The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

Fatemi, S. H.; Folsom, T. D.

doi:10.1093/schbul/sbn187

Cited by 860Schizophrenia research and treatmentTryptophan and brain disordersMental Health and Psychiatry

The Neurodevelopmental Hypothesis of Schizophrenia, Revisited

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Fatemi, S. H., Folsom, T. D.·2009·Schizophrenia Bulletin

DOI 10.1093/schbul/sbn187PMC PMC2669580

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Abstract

While multiple theories have been put forth regarding the origin of schizophrenia, by far the vast majority of evidence points to the neurodevelopmental model in which developmental insults as early as late first or early second trimester lead to the activation of pathologic neural circuits during adolescence or young adulthood leading to the emergence of positive or negative symptoms. In this report, we examine the evidence from brain pathology (enlargement of the cerebroventricular system, changes in gray and white matters, and abnormal laminar organization), genetics (changes in the normal expression of proteins that are involved in early migration of neurons and glia, cell proliferation, axonal outgrowth, synaptogenesis, and apoptosis), environmental factors (increased frequency of obstetric complications and increased rates of schizophrenic births due to prenatal viral or bacterial infections), and gene-environmental interactions (a disproportionate number of schizophrenia candidate genes are regulated by hypoxia, microdeletions and microduplications, the overrepresentation of pathogen-related genes among schizophrenia candidate genes) in support of the neurodevelopmental model. We relate the neurodevelopmental model to a number of findings about schizophrenia. Finally, we also examine alternate explanations of the origin of schizophrenia including the neurodegenerative model.

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Symptoms of schizophrenia do not manifest fully until late adolescence.
“symptoms do not manifest fully until late adolescence.1”
From Adolescent Onset of Cortical Disinhibition in Schizophrenia: Insights From Animal Models (2011) · cites this paper as [1]

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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Clozapine for the Treatment-Resistant Schizophrenic: A Double-blind Comparison With Chlorpromazine
Kane, J. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800330013001 · Cited by 4,156 · see citing works
Pharmacological Reviews
(2024) · Pharmacological Reviews · doi:10.1124/pr · Cited by 2,680 · see citing works
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works
Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain
Carlsson, A., & Lindqvist, M. (1963) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1963.tb01730.x · Cited by 2,156 · see citing works
Apoptosis in the nervous system
Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,862 · see citing works
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800 · see citing works
Meta-analysis of regional brain volumes in schizophrenia
Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W. R., David, A. S., Murray, R. M., & Bullmore, E. T. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.16 · Cited by 1,662 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Rare chromosomal deletions and duplications increase risk of schizophrenia
The International Schizophrenia Consortium (2008) · Nature · doi:10.1038/nature07239 · Cited by 1,475 · see citing works
Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort
JONES, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90569-x · Cited by 1,353 · see citing works
Schizophrenia and migration: A meta-analysis and review
Cantor-Graae, E., & Selten, J.-P. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.12 · Cited by 1,237 · see citing works
Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder
Guidotti, A., Auta, J., Davis, J. M., Gerevini, V. D. G., Dwivedi, Y., Grayson, D. R., Impagnatiello, F., Pandey, G. N., Pesold, C., Sharma, R. P., et al. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1061 · Cited by 1,203 · see citing works
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
Mednick, S. A. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800260109013 · Cited by 1,198 · see citing works
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192 · see citing works
Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review
Cannon, M. D., Jones, P. B., & Murray, R. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1080 · Cited by 1,138 · see citing works
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Lewis, C. M., Levinson, D. F., Wise, L. H., DeLisi, L. E., Straub, R. E., Hovatta, I., Williams, N. M., Schwab, S. G., Pulver, A. E., Faraone, S. V., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/376549 · Cited by 1,134 · see citing works
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082 · see citing works
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors
Männistö, P. T., & Kaakkola, S. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01423-6 · Cited by 1,068 · see citing works
Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.774 · Cited by 1,048 · see citing works
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025 · see citing works
Self-citation
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
The neurodevelopmental model of schizophrenia: update 2005
Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993 · see citing works
Early manifestations and first-contact incidence of schizophrenia in different cultures: A preliminary report on the initial evaluation phase of the WHO Collaborative Study on Determinants of Outcome of Severe Mental Disorders
Sartorius, N., Jablensky, A., Korten, A., Ernberg, G., Anker, M., Cooper, J. E., & Day, R. (1986) · Psychological Medicine · doi:10.1017/s0033291700011910 · Cited by 959 · see citing works
The Schizophrenia-like Psychoses of Epilepsy
Slater, E. T. O., & Beard, A. (1963) · The British Journal of Psychiatry · doi:10.1192/bjp.109.458.95 · Cited by 958 · see citing works
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Tkachev, D., Mimmack, M., Ryan, M. M., Wayland, M., Freeman, T., Jones, P., Starkey, M., Webster, M., Yolken, R., & Bahn, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14289-4 · Cited by 940 · see citing works
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938 · see citing works
Causal association between cannabis and psychosis: examination of the evidence
Arseneault, L., Cannon, M. D., Witton, J., & Murray, R. M. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.184.2.110 · Cited by 909 · see citing works
Atypical antipsychotics: Mechanism of action
Seeman, P. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204700106 · Cited by 899 · see citing works
Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex
Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00085-4 · Cited by 882 · see citing works
Sex Differences in the Risk of Schizophrenia: Evidence From Meta-analysis
Aleman, A., Kahn, R. S., & Selten, J.-P. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.565 · Cited by 818 · see citing works
Antipsychotic Drug Effects on Brain Morphology in First-Episode Psychosis
Lieberman, J. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.361 · Cited by 804 · see citing works
White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction
Davis, K. L., Stewart, D. G., Friedman, J. I., Buchsbaum, M., Harvey, P. D., Hof, P. R., Buxbaum, J., & Haroutunian, V. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.443 · Cited by 793 · see citing works
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 753 · see citing works
Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema
Papadopoulos, M. C., Manley, G. T., Krishna, S., & Verkman, A. S. (2004) · The FASEB Journal · doi:10.1096/fj.04-1723fje · Cited by 749 · see citing works
Schizophrenia After Prenatal Famine
Susser, E. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830010027005 · Cited by 741 · see citing works
Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development
Akbarian, S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150007001 · Cited by 679 · see citing works
Late-Onset Schizophrenia and Very-Late-Onset Schizophrenia-Like Psychosis: An International Consensus
Howard, R., Rabins, P. V., Seeman, M. V., Jeste, D. V., & Late-Onset, T. I. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.2.172 · Cited by 678 · see citing works
Half a century of antipsychotics and still a central role for dopamine D2 receptors
Kapur, S., & Mamo, D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.004 · Cited by 638 · see citing works
A Unitary Model of Schizophrenia
Andreasen, N. C. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.9.781 · Cited by 609 · see citing works
Genes for schizophrenia? Recent findings and their pathophysiological implications
Harrison, P. J., & Owen, M. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12379-3 · Cited by 597 · see citing works
The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection.
Hillier, S. L., Witkin, S. S., Krohn, M. A., Watts, D. H., Kiviat, N. B., & Eschenbach, D. A. (1993) · PubMed · Cited by 581 · see citing works
Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Hahn, C.-G., Wang, H.-Y., Cho, D.-S., Talbot, K., Gur, R. E., Berrettini, W. H., Bakshi, K. P., Kamins, J., Borgmann‐Winter, K. E., Siegel, S. J., et al. (2006) · Nature Medicine · doi:10.1038/nm1418 · Cited by 564 · see citing works
Prenatal Infection as a Risk Factor for Schizophrenia
Brown, A. S. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj052 · Cited by 540 · see citing works
Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia
Arnold, S. E. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310043008 · Cited by 525 · see citing works
Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia
DeLisi, L. E., Sakuma, M., Tew, W. P., Kushner, M., Hoff, A. L., & GRIMSON, R. C. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00012-7 · Cited by 512 · see citing works
Evidence for Abnormal Cortical Functional Connectivity During Working Memory in Schizophrenia
Meyer‐Lindenberg, A., Poline, J., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1809 · Cited by 507 · see citing works
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works
Is schizophrenia a neurodegenerative disorder? a clinical and neurobiological perspective
Lieberman, J. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00147-x · Cited by 486 · see citing works
Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice
Meyer, U., Nyffeler, M., Yee, B. K., Knuesel, I., & Feldon, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.09.012 · Cited by 457 · see citing works
A review of longitudinal studies of cognitive functions in schizophrenia patients
Rund, B. R. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033337 · Cited by 451 · see citing works
Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Lim, K. O., Hedehus, M., Moseley, M. E., de Crespigny, A. J., Sullivan, E. V., & Pfefferbaum, A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.367 · Cited by 447 · see citing works
Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression
Fatemi, S. H., Earle, J. A., & McMenomy, T. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000783 · Cited by 447 · see citing works
Self-citation
Catechol-O-Methyltransferase Inhibition Improves Set-Shifting Performance and Elevates Stimulated Dopamine Release in the Rat Prefrontal Cortex
Tunbridge, E. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1124-04.2004 · Cited by 418 · see citing works
Delayed-Onset Hypothesis of Antipsychotic Action: A Hypothesis Tested and Rejected
Agid, O., Kapur, S., Arenovich, T., & Zipursky, R. B. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1228 · Cited by 408 · see citing works
Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, and fetal brain
Urakubo, A., Jarskog, L. F., Lieberman, J. A., & Gilmore, J. H. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00032-3 · Cited by 405 · see citing works
Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia
Rapoport, J. L., Giedd, J. N., Blumenthal, J. D., Hamburger, S., Jeffries, N. O., Fernandez, T., Nicolson, R., Bedwell, J. S., Lenane, M., Zijdenbos, A. P., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.7.649 · Cited by 388 · see citing works
Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia
Karlsson, H., Bachmann, S., Schröder, J., McArthur, J. C., Torrey, Ε. F., & Yolken, R. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061021998 · Cited by 378 · see citing works
Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376 · see citing works
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
Buchsbaum, M., Tang, C. Y., Peled, S., Gudbjartsson, H., Lu, D.-F., Hazlett, E., Downhill, J., Haznedar, M., Fallon, J., & Atlas, S. (1998) · NeuroReport · doi:10.1097/00001756-199802160-00013 · Cited by 369 · see citing works
Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect
Fish, B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030053007 · Cited by 357 · see citing works
3‐Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple Two Pool Model
Karoum, F., Chrapusta, S. J., & Egan, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030972.x · Cited by 347 · see citing works
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
Burns, J., Job, D., Bastin, M. E., Whalley, H., Macgillivray, T., Johnstone, E. C., & Lawrie, S. M. (2003) · British Journal of Psychiatry · doi:10.1192/bjp.182.5.439 · Cited by 327 · see citing works
Late-onset Schizophrenia: An Overview
Harris, M. J., & Jeste, D. V. (1988) · Schizophrenia Bulletin · doi:10.1093/schbul/14.1.39 · Cited by 322 · see citing works
Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies
Niemi, L. T., Suvisaari, J., Tuulio‐Henriksson, A., & Lönnqvist, J. K. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00234-7 · Cited by 321 · see citing works
Tumor Necrosis Factor Alpha, Interleukin 1 and Related Cytokines in Brain Development: Normal and Pathological
Merrill, J. E. (1992) · Developmental Neuroscience · doi:10.1159/000111642 · Cited by 317 · see citing works
Maternal Cytokine Levels during Pregnancy and Adult Psychosis
Buka, S. L., Tsuang, M. T., Torrey, E. F., Klebanoff, M. A., Wagner, R., & Yolken, R. H. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0644 · Cited by 316 · see citing works
Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study
Foong, J. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.2.242 · Cited by 316 · see citing works
Three distinct roles of aquaporin-4 in brain function revealed by knockout mice
Verkman, A. S., Binder, D. K., Bloch, O. G., Auguste, K. I., & Papadopoulos, M. C. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.02.018 · Cited by 312 · see citing works
Schizophrenia: genes at last?
Owen, M. J., Craddock, N. J., & O’Donovan, M. C. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.06.011 · Cited by 308 · see citing works
Prenatal Immune Challenge Disrupts Sensorimotor Gating in Adult Rats Implications for the Etiopathogenesis of Schizophrenia
Borrell, J. I. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00360-8 · Cited by 307 · see citing works
DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains
Veldić, M., Caruncho, H. J., Liu, W. S., Davis, J. M., Satta, R., Grayson, D. R., Guidotti, A., & Costa, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637013100 · Cited by 303 · see citing works
GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
Fatemi, S. H., Stary, J. M., Earle, J. A., Araghi‐Niknam, M., & Eagan, E. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.02.017 · Cited by 300 · see citing works
Self-citation
Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia
Sweet, R. A., Henteleff, R. A., Zhang, W., Sampson, A. R., & Lewis, D. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.67 · Cited by 290 · see citing works
Prenatal Nutritional Deficiency and Risk of Adult Schizophrenia
Brown, A. S., & Susser, E. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn096 · Cited by 290 · see citing works
Genomic Rearrangements and Gene Copy-Number Alterations as a Cause of Nervous System Disorders
Lee, J. A., & Lupski, J. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.027 · Cited by 289 · see citing works
Schizophrenia and velo-cardio-facial syndrome
Murphy, K. C. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07604-3 · Cited by 284 · see citing works
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
Garcia, R. A. G., Vasudevan, K., & Buonanno, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3596 · Cited by 278 · see citing works
Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study
Vawter, M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00377-2 · Cited by 275 · see citing works
Development, disease and degeneration in schizophrenia: a unitary pathophysiological model
Keshavan, M. S. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00033-3 · Cited by 272 · see citing works
Fetal Hypoxia and Structural Brain Abnormalities in Schizophrenic Patients, Their Siblings, and Controls
Cannon, T. D., van Erp, T. G. M., Rosso, I. M., HUTTUNEN, M. O., Lönnqvist, J. K., Pirkola, T., Salonen, O. L. M., Valanne, L. K., Poutanen, V.-P., & Standertskjöld-Nordenstam, C.-G. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.1.35 · Cited by 266 · see citing works
The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia
Bullmore, E. T., Frangou, S., & Murray, R. M. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00114-x · Cited by 265 · see citing works
Schizophrenia After Prenatal Famine
van Os, J. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830180095015 · Cited by 264 · see citing works
Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia
Fatemi, S. H., Earle, J., Kanodia, R., Kist, D., Emamian, E. S., Patterson, P. H., Shi, L., & Sidwell, R. (2002) · Cellular and Molecular Neurobiology · doi:10.1023/a:1015337611258 · Cited by 261 · see citing works
Self-citation
Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry
Weinberger, D. R., & McClure, R. K. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.553 · Cited by 261 · see citing works
Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice
Fatemi, S. H., Emamian, E. S., Kist, D. A., Sidwell, R. W., Nakajima, K., Akhter, P., Shier, A. C., Sheikh, S. A., & Bailey, K. W. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000520 · Cited by 259 · see citing works
Self-citation
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
Liu, G., Beggs, H. E., Jürgensen, C., Park, H.-T., Tang, H., Gorski, J. A., Jones, K. R., Reichardt, L. F., Wu, J. Y., & Rao, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1331 · Cited by 259 · see citing works
Decreased Somal Size of Deep Layer 3 Pyramidal Neurons in the Prefrontal Cortex of Subjects With Schizophrenia
Pierri, J. N., Volk, C. L. E., Auh, S., Sampson, A., & Lewis, D. A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.466 · Cited by 257 · see citing works
Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Huang, H., Oishi, K., Mori, S., Smee, D. F., Pearce, D. A., Winter, C., Sohr, R., et al. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.11.018 · Cited by 250 · see citing works
Self-citation
Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice
Fidel, P. L., Romero, R. J., Wolf, N. A., Cutright, J. L., Ramírez, M., Araneda, H., & Cotton, D. B. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(94)70180-6 · Cited by 249 · see citing works
Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density
Chana, G., Landau, S., Beasley, C. L., Everall, I., & Cotter, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00114-8 · Cited by 245 · see citing works
MRI study of white matter diffusion anisotropy in schizophrenia
Ardekani, B. A., Nierenberg, J. J., Hoptman, M. J., Javitt, D. C., & Lim, K. O. (2003) · Neuroreport · doi:10.1097/00001756-200311140-00004 · Cited by 244 · see citing works
Reelin glycoprotein: structure, biology and roles in health and disease
Fatemi, S. H. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001613 · Cited by 241 · see citing works
Self-citation
Neuropsychiatric applications of DTI – a review
Lim, K. O., & Helpern, J. A. (2002) · NMR in Biomedicine · doi:10.1002/nbm.789 · Cited by 226 · see citing works
Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study
Agartz, I., Andersson, J., & Skare, S. T. (2001) · Neuroreport · doi:10.1097/00001756-200107200-00041 · Cited by 225 · see citing works
Nonaffective Psychosis After Prenatal Exposure to Rubella
Brown, A. S., Cohen, P., Greenwald, S., & Susser, E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.438 · Cited by 219 · see citing works
Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., Babulas, V. P., & Susser, E. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000151642.60544.d2 · Cited by 216 · see citing works
Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia
Walker, E. F. (1994) · Schizophrenia Bulletin · doi:10.1093/schbul/20.3.453 · Cited by 216 · see citing works
Apoptotic mechanisms in the pathophysiology of schizophrenia
Jarskog, L. F., Glantz, L. A., Gilmore, J. H., & Lieberman, J. A. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.010 · Cited by 214 · see citing works
Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia
Bunney, W. E. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00031-4 · Cited by 212 · see citing works
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cellsPreprint
Kondo, T., & RAFF, M. C. (2004) · Genes & Development · doi:10.1101/gad.309404 · Cited by 212 · see citing works
The Evolution of Drug Development in Schizophrenia: Past Issues and Future Opportunities
Carpenter, W. T., & Koenig, J. I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301639 · Cited by 210 · see citing works
Recent advances in defining the neuropathology of schizophrenia
Arnold, S. E., & Trojanowski, J. Q. (1996) · Acta Neuropathologica · doi:10.1007/s004010050512 · Cited by 205 · see citing works
Apoptotic Proteins in the Temporal Cortex in Schizophrenia: High Bax/Bcl-2 Ratio Without Caspase-3 Activation
Jarskog, L. F., Selinger, E. S., Lieberman, J. A., & Gilmore, J. H. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.109 · Cited by 205 · see citing works
Brain maturational processes and delayed onset in schizophrenia
Keshavan, M. S., & Hogarty, G. E. (1999) · Development and Psychopathology · doi:10.1017/s0954579499002199 · Cited by 202 · see citing works
Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development
Gadient, R. A., & Otten, U. (1994) · Brain Research · doi:10.1016/0006-8993(94)91211-4 · Cited by 195 · see citing works
Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk
Nicodemus, K. K., Marenco, S., Batten, A. J., Vakkalanka, R., Egan, M. F., Straub, R. E., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002153 · Cited by 192 · see citing works
Expression of Excitatory Amino Acid Transporter Transcripts in the Thalamus of Subjects With Schizophrenia
Smith, R. E., Haroutunian, V. H., Davis, K. L., & Meador‐Woodruff, J. H. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1393 · Cited by 190 · see citing works
An MRI study of cerebellar vermis morphology in patients with schizophrenia: evidence in support of the cognitive dysmetria concept
Nopoulos, P., Ceilley, J. W., Gailis, E. A., & Andreasen, N. C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00093-1 · Cited by 184 · see citing works
The American Psychiatric Press Textbook of Psychiatry.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-508_13 · Cited by 178 · see citing works
Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments
Paylor, R. E. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.23.2645 · Cited by 170 · see citing works
Prenatal Influenza Infections and Adult Schizophrenia
Mednick, S. A., HUTTUNEN, M. O., & Machón, R. A. (1994) · Schizophrenia Bulletin · doi:10.1093/schbul/20.2.263 · Cited by 169 · see citing works
Season of Birth: Schizophernia and Bipolar Disorder
Boyd, J., Pulver, A. E., & Stewart, W. F. (1986) · Schizophrenia Bulletin · doi:10.1093/schbul/12.2.173 · Cited by 166 · see citing works
Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia
Ritter, L. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00086-0 · Cited by 166 · see citing works
Rhesus Incompatibility as a Risk Factor for Schizophrenia in Male Adults
Hollister, J. M. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830010021004 · Cited by 163 · see citing works
Cortical Bcl-2 protein expression and apoptotic regulation in schizophrenia
Jarskog, L. F., Gilmore, J. H., Selinger, E. S., & Lieberman, J. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00988-4 · Cited by 162 · see citing works
Time Course for Antipsychotic Treatment Response in First-Episode Schizophrenia
Emsley, R. A., Rabinowitz, J., & Medori, R. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.4.743 · Cited by 162 · see citing works
Hematolymphopoietic and inflammatory cytokines in neural development
Mehler, M. F., & Kessler, J. A. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01045-4 · Cited by 160 · see citing works
Maternal influenza, obstetric complications, and schizophrenia
Wright, P., Takei, N., Rifkin, L., & Murray, R. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.12.1714 · Cited by 159 · see citing works
Aripiprazole: A Novel Atypical Antipsychotic Drug With a Uniquely Robust Pharmacology
Davies, M. A., Sheffler, D. J., & Roth, B. L. (2004) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2004.tb00030.x · Cited by 158 · see citing works
Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: A potential animal model for schizophrenia and autism
Fatemi, S. H., Pearce, D. A., Brooks, A. I., & Sidwell, R. W. (2005) · Synapse · doi:10.1002/syn.20162 · Cited by 151 · see citing works
Self-citation
Investigating regional white matter in schizophrenia using diffusion tensor imaging
Foong, J., Symms, M. R., Barker, G. J., Maier, M., Miller, D. H., & Ron, M. A. (2002) · Neuroreport · doi:10.1097/00001756-200203040-00017 · Cited by 150 · see citing works
Heritability of Brain Morphology Related to Schizophrenia: A Large-Scale Automated Magnetic Resonance Imaging Segmentation Study
Goldman, A. L., Pezawas, L., Mattay, V. S., Fischl, B. R., Verchinski, B. A., Zoltick, B. J., Weinberger, D. R., & Meyer‐Lindenberg, A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.006 · Cited by 150 · see citing works
The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology
Eastwood, S. L., Law, A. J., Everall, I., & Harrison, P. J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001233 · Cited by 144 · see citing works
Inflammatory cytokine (interleukins 1, 6, and 8 and tumor necrosis factor-α) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations
Fortunato, S. J., Menon, R., Swan, K. F., & Menon, R. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70221-1 · Cited by 144 · see citing works
Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia
Schmidt‐Kastner, R., van Os, J., Steinbusch, H. W. M., & Schmitz, C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.022 · Cited by 143 · see citing works
Schizophrenia and Other Psychotic Disorders
Jibson, M. D., Glick, I. D., & Tandon, R. (2004) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.2.1.17 · Cited by 140 · see citing works
The American Psychiatric Publishing Textbook of Schizophrenia
(2007) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318033a46f · Cited by 138 · see citing works
Towards understanding the schizophrenia code: an expanded convergent functional genomics approach
Le‐Niculescu, H., Balaraman, Y., Patel, S., Tan, J., Sidhu, K., Jerome, R. E., Edenberg, H. J., Kuczenski, R., Geyer, M. A., Nurnberger, J. I., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30481 · Cited by 137 · see citing works
Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii
Carter, C. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn054 · Cited by 137 · see citing works
Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients
Perron, H., Mékaoui, L., Bernard, C., Veas, F., Stefas, I., & Leboyer, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.028 · Cited by 131 · see citing works
Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300
Kitagawa, M., Lee, S. H., & McCormick, F. P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.036 · Cited by 129 · see citing works
Expression of inflammatory cytokines (interleukin-1β and interleukin-6) in amniochorionic membranes
Menon, R., Swan, K. F., LYDEN, T. W., Rote, N. S., & Fortunato, S. J. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90562-6 · Cited by 128 · see citing works
Second-trimester markers of fetal size in schizophrenia: a study of monozygotic twins
Bracha, H. S., Torrey, E. F., Gottesman, I. I., et al. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.10.1355 · Cited by 125 · see citing works
Anterior and posterior hippocampal volumes in schizophrenia
Weiss, A. P., DeWitt, I., GOFF, D. C., Ditman, T., & Heckers, S. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.05.018 · Cited by 125 · see citing works
Cellular and Molecular Neuropathology of the Parahippocampal Region in Schizophrenia
Arnold, S. E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06732.x · Cited by 122 · see citing works
Genetic Case-Control Association Studies in Neuropsychiatry
Sullivan, P. F. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1015 · Cited by 120 · see citing works
Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation
Zuckerman, L., & Weiner, I. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1461-7 · Cited by 119 · see citing works
Progression of cerebroventricular enlargement and the subtyping of schizophrenia
Nair, T. R., Christensen, J. D., Kingsbury, S. J., Kumar, N. G., Terry, W., & Garver, D. L. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00013-9 · Cited by 116 · see citing works
Common Pattern of Cortical Pathology in Childhood-Onset and Adult-Onset Schizophrenia as Identified by Proton Magnetic Resonance Spectroscopic Imaging
Bertolino, A., Kumra, S., Callicott, J. H., Mattay, V. S., Lestz, R. M., Jacobsen, L. K., Barnett, L. S., Duyn, J. H., Frank, J. A., Rapoport, J. L., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1376 · Cited by 116 · see citing works
Partial Dopamine Agonists and Dopaminergic Stabilizers, in the Treatment of Psychosis
Tamminga, C. A., & Carlsson, A. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007024606195 · Cited by 115 · see citing works
Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories
Addington, A. M., Gornick, M. C., Shaw, P., Seal, J., Gogtay, N., GREENSTEIN, D. K., CLASEN, L. S., Coffey, M., Gochman, P., Long, R. T. L., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001906 · Cited by 109 · see citing works
Prenatal viral infection causes alterations in nNOS expression in developing mouse brains
Fatemi, S. H., Cuadra, A. E., El‐Fakahany, E. E., Sidwell, R. W., & THURAS, P. D. (2000) · Neuroreport · doi:10.1097/00001756-200005150-00027 · Cited by 109 · see citing works
Self-citation
The Interaction of Seasonality, Place of Birth, Genetic Risk and Subsequent Schizophrenia in a High Risk Sample
Machón, R. A., Mednick, S. A., & Schulsinger, F. (1983) · The British Journal of Psychiatry · doi:10.1192/bjp.143.4.383 · Cited by 109 · see citing works
Gene Expression Profiling with DNA Microarrays: Advancing Our Understanding of Psychiatric Disorders
Pongrac, J. L., Middleton, F. A., Lewis, D. A., Levitt, P. R., & Mirnics, K. (2002) · Neurochemical Research · doi:10.1023/a:1020904821237 · Cited by 108 · see citing works
The association of inequality with the incidence of schizophrenia
Boydell, J. E., van Os, J., McKenzie, K. J., & Murray, R. M. (2004) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-004-0789-6 · Cited by 107 · see citing works
Altered Expression of Genes Involved in GABAergic Transmission and Neuromodulation of Granule Cell Activity in the Cerebellum of Schizophrenia Patients
Bullock, W. M., Cardon, K. E., Bustillo, J., Roberts, R. C., & Perrone‐Bizzozero, N. I. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07121845 · Cited by 106 · see citing works
Neurological soft signs and minor physical anomalies in patients with schizophrenia and related disorders, their first-degree biological relatives, and non-psychiatric controls
Compton, M. T., Bollini, A. M., Mack, L. M., et al. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.04.002 · Cited by 106 · see citing works
Brain Metabolite Abnormalities in the White Matter of Elderly Schizophrenic Subjects: Implication for Glial Dysfunction
Chang, L., Friedman, J. I., Ernst, T., Zhong, K., Tsopelas, N. D., & Davis, K. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.025 · Cited by 101 · see citing works
Making the Case for a Candidate Vulnerability Gene in Schizophrenia: Convergent Evidence for Regulator of G-Protein Signaling 4 (RGS4)
Levitt, P. R., Ebert, P. J., Mirnics, K., Nimgaonkar, V. L., & Lewis, D. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.028 · Cited by 101 · see citing works
Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families
Wedenoja, J., Loukola, A., Tuulio‐Henriksson, A., Paunio, T., Ekelund, J., Silander, K., Varilo, T., Heikkila, K. V., Suvisaari, J., Partonen, T., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002047 · Cited by 101 · see citing works
Chronic Olanzapine Treatment Causes Differential Expression of Genes in Frontal Cortex of Rats as Revealed by DNA Microarray Technique
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Bell, C., Nos, L., Fried, P., Pearce, D. A., Singh, S., Siderovski, D. P., Willard, F. S., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301002 · Cited by 96 · see citing works
Self-citation
Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation
Kumari, V., Gray, J. A., Honey, G. D., Soni, W., Bullmore, E. T., Williams, S., Ng, V., Vythelingum, G. N., Simmons, A., John Suckling, A., et al. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00270-5 · Cited by 93 · see citing works
Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test - a fMRI study
Riehemann, S., Volz, H., Stützer, P., Smesny, S., Christian Gaser, B., & Sauer, H. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170055 · Cited by 93 · see citing works
Volumetric abnormalities associated with cognitive deficits in patients with schizophrenia
Wolf, R. C., Höse, A., Frasch, K., Walter, H., & Vasić, N. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2008.02.002 · Cited by 87 · see citing works
Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene
Buxbaum, J. D., Georgieva, L., Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y., Moskvina, V, Norton, N., Peirce, T., Williams, H., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4001991 · Cited by 86 · see citing works
Reviewing the Role of DNA (Cytosine-5) Methyltransferase Overexpression in the Cortical GABAergic Dysfunction Associated with Psychosis Vulnerability
Dong, E., Grayson, D. R., Guidotti, A., Ruzicka, W. B., Veldić, M., & Costa, E. (2007) · Epigenetics · doi:10.4161/epi.2.1.4063 · Cited by 84 · see citing works
Apoptosis and microglial activation in influenza encephalopathy
Nakai, Y., Itoh, M., Mizuguchi, M., Ozawa, H., Okazaki, E., Kobayashi, Y., Takahashi, M., Ohtani, K., Ogawa, A., Narita, M., et al. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0605-x · Cited by 81 · see citing works
Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy
Aronsson, F. S., Lannebo, C., Paucar, M., Brask, J., Kristensson, K., & Karlsson, H. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100480 · Cited by 77 · see citing works
cDNA microarray and proteomic approaches in the study of brain diseases: focus on schizophrenia and Alzheimer's disease
Marcotte, E. R., Srivastava, L. K., & Quirion, R. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00086-x · Cited by 75 · see citing works
Testing models of thalamic dysfunction in schizophrenia using neuroimaging
Sim, K., Cullen, T. J., Öngür, D., & Heckers, S. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0363-8 · Cited by 75 · see citing works
Developmental expression of cytokine genes in the cortex and hippocampus of the rat central nervous system
Pousset, F. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90078-7 · Cited by 74 · see citing works
Altered gene expression in the superior temporal gyrus in schizophrenia
Bowden, N. A., Scott, R. J., & Tooney, P. A. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-199 · Cited by 74 · see citing works
Acute-phase cytokines IL-1β and TNF-α in brain development
Dzięgielewska, K. M., Møller, J. E., Potter, A., Ek, C. J., Lane, M. A., & Saunders, N. R. (2000) · Cell and Tissue Research · doi:10.1007/s004419900157 · Cited by 74 · see citing works
HUMAN FIRST TRIMESTER FOREBRAIN CELLS EXPRESS GENES FOR INFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
Mousa, A., Seiger, Å., Kjældgaard, A., et al. (1999) · Cytokine · doi:10.1006/cyto.1998.0381 · Cited by 71 · see citing works
Catching up on schizophrenia: natural history and neurobiology.
Lewis, D. A., & Lieberman, J. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)00111-2 · Cited by 71 · see citing works
Differences in the fetal interleukin-6 response to microbial invasion of the amniotic cavity between term and preterm gestation
Yoon, B. H., Romero, R. J., Moon, J. M., Chaiworapongsa, T., Espinoza, J., Kim, Y. M., Edwin, S. S., Kim, J. C., Camacho, N., Bujold, E., et al. (2003) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/jmf.13.1.32.38 · Cited by 71 · see citing works
Schizophrenia in Late Life: Findings Challenge Traditional Concepts
Palmer, B. W., McClure, F. S., & Jeste, D. V. (2001) · Harvard Review of Psychiatry · doi:10.1080/10673220127883 · Cited by 70 · see citing works
Midsagittal cortical pathomorphology of schizophrenia: A magnetic resonance imaging study
Masayuki, U., & Kaiya, H. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90167-4 · Cited by 70 · see citing works
The role of cerebellar genes in pathology of autism and schizophrenia
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., & Sidwell, R. W. (2008) · The Cerebellum · doi:10.1007/s12311-008-0017-0 · Cited by 68 · see citing works
Self-citation
The Presence of Neurological Soft Signs Along the Psychosis Proneness Continuum
Barkus, E., Stirling, J., Hopkins, R., & Lewis, S. W. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj037 · Cited by 68 · see citing works
The New York high-risk project: social and general intelligence in children at risk for schizophrenia
Ott, S. L., Spinelli, S., Rock, D., Roberts, S. A., Amminger, G. P., & Erlenmeyer‐Kimling, L. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00010-3 · Cited by 67 · see citing works
Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship?
Boog, G. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2003.09.041 · Cited by 65 · see citing works
Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene
Chung, C., Tallerico, T., & Seeman, P. M. (2003) · Synapse · doi:10.1002/syn.10228 · Cited by 62 · see citing works
Searching for schizophrenia genes
Bray, N. J., & Owen, M. J. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)01950-5 · Cited by 59 · see citing works
Invasion and Persistence of the Neuroadapted Influenza Virus A/WSN/33 in the Mouse Olfactory System
Aronsson, F. S., Robertson, B. J., Ljunggren, H., et al. (2003) · Viral Immunology · doi:10.1089/088282403322396208 · Cited by 57 · see citing works
Microarray Analysis of Differentially Expressed Genes in Rat Frontal Cortex Under Chronic Risperidone Treatment
Chen, M., & Chen, C. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300612 · Cited by 56 · see citing works
Developmental Regulation of Cytokine Expression in the Mouse Brain
Burns, T. M., Clough, J. A., Klein, R. M., Wood, G. W., & Berman, N. E. J. (1993) · Growth Factors · doi:10.3109/08977199308991585 · Cited by 55 · see citing works
Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
Colantuoni, C., Hyde, T. M., Mitkus, S. N., Joseph, A., Sartorius, L. J., Aguirre, C., Creswell, J., Johnson, E., Deep‐Soboslay, A., Herman, M. M., et al. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0181-5 · Cited by 54 · see citing works
The role of maternal infectious diseases during pregnancy in the etiology of schizophrenia in offspring
Stöber, G., Franzek, E., & Beckmann, H. (1992) · European Psychiatry · doi:10.1017/s0924933800005241 · Cited by 54 · see citing works
Risk for obstetric complications and schizophrenia
Preti, A., Cardascia, L., Zen, T., Marchetti, M., Favaretto, G., & Miotto, P. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00185-2 · Cited by 53 · see citing works
Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity
Lloyd, T., Dazzan, P., Dean, K., Park, S. B. G., Fearon, P., Doody, G. A., Tarrant, J., Morgan, K. D., Morgan, C., Hutchinson, G. A., et al. (2007) · Psychological Medicine · doi:10.1017/s0033291707001158 · Cited by 49 · see citing works
Schizophrenia: Prenatal Influenza and Autoimmunity
Wright, P., & Murray, R. M. (1993) · Annals of Medicine · doi:10.3109/07853899309147318 · Cited by 43 · see citing works
Growth Factor Regulation of Neuronal Development
Mehler, M. F., & Kessler, J. A. (1994) · Developmental Neuroscience · doi:10.1159/000112105 · Cited by 41 · see citing works
Excess Seasonality of Births Among Patients With Schizophrenia and Seasonal Ovopathy
Pallast, E., Jongbloet, P. H., Straatman, H., & Zielhuis, G. A. (1994) · Schizophrenia Bulletin · doi:10.1093/schbul/20.2.269 · Cited by 41 · see citing works
Abnormally persistent latent inhibition induced by lesions to the nucleus accumbens core, basolateral amygdala and orbitofrontal cortex is reversed by clozapine but not by haloperidol
Schiller, D., ZUCKERMAN, L., & Weiner, I. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.03.002 · Cited by 40 · see citing works
A study of hippocampal shape anomaly in schizophrenia and in families multiply affected by schizophrenia or bipolar disorder
Connor, S. E. J., Ng, V., McDonald, C., Schulze, K., Morgan, K. D., Dazzan, P., & Murray, R. M. (2004) · Neuroradiology · doi:10.1007/s00234-004-1224-0 · Cited by 40 · see citing works
Neurodevelopmental Interactions Conferring Risk for Schizophrenia: A Study of Dermatoglyphic Markers in Patients and Relatives
Avila, M. T., Sherr, J. D., Valentine, L., et al. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007031 · Cited by 40 · see citing works
Cortical sulcal enlargement in catatonic schizophrenia: a planimetric CT study
Northoff, G., Waters, H., Mooren, I., Schlüter, U., Diekmann, S., Falkai, P., & Bogerts, B. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00024-4 · Cited by 39 · see citing works
Hippocampal CA4 Reelin-positive neurons
Fatemi, S. H., Earle, J. A., & McMenomy, T. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000794 · Cited by 39 · see citing works
Self-citation
Genes and subtypes of schizophrenia
Mirnics, K., & Lewis, D. A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02067-6 · Cited by 38 · see citing works
Viral infection of developing GABAergic neurons in a model of hippocampal disinhibition
Pearce, B. D., Valadi, N. M., Po, C. L., & Miller, A. H. (2000) · Neuroreport · doi:10.1097/00001756-200008030-00019 · Cited by 37 · see citing works
Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin
Fatemi, S. H., Folsom, T. D., Reutiman, T. J., & Sidwell, R. W. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.031 · Cited by 37 · see citing works
Self-citation
Prenatal Exposures in Schizophrenia
Lindenmayer, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.5.831-a · Cited by 33 · see citing works
Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice
Aronsson, F. S. (2001) · Journal of NeuroVirology · doi:10.1080/13550280152058771 · Cited by 33 · see citing works
Agreement between face-to-face and telephone-administered mood ratings in patients with rapid cycling bipolar disorder
Feldman‐Naim, S., Myers, F. S., Clark, C. H., et al. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(97)00044-9 · Cited by 30 · see citing works
Retroviruses and the pathogenesis of schizophrenia
Lewis, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081075898 · Cited by 30 · see citing works
Genetics and Schizophrenia
Riley, B. P., Asherson, P. J., & McGuffin, P. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch14 · Cited by 28 · see citing works
Season of Birth of Siblings of Schizophrenic Patients
Pulver, A. E., Liang, K., Wolyniec, P. S., et al. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.1.71 · Cited by 27 · see citing works
Changes in calcium currents and GABAergic spontaneous activity in cultured rat hippocampal neurons after a neurotropic influenza A virus infection
Brask, J., Owe‐Larsson, B., Hill, R. H., & Kristensson, K. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00536-6 · Cited by 25 · see citing works

Flagged first, then by citations

Research works printed but not linked: 7

Gilmore JH, Murray RM. Prenatal and perinatal factors. In: Lieberman JA, Stroup TS, Perkins DO, eds. The American Psychiatric Publishing Textbook of Schizophrenia. Washing- ton, DC: American Psychiatric Publishing Inc.; 2006:55-68.
Mednick SA, Machon RA, Huttunen MO. Adult schizo- phrenia following prenatal exposure to an influenza epi- demic. Arch Gen Psychiatry. 1988;45:189-192.
Stober G, Franzek E, Beckmann J. The role of maternal in- fectious diseases during pregnancy in the aetiology of schizo- phrenia in offspring. Eur Psychiatry. 1992;7:147-152.
Chen BY, Chang HH, Chiou HL, Lin DP. Influenza B virus-induced brain malformations during early chick em- bryogenesis and localization of tRNA in specific areas. J Biomed Sci. 2004;11:266-274.
McDuffie RS, Dabies JK, Leslie KK, Sherman MP, Gibbs RS. A randomized control trail of interleukin-1 receptor antago- nist in a rabbit model of ascending infection in pregnancy. Infect Dis Obstet Gynecol. 2001;9:233-237.
Susser E, Neugebauer R, Hoek HW, et al. Schizophrenia af- ter prenatal famine. Further evidence. Arch Gen Psychiatry. 1996;53:25-31.
Sullivan PF, Owen MJ, O'Donovan MC, Freedman MD. Genetics. In: Lieberman JA, Stroup TS, Perkins DO, eds. The American Psychiatric Publishing Textbook of Schizo- phrenia. Washington, DC: American Psychiatric Publishing Inc; 2006:39-54.

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Dysconnectivity in schizophrenia: where are we now?
Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., & Mechelli, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.004 · Cited by 712 · see citing works
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“Thus, circuits tend to be malleable but vulnerable during postnatal development; notably, several neurodevelopmental disorders, such as ASD and SCZ, manifest during this plasticity period [49, 50].”
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Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
The impact of environmental factors in severe psychiatric disorders
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Authors: Fatemi, S. H., & Folsom, T. D.
Affiliations: University of Minnesota (US)
ORCID: Fatemi, S. H.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2009-03-30
Volume: 35
Issue: 3
Pages: 528-548
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/schbul/sbn187
PMC: PMC2669580
OpenAlex: W2132748057
Cited by: 860
References: 222
Citations by year: 2026: 23 · 2025: 46 · 2024: 47 · 2023: 42 · 2022: 39 · 2021: 48 · 2020: 45 · 2019: 40 · 2018: 43 · 2017: 48 · 2016: 61 · 2015: 53 · 2014: 55 · 2013: 76 · 2012: 66
FWCI: 8.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Schizophrenia Bulletin (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046589)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, neurodevelopmental hypothesis
MeSH terms: Adolescent, Adult, Animals, Brain, Disease Models, Animal, Female, Humans, Infant, Newborn, Mutation, Nerve Net, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Schizophrenia, Schizophrenic Psychology, Virus Diseases, Gene Expression, Neurodegenerative Diseases, Oligonucleotide Array Sequence Analysis, Young Adult

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