Cited by 228Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

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Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology

Whitaker-Azmitia, P M·1991·Pharmacological Reviews

DOI 10.1016/s0031-6997(25)06668-2

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Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression
Wang, S., Zhang, Z., Guo, Y., Sui, Y., & Sun, Y. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.12.017 · Cited by 36
Disruption of Rat Forebrain Development by Glucocorticoids: Critical Perinatal Periods for Effects on Neural Cell Acquisition and on Cell Signaling Cascades Mediating Noradrenergic and Cholinergic Neurotransmitter/Neurotrophic Responses
Kreider, M. L., Aldridge, J. E., Cousins, M. M., Oliver, C. A., Seidler, F. J., & Slotkin, T. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300743 · Cited by 35
“Both of these transmitters play a critical role as trophic factors in development of the forebrain (Dreyfus, 1998; Hohmann, 2003; Hohmann and Berger-Sweeney, 1998; Lauder and Schambra, 1999; Whitaker-Azmitia, 1991) and are likely targets for developmental effects of glucocorticoids (Hu et al, 1996; Muneoka et al, 1997…”
Background
Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety
Gallinat, J., Ströhle, A., Lang, U. E., Bajbouj, M., Kalus, P., Montag, C., Seifert, F. C., Wernicke, C., Rommelspacher, H., Rinneberg, H. H., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.001 · Cited by 35
Development of an identified serotonergic neuron in the antennal lobe of the moth and effects of reduction in serotonin during construction of olfactory glomeruli
Oland, L. A., Kirschenbaum, S. R., Pott, W. M., et al. (1995) · Journal of Neurobiology · doi:10.1002/neu.480280210 · Cited by 35
Neonatal administration of citalopram delays somatic maturation in rats
Deiró, T. C. B. J., Manhães‐de‐Castro, R., Cabral-Filho, J. E., de Souza, S. L., Freitas-Silva, S. R., Ferreira, L. M. P., Guedes, R. C. A., Cámara, C. R., & Barros, K. M. F. T. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004001000009 · Cited by 34
“Experimental evidence indicates that serotonin can influence embryogenesis and growth (3,4) presumably by acting as a developmental signal (5) or as a neurotrophic factor as well (6).”
Background
Role of the neurotrophic properties of serotonin in the delay of brain maturation induced by cocaine.
Whitaker‐Azmitia, P. M. (1998) · PubMed · Cited by 34
Self-citation
Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice
Rutz, S., Riegert, C., Rothmaier, A. K., Buhot, M.-C., Cassel, J., & Jackisch, R. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.04.004 · Cited by 33
β-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization
Giannuzzi, C. E., Seidler, F. J., & Slotkin, T. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00781-k · Cited by 33
Regulation of fetal cardiac and hepatic β-adrenoceptors and adenylyl cyclase signaling: terbutaline effects
Auman, J. T., Seidler, F. J., & Slotkin, T. A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.4.r1079 · Cited by 33
“Equally important, the developing brain exhibits the same trophic role for b-adrenergic input in the control of cell replication and differentiation (1, 9, 14, 18, 21, 25, 40, 44) and thus is likely to provide a similar target for adverse effects of prenatal Ter treatment.”
Background
Neonatal ACTH Administration Elicits Long‐term Changes in Forebrain Monoamine Innervation
Alves, S. E., Akbari, H. M., Anderson, G. M., Azmitia, E. C., McEwen, B., & Strand, F. L. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46160.x · Cited by 32
Monocrotophos induced oxidative stress and alterations in brain dopamine and serotonin receptors in young rats
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Developmental Changes in the Electrophysiological Properties and Response Characteristics ofManducaAntennal-Lobe Neurons
Mercer, A. R., & Hildebrand, J. G. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.6.2650 · Cited by 30
“…and developmental events such as neurite outgrowth (Budnik et al. 1989; Goldberg and Kater 1989; Goldberg et al. 1990; Haydon et al. 1984, 1987; Whitaker-Azmitia 1991) and synaptogenesis (Chubakov et al. 1986; Goldberg and Kater 1989) have been shown also to be influenced by this modulatory…”
Background
Development and Adult Plasticity of Serotoninergic Neurons and Their Target Cells
Azmitia, E. C., & Whitaker‐Azmitia, P. M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60921-3_1 · Cited by 30
Self-citation
2,4-dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain
Brusco, A., Saavedra, J. P., Garcia, G. B., et al. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815096 · Cited by 30
Synaptic specificity: development of locomotor rhythmicity
Sillar, K. T. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90038-8 · Cited by 30
Prenatal Antidepressant Exposure and Child Motor Development: A Meta-analysis
Grove, K., Lewis, A. J., & Galbally, M. (2018) · PEDIATRICS · doi:10.1542/peds.2018-0356 · Cited by 29
Transient localization of 5-HT1A receptors in human cerebellum during development
del Olmo, E., Díaz, Á., Guirao-Piñeyro, M., et al. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90472-3 · Cited by 29
Mu opioid receptors in developing human spinal cord
Ray, S. B., & Wadhwa, S. (1999) · Journal of Anatomy · doi:10.1046/j.1469-7580.1999.19510011.x · Cited by 29
“The ontogeny of the different opioid receptors has been well characterised in lower mammals (Kornblum et al. 1987; Xia & Haddad, 1991) as well as in the rhesus monkey (Bachevalier et al. 1986).”
Developmental impairment of auditory evoked N1/P2 component in rats undernourished in utero: its relation to brain serotonin activity
Manjarrez‐Gutiérrez, G., Hernández, Z. E., Robles, O. A., González, R. M., & Hernández, R. J. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00129-8 · Cited by 27
Ontogeny of neurotransmitter systems: Substrates for developmental disabilities?
Lauder, J. M. (1995) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.1410010303 · Cited by 27
Role of the Neurotrophic Properties of Serotonin in the Delay of Brain Maturation Induced by Cocainea
WHITAKER‐AZMITIA, P. M. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09734.x · Cited by 26
Self-citation
Adolescent fluoxetine exposure produces enduring, sex-specific alterations of visual discrimination and attention in rats
LaRoche, R. B., & Morgan, R. E. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.11.008 · Cited by 26
Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
da Silva, V. A., Amorim, M. J. A. A. L., de Amorim, A. A., Pinto, C. F., Deiró, T. B. J., de Oliveira, J. R. M., Peixoto, C. A., & Manhães‐de‐Castro, R. (2008) · International Journal of Morphology · doi:10.4067/s0717-95022008000100009 · Cited by 27
“Experimental evidence indicates that serotonin (5-HT) can influence embryogenesis and growth presumably by acting as a developmental signal or as a neurotrophic factor as well (Liu & Lauder, 1992; Palén et al., 1979; Whitaker-Azmitia, 1991; Yan et al.,1997; Deiró et al., 2004).”
Background
Developmental exposure to a serotonin agonist produces subsequent behavioral and neurochemical changes in the adult male prairie vole
Martin, M. M., Liu, Y., & Wang, Z. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.015 · Cited by 26
Pre-hatching fluoxetine-induced neurochemical, neurodevelopmental, and immunological changes in newly hatched cuttlefish
Bidel, F., Poi, C. D., Imarazene, B., Kouéta, N., Budzinski, H., Delft, P. V., Bellanger, C., & Jozet‐Alves, C. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4591-7 · Cited by 28
“that the serotonergic systemmay have a significant function in the development of the nervous system, including the modulation of processes such as neuronal proliferation and synaptogenesis (Lauder 1990; Whitaker-Azmitia 1991; Benton et al. 1997; Banasr et al. 2004).”
Background
Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring
Cannizzaro, C., Plescia, F., Gagliano, M., Cannizzaro, G., Provenzano, G., Mantia, G., & Cannizzaro, E. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.05.012 · Cited by 24
Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors
Parga, J. A., Rodríguez‐Pallares, J., Muñoz, A., Guerra, M. J., & Labandeira-García, J. L. (2006) · Developmental Neurobiology · doi:10.1002/dneu.20306 · Cited by 24
The development of monoaminergic neurotransmitter systems in childhood and adolescence
Pitzer, M. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.02.002 · Cited by 25
“Independent of synaptic transmission, there is estimated to be a direct influence on growth and on the differentiation of neurons with regard to serotonin and dopamine, for example (Whitaker-Azmitia, 1991; Todd, 1995), whereby these processes occur during the fetal period for the most part.”
BackgroundInfluential
Serotonin uptake and release mechanisms in developing cultures of rat embryonic raphe neurons: age- and region-specific differences
Lautenschlager, M., Höltje, M., von Jagow, B., et al. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00222-0 · Cited by 23
Pleiotropic Effects of Neurotransmission during Development: Modulators of Modularity
Thompson, B. L., & Stanwood, G. D. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0624-0 · Cited by 22
“Developmentally, 5-HT signaling modulates cellular functioning even before the onset of neurogenesis, including events in the periphery such as craniofacial, gastrointestinal, and cardiovascular morphogenesis (Buz- nikov et al. 1996; Lauder 1983; Whitaker-Azmitia 1991; Whitaker-Azmitia et al. 1996).”
Very early treatment with fluoxetine and reboxetine causing long-lasting change of the serotonin but not the noradrenaline transporter in the frontal cortex of rats
Bock, N., Quentin, D. J., Huether, G., Moll, G. H., Banaschewski, T., & Rothenberger, A. (2005) · The World Journal of Biological Psychiatry · doi:10.1080/15622970510029731 · Cited by 23
Serotonergic receptors in the brain of in utero undernourished rats
Manjarrez‐Gutiérrez, G., Manuel-A, L., Mercado, R., & Hernández‐R, J. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00034-0 · Cited by 22
Cloning and developmental expression of 5-HT1A receptor gene in Xenopus laevis
Marracci, S., Cini, D., & Nardi, I. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00052-1 · Cited by 22
Prenatal morphine exposure differentially alters TH-immunoreactivity in the stress-sensitive brain circuitry of adult male and female rats
Vathy, I., He, H.-J., Iodice, M., et al. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00227-0 · Cited by 22
Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
Deiró, T. C. B. D. J., Carvalho, J. L., do Nascimento, E., Medeiros, J. M. B., Cajuhi, F., Ferraz‐Pereira, K. N., & Manhães‐de‐Castro, R. (2008) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2008000500025 · Cited by 20
Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase
Slotkin, T. A., Lorber, B. A., McCook, E. C., et al. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00067-n · Cited by 21
Terbutaline impairs the development of peripheral noradrenergic projections: Potential implications for autism spectrum disorders and pharmacotherapy of preterm labor
Slotkin, T. A., & Seidler, F. J. (2012) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.003 · Cited by 22
“…such as norepinephrine, serotonin and acetylcholine, act as morphogens to direct the assembly of the mammalian brain (BruelJungerman et al., 2011; Lauder, 1985; Whitaker-Azmitia, 1991), a function that likely evolved from their roles in invertebrate embryogenesis (Buznikov et al., 1996, 2007).”
Effet de l’exposition chronique au nickel sur les fonctions neurocomportementales chez les rats Wistar pendant la période de développement
Kahloula, K., Adli, D. E. H., Slimani, M., et al. (2014) · Annales de Toxicologie Analytique · doi:10.1016/j.toxac.2014.09.056 · Cited by 20
Early mood behavioral changes following exposure to monotonous environment during isolation stress is associated with altered hippocampal synaptic plasticity in male rats
Das, S. K., Baitharu, I., Barhwal, K. K., Hota, S. K., & Singh, S. B. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.038 · Cited by 21
Development of the human cerebral cortex: A histochemical study
Tiu, S. C., Yew, D. T. W., & Chan, W. Y. (2002) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(02)80002-x · Cited by 20
Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder
Wegiel, J., Chadman, K. K., London, E., Wısnıewskı, T., & Węgiel, J. (2024) · Autism Research · doi:10.1002/aur.3123 · Cited by 19
Elements toward novel therapeutic targeting of the adrenergic system
Ghanemi, A., & Hu, X. (2014) · Neuropeptides · doi:10.1016/j.npep.2014.11.003 · Cited by 19
“More importantly, NA directs a2-AR development (Landis, 1990; Lauder, 1993; Lipton and Kater, 1989; Whitaker-Azmitia, 1991) which confirms adrenergic receptors’ (ARs) involvement in brain development (Blue and Parnavelas, 1982; Rowe et al., 1993; Soto-Moyano et al., 1994).”
Influential
Effects of prenatal and postnatal exposure to amitraz on norepinephrine, serotonin and dopamine levels in brain regions of male and female rats
del Pino, J., Martínez, M., Castellano, V., Ramos, E., Martínez-Larrañaga, M. R., & Anadón, A. (2011) · Toxicology · doi:10.1016/j.tox.2011.06.009 · Cited by 19
Effects of neonatal clomipramine on cholinergic receptor sensitivity and passive avoidance behavior in adult rats
Prathiba, J., Kumar, K. B., & Karanth, K. S. (1995) · Journal of Neural Transmission · doi:10.1007/bf01271532 · Cited by 19
Ontogeny of endothelin and its receptors in rat brain
Gulati, A., Rebello, S. S., Chari, G., et al. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90300-e · Cited by 19
Atypical Regulation of Hepatic Adenylyl Cyclase and Adrenergic Receptors During a Critical Developmental Period: Agonists Evoke Supersensitivity Accompanied by Failure of Receptor Down-Regulation
Thai, L., Galluzzo, J. M., McCook, E. C., Seidler, F. J., & Slotkin, T. A. (1996) · Pediatric Research · doi:10.1203/00006450-199604000-00023 · Cited by 19
Noradrenergic and Serotonergic Neuroendocrine Responses in Prepubertal, Peripubertal, and Postpubertal Rats Pretreated With Desipramine and Sertraline
CARREY, N. J., Dursun, S. M., CLEMENTS, R., Renton, K. W., Waschbusch, D. A., & MacMaster, F. P. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200208000-00019 · Cited by 19
“This is consistent with serotonin’s dual role in development as a neurotransmitter and trophic factor (Whitaker-Azmitia, 1991).”
Background
Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants
Deng, D. R., Djalali, S., Höltje, M., Groβe, G., Stroh, T., Voigt, I., Kusserow, H., Theuring, F., Ahnert‐Hilger, G., & Hörtnagl, H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.004 · Cited by 20
The Role of Serotonin and Serotonin Receptors in Development of the Mammalian Nervous System
Whitaker‐Azmitia, P. M. (1993) · Springer eBooks · doi:10.1007/978-94-011-1544-5_3 · Cited by 18
Self-citation
Early Malnourished Rats are not Affected by Anorexia Induced by a Selective Serotonin Reuptake Inhibitor in Adult Life
Medeiros, J. M. B., Filho, J. E. C., de Souza, S. L., Silva, S. R. F., Silva, C. M. D., Deiró, T. C. B. J., Monteiro, J. M., Guedes, R. C. A., de Castro, C. M. M. B., & de Castro, R. M. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290029197 · Cited by 18
“This density and location might be improved by the increased brain serotonin deriving from malnutrition, because of the role of this amine on serotoninergic ontogenesis itself (Whitaker-Azmitia, 1991; Liu and Lauder, 1992).”
Background
Neonatal noradrenaline depletion prevents the transition of Bergmann glia in the developing cerebellum
Podkletnova, I., & Alho, H. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00006-4 · Cited by 18
The effects of cocaine on cerebral metabolic function in periweanling rats: the roles of serotonergic and dopaminergic uptake blockade
Frick, G. S., & Dow-Edwards, D. L. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00094-t · Cited by 17
Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: Sex-selective effects on cerebrocortical serotonergic function
Slotkin, T. A., Card, J., & Seidler, F. J. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.01.004 · Cited by 18
“Neural plasticity in the immature brain is highly influenced by patterns of synaptic activity because neurotransmitters act as morphogens, controlling neuronal cell replication, differentiation and circuit formation (Dreyfus, 1998; Lauder, 1985; Whitaker-Azmitia, 1991).”
Background
Maternal fluoxetine treatment decreases behavioral response to dopaminergic drugs in female pups
Favaro, P. D. N., Costa, L. C., & Moreira, E. G. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.05.002 · Cited by 17
Neonatal stimulation of 5‐HT2receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic area
Dakin, C. L., Wilson, C. A., Kalló, I., Coen, C. W., & Davies, D. C. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06216.x · Cited by 17
“5-HT is an important regulator of neuronal growth and differentiation, exerting an autoregulatory effect on 5-HT neurons and inducing maturation of target areas of 5-HT efferents (Lauder et al., 1981, 1985; Liu & Lauder, 1991; Whitaker-Azmitia, 1991; Whitaker-Azmitia et al., 1996).”
Background
Mild iron deficiency anaemia during pregnancy and lactation in guinea pigs alters amplitudes and auditory nerve velocity, but not brainstem transmission times in the offspring's auditory brainstem response
Jougleux, J., Rioux, F. M., Church, M. W., Fiset, S., & Surette, M. E. (2013) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000067 · Cited by 17
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents
Bell, J. A., Zhang, X., & Whitaker‐Azmitia, P. M. (1992) · Brain Research · doi:10.1016/0006-8993(92)90667-x · Cited by 17
Self-citation
Ontogeny of β-adrenoceptor/adenylyl cyclase desensitization mechanisms: the role of neonatal innervation
Slotkin, T. A., Saleh, J. L., Zhang, J., et al. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00978-x · Cited by 17
The Influence of Gender and Age on Neonatal Rat Hypothalamic 5-HT1A and 5-HT2A Receptors
Ferrari, P.-F., Lowther, S., Tidbury, H., Greengrass, P. M., Wilson, C. A., & Horton, R. W. (1999) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006909207742 · Cited by 17
“Over the developmental period, 5-HT has an important trophic effect on neuronal growth of its own system as well as others (Whitaker-Azmitia, 1991).”
Background
Maternal treatment with fluoxetine promotes testicular alteration in male rat pups
Ramos, A. C., dos Santos, A. H., Silveira, K. M., Kiss, A. C. I., Mesquita, S. D. F. P., & Gerardin, D. C. C. (2015) · Reproduction Fertility and Development · doi:10.1071/rd14199 · Cited by 16
“Serotonin (5-hydroxytryptamine; 5-HT) influences embryogenesis and growth, probably by acting as a developmental signal or as a neurotrophic factor (Palén et al. 1979; Whitaker-Azmitia 1991; Liu and Lauder 1992; Yan et al. 1997; Deiró et al. 2004).”
Background
Polychlorinated biphenyls (PCBs) selectively disrupt serotonergic cell growth in the developing Spisula embryo
Smith, C. R., Barker, C. M., Barker, L. F., et al. (1999) · Toxicological Sciences · doi:10.1093/toxsci/50.1.54 · Cited by 16
“Serotonin, a highly conserved neurotransmitter, is critically important because of its pivotal role in regulating neuronal growth, differentiation, and plasticity during embryogenesis in vertebrate and invertebrate animals (Benton, 1994; Lauder, 1982; Whitaker-Azmitia, 1991).”
Background
The potential role of substance P in brainstem homeostatic control in the pathogenesis of sudden infant death syndrome (SIDS)
Bright, F., Vink, R., & Byard, R. W. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.02.006 · Cited by 15
“Moreover, the development of different neurotransmitter systems may be directly related to one another (125).”
Immunohistochemical localization of substance P receptors in the midline glia of the developing rat medulla oblongata with special reference to the formation of raphe nuclei
Horie, M., Miyashita, T., Watabe, K., et al. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00048-1 · Cited by 15
Notch1 signaling related hippocampal neurogenesis in adult poststroke depression rats: a valid index for an efficient combined citalopram and WAY100635 pharmacotherapy
Wang, S., Zhang, Z., Guo, Y., Sui, Y., & Sun, Y. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328334b677 · Cited by 15
“5-HT has been shown to exert a neurogenic effect in the CNS during development (Whitaker-Azmitia, 1991).”
Background
Developmental Neurobiology: Implications for Pediatric Psychopharmacology
CARREY, N. J. (2001) · The Canadian Journal of Psychiatry · doi:10.1177/070674370104600904 · Cited by 15
Pre- and post-hatching developmental changes in β-adrenoceptor subtypes in chick brain
Revilla, R., Fernández-López, C., Revilla, V., & Fernández‐López, A. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00133-3 · Cited by 14
Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development
Sanders, J. D., Happe, H. K., Bylund, D., & Murrin, L. C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.045 · Cited by 14
“Many studies have shown that neurotransmitters, including NE, play important roles as regulators of nervous system development (Landis, 1990; Lauder, 1993; see Lipton and Kater, 1989; Meier et al., 1991; Whitaker-Azmitia, 1991).”
Background
Nonenzymatic role of acetylcholinesterase in neuritic sprouting: Regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions
Slotkin, T. A., Ryde, I. T., Wrench, N., Card, J., & Seidler, F. J. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.12.007 · Cited by 12
“During brain development, neurotransmitters serve important trophic functions that control neuronal cell replication and differentiation, synaptic organization, and morphologic assembly of brain nuclei [19,54,55].”
Background
Effects of the altered serotonergic signalling by neonatal treatment with 5,7-dihydroxytryptamine, ritanserin or clomipramine on the adrenocortical stress response and the glucocorticoid receptor binding in the hippocampus in adult rats
Ogawa, T., Mikuni, M., Kuroda, Y., Muneoka, K. T., Mori, K. J., & Takahashi, K. (1994) · Journal of Neural Transmission · doi:10.1007/bf01277933 · Cited by 13
“On the other hand, recent progress in developmental pharmacology clearly reveals that pharmacological manipulations of receptors in an immature brain can result in permanent changes once that brain is mature (Whitaker-Azmitia, 1991).”
Background
Neuronal Control of Cardiac and Hepatic Macromolecule Synthesis in the Neonatal Rat: Effects of Sympathectomy
Renick, S. E., Seidler, F. J., McCook, E. C., et al. (1997) · Pediatric Research · doi:10.1203/00006450-199703000-00009 · Cited by 13
Normative distribution of substance P and its tachykinin neurokinin-1 receptor in the medullary serotonergic network of the human infant during postnatal development
Bright, F., Byard, R. W., Vink, R., & Paterson, D. S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.009 · Cited by 12
Ritanserin blocks DOI-altered embryonic motility and posthatch learning in the developing chicken
Bollweg, G. L., & Sparber, S. B. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00109-8 · Cited by 12
A transient expression of functional α2-adrenergic receptors in white matter of the developing brain
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Aminergic receptors during the development of the human brain: the contribution of in vitro imaging techniques
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“In general terms, transiently and early expressed receptors can play a role themselves in brain development, sometimes by producing high levels of second messengers (see Whitaker-Azmitia, 1991).”
BackgroundInfluential
Reorganization of the corticotectal projections introduced by neonatal monocular enucleation in the Monodelphis opossum and the influence of serotoninergic depletion
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Ethanol exposure alters the development of serotonergic neurons in chick spinal cord
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Further Characterization of 5-HT1A Receptors in the Goldfish Retina: Role of Cyclic AMP in the Regulation of the In Vitro Outgrowth of Retinal Explants
Schmeer, C. W., Obregón, F., Urbina, M., & Lima, L. (2001) · Neurochemical Research · doi:10.1023/a:1010960332229 · Cited by 9
“receptors enhance secretion of the S100 protein, which has been shown to promote the growth of serotoninergic neurons (23,24).”
Background
Tyrosine Hydroxylase Expression in Differentiating Neurons of theRat Arcuate Nucleus: Stimulatory Influence of Serotonin Afferents
Melnikova, V. I., Ugrumov, M. V., Proshlyakova, E. V., et al. (2001) · Neural Plasticity · doi:10.1155/np.2001.271 · Cited by 9
“The data presented here are consistent with prior observations that the differentiation of serotonin neurons is influenced by their targets (Azmitia et al., 1990; Whitaker-Azmitia, 1991).”
Result
Developmental pharmacodynamics: implications for child and adolescent psychopharmacology.
CARREY, N. J., & Kutcher, S. (1998) · PubMed · Cited by 9
Restriction of Maternal Dietary Carbohydrate Decreases Fetal Brain Indoles and Glycogen in Rats
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Prenatal Stress Modulates Placental and Fetal Serotonin Levels and Determines Behavior Patterns in Offspring of Mice
Melnikova, V. I., Лифанцева, Н. В., Voronova, S. N., & Bondarenko, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413565 · Cited by 9
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Haynes, R. L., Kinney, H. C., Haas, E. A., Duncan, J. R., Riehs, M. A., Trachtenberg, F. L., Armstrong, D. D., Alexandrescu, S., Cryan, J. B., Hefti, M. M., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.762017 · Cited by 8
Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine
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Ontogenetic Development of 5‐HT1D Receptors in Human Brain: An Autoradiographic Study
del Olmo, E., del Arco, C., Díaz, Á., Pascual, J., Mengod, G., Palacios, J. M., & Pazos, Á. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01166.x · Cited by 8
Microglial response to the neurotoxicity of 6‐hydroxydopamine in neonatal rat cerebellum
Podkletnova, I., Rothstein, J. D., Helén, P. T., et al. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00069-1 · Cited by 8
“…as a neurotrophic factor in the period of cell differentiation, i.e. during the first 2 postnatal weeks for the rat cerebellum (Rowe et al., 1993; Whitaker-Azmitia, 1991), and plays an important role in the postnatal maturation of Purkinje cells and granule neurons (Attwell et al., 1993; Felten…”
Background
Developmental expression of tryptophan hydroxylase mRNAs in the rat pineal gland: an in situ hybridization study
Besançon, R., Chouaf, L., Jouvet, A., et al. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00256-e · Cited by 8
Acute Regulation and Long-Term Modulation of Presynaptic Serotonin Output
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Serotonergic development of active sensingPreprint
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“…signaling during early postnatal development impairs the structure and function of neural circuits throughout the brain (Shemer et al., 1991; Whitaker-Azmitia, 1991; Moses-Kolko et al., 2005; Deiró et al., 2006; Pang et al., 2011; Kiryanova et al., 2013; Kroeze et al., 2016), results in…”
Background
Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment
Culvenor, J. G., Maher, F., Evin, G. M., Malchiodi‐Albedi, F., Cappai, R., Underwood, J. R., Davis, J. B., Karran, E. H., Roberts, G. W., Beyreuther, K. T., et al. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 76
Perspectives on gender differences in food intake and frequency of disease
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Neonatal 6-Hydroxydopamine Treatment Affects GABAA Receptor Subunit Expression in the Frontal Cortex but Not the Hippocampus of Rats during Postnatal Development
Podkletnova, I., Mäkelä, R., Korpi, E. R., Lüddens, H., Helén, P., & Alho, H. (2000) · Developmental Neuroscience · doi:10.1159/000017453 · Cited by 6
Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats
Gutierrez, V. A., Carrillo, A. A., Boersma, G. J., Tamashiro, K. L., Moran, T. H., Iñiguez, S. D., & Treesukosol, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136818 · Cited by 9
“Mainly, because under normal conditions, serotonin has tropic effects, and alterations of this system can induce changes to synaptic sprouting and formation [66,110], and also could potentially alter cortical organization [52].”
Background
Dietary LC-PUFA in iron-deficient anaemic pregnant and lactating guinea pigs induce minor defects in the offsprings' auditory brainstem responses
Jougleux, J., Rioux, F. M., Church, M. W., Fiset, S., Jacques, H., & Surette, M. E. (2014) · Nutritional Neuroscience · doi:10.1179/1476830514y.0000000140 · Cited by 6
Phytochemicals as Antidepressants: The Involvement of Serotonin Receptor Function, Stress Resistance and Neurogenesis
Wang, R., & Xu, Y. D. (2012) · InTech eBooks · doi:10.5772/27531 · Cited by 5
“5-HT, as an important neurotransmitter, has long been reported to exert an important mitogenic action in the central neural system (CNS) during development (Lauder et al., 1981; Whitaker-Azmitia,1991).”
Background
Effects of selective serotonin reuptake inhibitors on the placenta
Ellenberger, D. T., Herrington, R. T. B., Seda, S. E., Lambert, A. N., & Rosenfeld, C. S. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf141 · Cited by 4
Neonatal 6‐hydroxydopamine treatment affects GABAA receptor subunit expression during postnatal development of the rat cerebellum
Podkletnova, I., Alho, H., Mäkelä, R., et al. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00003-4 · Cited by 4
“However, other transmitter systems (such as serotoninergic and glutamatergic systems) may compensate for the lack of the lesioned noradrenergic terminals [17,34,35].”
Background

Authors: Whitaker-Azmitia, P. M.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 1991-12
Volume: 43
Issue: 4
Pages: 553-561
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1016/s0031-6997(25)06668-2
OpenAlex: W2230711217
Cited by: 226
References: 0
Citations by year: 2025: 1 · 2024: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 3
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: serotonin, neurotransmitter receptors, brain development, developmental pharmacology
MeSH terms: Animals, Brain, Humans, Receptors, Serotonin, Developmental Biology, Receptors, Neurotransmitter

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Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology

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