The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
International Union of Pharmacology. XXIV. Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits
Abstract
ATP acts as a humoral mediator to control cell function extracellularly. The receptors that mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the transmitter-gated, ion channel P2X receptors. This review describes the structure, distribution, function, and ligand recognition characteristics of P2X receptors, which comprise seven distinct subunits that can function as both homo- and hetero- polymers. The pharmacology of P2X receptors is complicated by marked differences between species orthologues. The current nomenclature is based largely on recombinant receptor studies and detailed knowledge of endogenous P2X receptors in native tissues is limited because of lack of good selective agonists and antagonists for each receptor type.
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Cites
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Cited by
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Olsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064
Bours, M. J. L., Swennen, E. L. R., Di Virgilio, F., Cronstein, B. N., & Dagnelie, P. C. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.013 · Cited by 1,030
A nomenclature for ligand-gated ion channels
Collingridge, G. L., Olsen, R. W., Peters, J., & Spedding, M. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.063 · Cited by 600
Light, A. R., Hughen, R. W., Zhang, J., Rainier, J., Liu, Z., & Lee, J. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01344.2007 · Cited by 277
Metadata
- Authors
- Khakh, B. S., Burnstock, G., Kennedy, C., King, B. F., North, R. A., Séguéla, P., Voigt, M., & Humphrey, P. P. A.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 53
- Issue
- 1
- Pages
- 107-118
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W4406058880
- Cited by
- 667
- References
- 160
- FWCI
- 25.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Khakh, B. S., Burnstock, G., Kennedy, C., King, B. F., North, R. A., Séguéla, P., Voigt, M., & Humphrey, P. P. A. (2001). International Union of Pharmacology. XXIV. Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits. Pharmacological Reviews. https://doi.org/10.1016/s0031-6997(24)01482-0
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