., Cai, G., Deng, H., Liu, J., Murray, R. M., Liu, X., et al. (1997) · Pharmacogenetics · doi:10.1097/00008571-199710000-00002 · Cited by 91

Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans.

Wikberg, T., Vuorela, A., Ottoila, P., et al. (1993) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07341-6 · Cited by 90

Ro 40-7592, a novel, very potent, and orally active inhibitor of catechol-O-methyltransferase: a pharmacological study in rats.

Zürcher, G., Hh, K., Kettler, R., et al. (1990) · PubMed · Cited by 89

The pharmacokinetics of intravenous and oral levodopa in patients with Parkinson's disease who exhibit on‐off fluctuations.

Hardie, R. J., Malcolm, S., Lees, A., et al. (1986) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1986.tb02913.x · Cited by 87

Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study

Kaakkola, S., & Wurtman, R. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91003-w · Cited by 86

Indole‐3‐carbinol

Bradlow, H. L., Sepkovic, D. W., TELANG, N. T., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb12121.x · Cited by 83

No Association between Parkinson's Disease and Low-Activity Alleles of CatecholO-Methyltransferase

Hoda, F., Nicholl, D. J., Bennett, P., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1731 · Cited by 83

Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease

Myllyl�, V. V., Sotaniemi, K. A., Illi, A., et al. (1993) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315512 · Cited by 83

2-METHOXYESTRONE, A NEW METABOLITE OF ESTRADIOL-17β IN MAN

Kraychy, S., & Gallagher, T. F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70636-4 · Cited by 83

The new biology of steroid hormones

(1992) · General and Comparative Endocrinology · doi:10.1016/0016-6480(92)90037-k · Cited by 82

The human catechol-O-methyltransferase (COMT) gene maps to band q11.2 of chromosome 22 and shows a frequent RFLP with BglI

Winqvist, R., Lundstrom, K. H., Salminen, M., Laatikainen, M., & Ulmanen, I. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133262 · Cited by 80

The pharmacology of Parkinson's disease: Basic aspects and recent advances

Prada, M. D., Keller, H. H., Pieri, L., et al. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01946641 · Cited by 78

Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.

McLeod, H. L., Fang, L., Luo, X., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22361-8 · Cited by 78

Importance of Correlated Motions in Forming Highly Reactive Near Attack Conformations in Catechol O-Methyltransferase

Lau, E. Y., & Bruice, T. C. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9827447 · Cited by 77

Ascending afferent regulation of rat midbrain dopamine neurons

Kelland, M. D., Freeman, A. S., Rubin, J. R., & Chiodo, L. A. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90121-q · Cited by 77

The role of monoamine oxidase and catechol O-methyltransferase in dopaminergic neurotransmission.

Napolitano, A., Cesura, A. M., & Prada, M. D. (1995) · PubMed · Cited by 75

Inhibition of COMT induces dopamine-dependent natriuresis and inhibition of proximal tubular Na+,K+-ATPase

Eklöf, A., Holtbäck, U., Sundelöf, M., et al. (1997) · Kidney International · doi:10.1038/ki.1997.390 · Cited by 75

Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein

Karhunen, T., Tilgmann, C., Ulmanen, I., & Panul, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11337-v · Cited by 75

Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues

Zürcher, G., Colzi, A., & Prada, M. D. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9113-2_51 · Cited by 74

Catechol-O-methyltransferase activity in human and rat small intestine

Nissinen, E., Tuominen, R. K., Perhoniemi, V. J., & Kaakkola, S. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90330-x · Cited by 74

Lack of association of functional cathechol-O-methyltransferase gene polymorphism in schizophrenia

Strous, R. D., Bark, N. M., Woerner, M. G., & Lachman, H. M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00474-x · Cited by 74

Structure of the Rat Catechol- O -Methyltransferase Gene: Separate Promoters Are Used to Produce mRNAs for Soluble and Membrane-Bound Forms of the Enzyme

Tenhunen, J., Salminen, M., Jalanko, A., UKKONEN, S., & Ulmanen, I. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.253 · Cited by 74

Catechol-O-methyl Transferase in Epidermis, Dermis and Whole Skin*

Bamshad, J. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.59 · Cited by 73

Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder

Gutiérrez, B., Bertranpetit, J., Guillamat, R., Vallès, V., Arranz, M. J., Kerwin, R., & Fañanás, L. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.1.113 · Cited by 73

Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462

Schultz, E., & Nissinen, E. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90673-4 · Cited by 72

Effect of One Month's Treatment with Peripherally Acting Catechol-O-methyltransferase Inhibitor, Entacapone, on Pharmacokinetics and Motor Response to Levodopa in Advanced Parkinsonian Patients

Ruottinen, H., & Rinne, U. K. (1996) · Clinical Neuropharmacology · doi:10.1097/00002826-199619030-00004 · Cited by 70

Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production

Nissinen, E., Kaheinen, P., Penttilä, K. E., et al. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01431-3 · Cited by 69

Catechol 0-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats

Liljequist, R., Haapalinna, A., Ahlander, M., Li, Y. H., & Männistö, P. T. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)80989-8 · Cited by 69

Difference in erythrocyte catechol-O-methyltransferase activity between Orientals and Caucasians: Difference in levodopa tolerance

Rivera‐Calimlim, L., & Reilly, D. K. (1984) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1984.116 · Cited by 68

Tolcapone

Moreau, J., Borgulya, J., Jenck, F., & Martin, J. R. (1994) · Behavioural Pharmacology · doi:10.1097/00008877-199406000-00012 · Cited by 67

The metabolism of l-DOPA and l-threo-3,4-dihydroxyphenylserine and their effects on monoamines in the human brain: analysis of the intraventricular fluid from parkinsonian patients

Maruyama, W., Naoi, M., & Narabayashi, H. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00049-4 · Cited by 66

Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo

Garris, P. A., & Wightman, R. M. (1995) · Synapse · doi:10.1002/syn.890200311 · Cited by 66

Effects of Catechol‐O‐Methyltransferase Inhibitors and L‐3,4‐Dihydroxyphenylalanine With or Without Carbidopa on Extracellular Dopamine in Rat Striatum

Kaakkola, S., & Wurtman, R. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05831.x · Cited by 66

Striatal membrane-bound and soluble catechol-O-methyl-transferase after selective neuronal lesions in the rat

Kaakkola, S., M�nnist�, P. T., & Nissinen, E. (1987) · Journal of Neural Transmission · doi:10.1007/bf01244343 · Cited by 65

Extracellular Concentrations of Dopamine and Metabolites in the Rat Caudate After Oral Administration of a Novel Catechol‐O‐Methyltransferase Inhibitor Ro 40–7592

Acquas, E., Carboni, E., de Ree, R. H. A., et al. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08907.x · Cited by 64

The Clinical Picture and Plasma Levodopa Metabolite Profile of Parkinsonian Nonresponders

Rivera‐Calimlim, L. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500160042007 · Cited by 64

Ethnic differences in catechol O-methyltransferase pharmacogenetics: frequency of the codon 108/158 low activity allele is lower in Kenyan than Caucasian or South-west Asian individuals.

McLeod, H. L., Syvänen, A.-C., Githanga, J. N., et al. (1998) · PubMed · Cited by 64

The metabolism of L‐3–0‐methyldopa, aprecursor of dopa in man

Kuruma, I., Bartholini, G., Tissot, R., et al. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971124678 · Cited by 64

Potentiation of the l-Dopa effect in man by the use of catechol-O-methyltransferase inhibitors

Ericsson, A. (1971) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(71)90088-8 · Cited by 63

Multiple-dose clinical pharmacology of the catechol- O -methyl-transferase inhibitor tolcapone in elderly subjects

Dingemanse, J., Jorga, K. M., Zürcher, G., et al. (1996) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050068 · Cited by 63

Bioactive 6-Nitronorepinephrine Identified in Mammalian Brain

Shintani, F., Kinoshita, T., Kanba, S., ISHIKAWA, T., Suzuki, E., Sasakawa, N., Kato, R., Asai, M., & Nakaki, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13561 · Cited by 63

Oestradiol 16 alpha-hydroxylase: a risk marker for breast cancer.

Bradlow, H. L., Re, H., & Jf, F. (1986) · PubMed · Cited by 61

Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs

Tenhunen, J., & Ulmanen, I. (1993) · Biochemical Journal · doi:10.1042/bj2960595 · Cited by 59

Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase

Männistö, P. T., Kaakkola, S., Nissinen, E., et al. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90258-5 · Cited by 58

Tolcapone added to levodopa in stable parkinsonian patients: A double‐blind placebo‐controlled study

Dupont, E., Burgunder, J., Findley, L. J. J., et al. (1997) · Movement Disorders · doi:10.1002/mds.870120615 · Cited by 58

Graphical analysis of 6-fluoro-L-dopa trapping: effect of inhibition of catechol-O-methyltransferase.

Holden, J. E., Doudet, D. J., Endres, C. J., Chan, G. L.-Y., Morrison, K., Vingerhoets, F. J. G., Snow, B. J., Pate, B. D., Sossi, V., Buckley, K. R., et al. (1997) · PubMed · Cited by 58

The clinical picture

Lee, R. V. (1990) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(90)90142-c · Cited by 57

Behavioural and neurochemical effects of Ro 40-7592, a new COMT inhibitor with a potential therapeutic activity in Parkinson's disease

Maj, J., Rogóż, Z., Skuza, G., et al. (1990) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260898 · Cited by 57

Effect of Entacapone, a COMP Inhibitor, on the Pharmacokinetics and Metabolism of Levodopa After Administration of Controlled-Release Levodopa-Carbidopa in Volunteers

Ahtila, S., Kaakkola, S., Gordin, A., et al. (1995) · Clinical Neuropharmacology · doi:10.1097/00002826-199502000-00006 · Cited by 55

Metabolites of 6-[18F]fluoro-L-dopa in human blood.

Firnau, G., Sood, S. K., Chirakal, R. V., et al. (1988) · PubMed · Cited by 55

High-performance liquid chromatography separation of hydroxylated estradiol metabolites: formation of estradiol metabolites by liver microsomes from male and female rats.

Suchar, L. A., Chang, R. L., Rosen, R. T., et al. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24305-1 · Cited by 54

Structure-Based Drug Design

Codding, P. W. (1998) · Springer eBooks · doi:10.1007/978-94-015-9028-0 · Cited by 54

Fluorodopa Positron Emission Tomography with an Inhibitor of Catechol- O -Methyltransferase: Effect of the Plasma 3- O -Methyldopa Fraction on Data Analysis

Ishikawa, T., DHAWAN, V. M., Chaly, T., et al. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00010 · Cited by 53

Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan

Yoritaka, A., Hattori, N., Yoshino, H., et al. (1997) · Journal of Neural Transmission · doi:10.1007/bf01294732 · Cited by 53

The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS—II. Fractionation and quantitation of the main groups of estrogen conjugates

Fotsis, T. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90380-3 · Cited by 53

Simultaneous MAO‐B and COMT inhibition in L ‐dopa‐treated patients with parkinson's disease

Lyytinen, J., Kaakkola, S., Ahtila, S., Tuomainen, P. M., & Teräväinen, H. (1997) · Movement Disorders · doi:10.1002/mds.870120404 · Cited by 52

Ontogenic aspects of liver and kidney catechol‐O‐ methyltransferase sensitivity to tolcapone

Vieira‐Coelho, M. A., & Soares-da-Silva, P. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15220.x · Cited by 52

Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo

Waldmeier, P. C., Buchle, A.-M., & Steulet, A.-F. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90222-i · Cited by 51

Expression of recombinant soluble and membrane‐bound catechol O‐methyltransferase in eukaryotic cells and identification of the respective enzymes in rat brain

Tilgmann, C., Melén, K., Lundstrom, K. H., Jalanko, A., Julkunen, I., Kalkkinen, N., & Ulmanen, I. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17112.x · Cited by 50

Potent COMT inhibition by Ro 40-7592 in the periphery and in the brain. Preclinical and clinical findings.

Zürcher, G., Dingemanse, J., & Prada, M. D. (1993) · PubMed · Cited by 50

The effect of estradiol on catechol-O-methyltransferase activity in rat liver

Cohn, C. K., & Axelrod, J. (1971) · Life Sciences · doi:10.1016/0024-3205(71)90335-3 · Cited by 49

Metabolism of Catecholamines by Catechol‐O‐Methyltransferase in Cells Expressing Recombinant Catecholamine Transporters

Eshleman, A. J., Stewart, E., Evenson, A. K., et al. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041459.x · Cited by 49

Monooxygenase Mediating Catecholestrogen Formation by Rot Anterior Pituitary is an Estrogen-4-Hydroxylose

Bui, Q. D., Neisz, J., & Hershey, M. S. (1989) · Endocrinology · doi:10.1210/endo-124-2-1085 · Cited by 48

G/A1947 polymorphism in catechol‐O‐methyltransferase (COMT) gene in Parkinson's disease

Xie, T., Ho, S. L., Li, L. S. W., & Ma, O. C. K. (1997) · Movement Disorders · doi:10.1002/mds.870120325 · Cited by 48

Antioxidant properties of nitecapone (OR-462)

Suzuki, Y., Tsuchiya, M., Safadi, A., Kagan, V. E., & Packer, L. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90146-8 · Cited by 47

Mammalian small molecule methyltransferases: Their structural and functional features

Fujioka, M. (1992) · International Journal of Biochemistry · doi:10.1016/0020-711x(92)90287-b · Cited by 47

Catechol-O-methyltransferase in vitiligo

Poole, I. C. L., van den Wijngaard, R. M. J. G. J., Smit, N. P. M., et al. (1994) · Archives of Dermatological Research · doi:10.1007/bf00370732 · Cited by 47

Acute Administration of Levodopa-Benserazide and Tolcapone, a COMT Inhibitor, in Parkinsonʼs Disease

Limousin, P. D., Pollak, P., Pfefen, J. P., et al. (1995) · Clinical Neuropharmacology · doi:10.1097/00002826-199506000-00006 · Cited by 47

A pilot evaluation of the tolerability, safety, and efficacy of tolcapone alone and in combination with oral selegiline in untreated Parkinson's disease patients

Hauser, R. A., Molho, E., Shale, H. M., et al. (1998) · Movement Disorders · doi:10.1002/mds.870130406 · Cited by 47

The carcinogenic activity of ethinyl estrogens is determined by both their hormonal characteristics and their conversion to catechol metabolites.

Zhu, B. T., Roy, D., & Liehr, J. G. (1993) · Endocrinology · doi:10.1210/endo.132.2.8381068 · Cited by 47

[ 18 F]‐6‐Fluorodopa PET scanning in Parkinson's disease after selective COMT inhibition with nitecapone (OR‐462)

Laihinen, A., Rinne, J. O., Rinne, U. K., et al. (1992) · Neurology · doi:10.1212/wnl.42.1.199 · Cited by 46

Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake

Budygin, E. A., Gainetdinov, R. R., Kilpatrick, M., et al. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00084-9 · Cited by 46

Radioimmunoassay of 2-hydroxyestrone

Ball, P., Emons, G., Haupt, O., et al. (1978) · Steroids · doi:10.1016/0039-128x(78)90117-4 · Cited by 46

Effect of a Novel Catechol-O-Methyltransferase Inhibitor, Nitecapone, on the Metabolism of l-Dopa in Healthy Volunteers

Kaakkola, S., Gordin, A., Järvinen, M., et al. (1990) · Clinical Neuropharmacology · doi:10.1097/00002826-199010000-00005 · Cited by 46

Expression of Functional Membrane‐Bound and Soluble Catechol‐O‐Methyltransferase in Escherichia coli and a Mammalian Cell Line

Malherbe, P., Bertocci, B., Caspers, P., Zürcher, G., & Prada, M. D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10054.x · Cited by 45

Regional brain kinetics of 6-fluoro-(?-11C)-L-dopa and (?-11C)-L-dopa following COMT inhibition. A study in vivo using positron emission tomography

Hartvig, P., Lindner, K., Tedroff, J., et al. (1992) · Journal of Neural Transmission · doi:10.1007/bf01253107 · Cited by 45

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction

Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409

Understanding the contribution of synonymous mutations to human disease

Sauna, Z. E., & Kimchi-Sarfaty, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3051 · Cited by 1,022

Catechol O -methyltransferase val 158 -met genotype and individual variation in the brain response to amphetamine

Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860

A sensitive radioenzymatic assay for catechol drugs

Durrett, L. R., & Ziegler, M. G. (1980) · Journal of Neuroscience Research · doi:10.1002/jnr.490050613 · Cited by 98

An Abnormal Methylation Ratio Induces Hypomethylation In Vitro in the Brain of Pig and Man, But Not in Rat

McKeever, M., Molloy, A. M., Weir, D. G., et al. (1995) · Clinical Science · doi:10.1042/cs0880073 · Cited by 32

Methylation of phytohormones by the SABATH methyltransferases

Qu, L., Li, S., & Xing, S. (2010) · Chinese Science Bulletin · doi:10.1007/s11434-010-3245-x · Cited by 17

Structural Insights of Outer Membrane Protein Methyltransferases from Rickettsia

Abeykoon, A. H., Noinaj, N., Chao, C., et al. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.561.7

A semiempirical study on inhibition of catechol O-methyltransferase by substituted catechols

Ovaska, M., & Yliniemelä, A. (1998) · Journal of Computer-Aided Molecular Design · doi:10.1023/a:1007965026738 · Cited by 17