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Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology
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Trajectories of brain development: point of vulnerability or window of opportunity?
Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503
“The action of some of these factors will be discussed as they influence trajectories of brain development via direct or indirect actions on the development of their own systems [227].”
BackgroundEstrogen Actions in the Central Nervous System
McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,504
“Serotonin neurons of the midbrain/brainstem raphe nuclei are among the earliest neuronal phenotype to become differentiated during CNS development, and serotonin is believed to act as a regulatory/developmental agent (176, 177).”
BackgroundAdult brain neurogenesis and psychiatry: a novel theory of depression
Jacobs, B. L., van Praag, H., & Gage, F. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000712 · Cited by 964
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 831
Neurotransmitters as growth regulatory signals: role of receptors and second messengers
Lauder, J. M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90162-f · Cited by 806
Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice
Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704
Fetal Nicotine or Cocaine Exposure: Which One is Worse?
Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37495-6 · Cited by 676
“The phenotypic expression of the ability to manufacture neurotransmitters or their receptors is a common feature of developing cells and even occurs in nonneuronal cells, in which it is now clear that transmitter chemicals play roles outside the realm of classical synaptic communication (Lauder, 1985; Whitaker-Azmitia…”
BackgroundBrezun, J. M., & Daszuta, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00693-9 · Cited by 549
Slotkin, T. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.06.001 · Cited by 544
“Keywords: Tobacco smoke; Neurotoxicity; Neurotransmitters Beginning in the 1960s, Buznikov et al. (1964, 1970) system (Lauder, 1985; Whitaker-Azmitia, 1991).”
Serotonin and brain development: role in human developmental diseases
Whitaker-Azmitia, P. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00615-3 · Cited by 506
Self-citationImpaired spatial and sequential learning in rats treated neonatally with d ‐fenfluramine
Morford, L. L., Inman-Wood, S. L., Gudelsky, G. A., Williams, M. T., & Vorhees, C. V. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02100.x · Cited by 454
“The neurotrophic effects of 5-HT play a role in embryogenesis (Lauder, 1988) and neuronal differentiation (Whitaker-Azmitia, 1991; Broening & Slikker, 1998; Frost & Cadet, 2000).”
BackgroundHypothalamic dopamine and serotonin in the regulation of food intake
Meguid, M. M., Fetissov, S. O., Varma, M., Sato, T., Zhang, L., Laviano, A., & Fanelli, F. R. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00449-4 · Cited by 423
Schmidt, B. J., & Jordan, L. M. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00402-0 · Cited by 425
Potential developmental neurotoxicity of pesticides used in Europe
Bjørling-Poulsen, M., Andersen, H. R., & Grandjean, P. (2008) · Environmental Health · doi:10.1186/1476-069x-7-50 · Cited by 407
Serotonin as a developmental signal
Whitaker-Azmitia, P. M., Druse, M., Walker, P., & Lauder, J. M. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00071-x · Cited by 356
Self-citationNeonatal Antidepressant Exposure has Lasting Effects on Behavior and Serotonin Circuitry
Maciąg, D., Simpson, K. L., Coppinger, D., Lu, Y., Wang, Y., Lin, R. C. S., & Paul, I. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300823 · Cited by 309
“Thus, the developing CNS during the prenatal and early postnatal periods is uniquely vulnerable to neurobiological teratogenicity due to exogenous drug exposure (Lauder, 1990; Whitaker-Azmitia, 1991).”
BackgroundMazer, C., Muneyyirci, J., Taheny, K., Raio, N., Borella, A., & Whitaker‐Azmitia, P. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00297-7 · Cited by 287
Self-citationDevelopmental cholinotoxicants: nicotine and chlorpyrifos
Slotkin, T. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s171 · Cited by 292
The recombinant 5‐HT 1A receptor: G protein coupling and signalling pathways
Raymond, J. R., Mukhin, Y. V., Gettys, T. W., & Garnovskaya, M. N. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702723 · Cited by 239
“Furthermore, in glial cells, endogenous 5-HT1A receptors stimulate secretion of the S100 protein, which has been shown to promote the growth of serotoninergic neurons (Lauder, 1993; Whitaker-Azmitia, 1991).”
BackgroundDopamine and noradrenaline control distinct functions in rodent microglial cells
Färber, K., Pannasch, U., & Kettenmann, H. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.01.003 · Cited by 247
5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
Radley, J. J., & Jacobs, B. L. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03477-7 · Cited by 231
Direct and indirect cellular effects of aspartame on the brain
Humphries, P., Pretorius, E., & Naudé, H. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602866 · Cited by 229
Maturation of the Mammalian Respiratory System
Hilaire, G., & Duron, B. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.325 · Cited by 215
Slotkin, T. A. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.002 · Cited by 206
From oocyte to neuron: Do neurotransmitters function in the same way throughout development?
Buznikov, G. A., Shmukler, Y. B., & Lauder, J. M. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02152056 · Cited by 195
Ogawa, T., Mikuni, M., Kuroda, Y., Muneoka, K. T., Mori, K. J., & Takahashi, K. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90250-x · Cited by 185
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181
Whitaker‐Azmitia, P. M., Clarke, C., & Azmitia, E. C. (1993) · Synapse · doi:10.1002/syn.890140303 · Cited by 181
Self-citationHansson, S. R., Mezey, É., & Hoffman, B. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00444-2 · Cited by 170
Norrholm, S. D., & Ouimet, C. C. (2001) · Synapse · doi:10.1002/syn.10006 · Cited by 169
Aldridge, J. E., Seidler, F. J., & Slotkin, T. A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6713 · Cited by 163
Murrin, L. C., Sanders, J. D., & Bylund, D. B. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.028 · Cited by 152
“As a general rule, serotonergic receptors in both humans and rats attain peak levels in fetal or early neonatal life and then decrease to adult levels [69].”
BackgroundNicotine Evokes Cell Death in Embryonic Rat Brain during Neurulation
Roy, T. S., Andrews, J. E., Seidler, F. J., & Slotkin, T. A. (1998) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37911-x · Cited by 147
“…acting as trophic substances, typically elicit biphasic developmental actions, promoting cell division at early stages but fostering the switch from replication to differentiation later in development (Buznikov et al., 1970; Lauder, 1985; Slotkin et al., 1987c, 1988a,b; Whitaker-Azmitia, 1991).”
Adult brain neurogenesis and depression
Jacobs, B. L. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00015-6 · Cited by 147
Evolutionary ancient roles of serotonin: long-lasting regulation of activity and development
Turlejski, K. (1996) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1996-1167 · Cited by 146
Andersen, S. L., & Navalta, C. P. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.06.002 · Cited by 141
“In cell culture, elevated levels of serotonin decrease neuronal branching (Whitaker-Azmitia and Azmitia, 1986; Whitaker-Azmitia, 1991), which contrasts findings obtained from adult exposure studies showing antidepressantenhanced neurogenesis (Gould, 1999; Malberg et al.”
BackgroundBroening, H. W., Morford, L. L., Inman-Wood, S. L., Fukumura, M., & Vorhees, C. V. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03228.2001 · Cited by 143
“MDMA may affect the developing brain differently, because 5-HT has neurotrophic effects before the maturation of its neurotransmitter function (Lauder and Krebs, 1978; Lauder et al., 1983; Lauder, 1988; Whitaker-Azmitia, 1991).”
BackgroundAldridge, J. E., Seidler, F. J., Meyer, A., Thillai, I., & Slotkin, T. A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6489 · Cited by 143
The 5-HT1A receptor: Signaling, desensitization, and gene transcription
Albert, P. R., Lembo, P. M. C., STORRING, J., Charest, A., & Saucier, C. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)80055-8 · Cited by 131
Bou, C., Lajard, A.-M., Monteau, R., Maeyer, E. D., Seif, I., Lanoir, J., & Hilaire, G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04646.2000 · Cited by 127
“…that is expressed from an early embryonic age and is involved in several nervous maturational processes and functions (Lauder and Krebs, 1978; Vogt, 1982; Lauder et al., 1985; Whitaker-Azmitia, 1991; Hamon and Gozlan, 1993; Lauder, 1993; Hoyer et al., 1994; Peroutka, 1994; Levitt et al., 1997).”
BackgroundRen‐Patterson, R. F., Cochran, L. W., Holmes, A., Sherrill, S., Huang, S., Tolliver, T. J., Lesch, K., Lu, B., & Murphy, D. L. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20410 · Cited by 130
“…behaviors; nociception Serotonin (5-HT) is an important morphogenetic contributor to brain development before synapses are formed, in addition to its subsequent role as a neurotransmitter (Lauder, 1990; Whitaker-Azmitia, 1991; Turlejski, 1996; Whitaker-Azmitia, 2001; Gaspar et al., 2003).”
BackgroundInhibitory Effect of Hippocampal 5-HT1A Receptors on Human Explicit Memory
Yasuno, F., Suhara, T., Nakayama, T., Ichimiya, T., Okubo, Y., Takano, A., Ando, T., Inoue, M., Maeda, J., & Suzuki, K. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.334 · Cited by 123
Booij, L., Tremblay, R. E., Szyf, M., & Benkelfat, C. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140099 · Cited by 127
Psychobiology of childhood maltreatment: effects of allostatic load?
Grassi-Oliveira, R., Ashy, M., & Stein, L. M. (2008) · Revista Brasileira de Psiquiatria · doi:10.1590/s1516-44462008000100012 · Cited by 116
Vinay, L., Brocard, F., Clarac, F., Norreel, J.-C., Pearlstein, É., & Pflieger, J. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00195-9 · Cited by 118
Slotkin, T. A., Tate, C. A., Ryde, I. T., Levin, E. D., & Seidler, F. J. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9337 · Cited by 116
Castro, E., Díaz, Á., del Olmo, E., & Pazos, Á. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00340-4 · Cited by 115
Whitaker‐Azmitia, P. M., Zhang, X., & Clarke, C. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.42 · Cited by 109
“In addition, adult behaviors can be dependent upon chemical imprinting during develop ment; the level of a neurotransmitter has to be at the appropriate level at a certain developmental stage for subsequent behaviors to develop properly, meaning that the neurochemical and behavioral change do not need to coexist (Whi…”
BackgroundSelf-citationSerotonin and neurogenesis in the hippocampal dentate gyrus of adult mammals
Djavadian, R. L. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1505 · Cited by 109
Slotkin, T. A., Seidler, F. J., Qiao, D., Aldridge, J. E., Tate, C. A., Cousins, M. M., Proskocil, B. J., Sekhon, H. S., Clark, J. A., Lupo, S. L., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300544 · Cited by 101
“…of cell replication and differentiation, synaptic outgrowth, and apoptosis (Shaywitz and Greenberg, 1999; Stachowiak et al, 2003) and is a common site for disruption of brain development by neuroteratogens (Levitt et al, 1997; Slotkin et al, 2003a; Whitaker-Azmitia, 1991; Yanai et al, 2002).”
BackgroundAlpha-2 adrenergic receptor development in rat CNS: an autoradiographic study
Happe, H. K., Coulter, C. L., Gerety, M. E., Sanders, J. D., O’ROURKE, M. E., Bylund, D., & Murrin, L. C. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.004 · Cited by 100
The Main Features of Central 5-HT1A Receptors
Hamon, M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60921-3_9 · Cited by 95
Perireceptor events in olfaction
Pelosi, P. (1996) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199605)30:1 · Cited by 251
Barr, A. M., Fiorino, D. F., & Phillips, A. G. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00156-2 · Cited by 91
Developmental Neurotoxicity of Organophosphates
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[18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain
Aznavour, N., & Zimmer, L. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.09.023 · Cited by 87
Talley, E. M., Sadr, N. N., & Bayliss, D. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04473.1997 · Cited by 87
“…below), high levels of expression of 5-HT1A receptor in areas of the neonate brain that are devoid of receptor in the adult and at times preceding substantial serotonergic innervation intimate that the receptors might be involved in neural development (Whitaker-Azmitia, 1991; Lauder, 1993).”
BackgroundYohn, N. L., & Blendy, J. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.11 · Cited by 87
Risks of using SSRI / SNRI antidepressants during pregnancy and lactation
Dubovický, M., Belovičová, K., Csatlósová, K., & Bögi, E. (2017) · Interdisciplinary Toxicology · doi:10.1515/intox-2017-0004 · Cited by 93
Slotkin, T. A., Ryde, I. T., Levin, E. D., & Seidler, F. J. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.10.008 · Cited by 83
Slotkin, T. A., & Seidler, F. J. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.08.020 · Cited by 83
“The reason this is important is that 5HT plays a critical morphogenetic role in the developing brain (Lauder, 1985; Whitaker-Azmitia, 1991; Dreyfus, 1998).”
Cameron, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.012 · Cited by 88
Friauf, E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903340105 · Cited by 82
Norrholm, S. D., & Ouimet, C. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02909-7 · Cited by 82
Hirst, W. D., Price, G. W., Rattray, M., & Wilkin, G. P. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700921 · Cited by 81
“At the present time physiological roles for astrocytic 5- HT7 receptors remain speculative although these cells have been suggested to play a role in the development of the 5- hydroxytryptaminergic system within the central nervous system (Whitaker-Azmitia, 1991).”
BackgroundThe Psychopharmacology of Obsessive Compulsive Disorder: Implications for Treatment and Pathogenesis
McDougle, C. J., Goodman, W. K., Leckman, J. F., & Price, L. H. (1993) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30148-5 · Cited by 80
Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism
Kahne, D. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00673-4 · Cited by 78
Nichols, C. D. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20370 · Cited by 77
“The sero- tonin receptor subtype that has been the most closely linked to both neuropsychiatric disorders such as schizophrenia (Vollenweider et al., 1998), and working memory (Williams et al., 2002), is the 5-HT2A receptor.”
BackgroundRelationship of neuroendocrine cells of prostate and serotonin to benign prostatic hyperplasia
Cockett, A. T. �., di Sant'Agnese, P. A., Gopinath, P., et al. (1993) · Urology · doi:10.1016/0090-4295(93)90260-h · Cited by 75
Development and Characterization of Monoclonal Antibodies Specific to the Serotonin 5-HT 2A Receptor
Wu, C., Yoder, E. J., Shih, J. C., Chen, K., Dias, P., Shi, L., Ji, X.-D., Wei, J., Conner, J. M., Kumar, S., et al. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600704 · Cited by 69
Neonatal S100B Protein Levels After Prenatal Exposure to Selective Serotonin Reuptake Inhibitors
Pawluski, J. L., Galea, L. A. M., Brain, U., Papsdorf, M., & Oberlander, T. F. (2009) · Pediatrics · doi:10.1542/peds.2009-0442 · Cited by 65
Understanding Developmental Pharmacodynamics
Mulla, H. (2010) · Pediatric Drugs · doi:10.2165/11319220-000000000-00000 · Cited by 65
Whitaker‐Azmitia, P. M. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00081-a · Cited by 63
Self-citationSillar, K. T., Woolston, A.-M., & Wedderburn, J. F. S. (1995) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1995.0010 · Cited by 62
Raines, K., Seidler, F. J., & Slotkin, T. A. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00211-5 · Cited by 59
Cell Signaling as a Target and Underlying Mechanism for Neurobehavioral Teratogenesis
Yanai, J., Vatury, O. M., & Slotkin, T. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04188.x · Cited by 59
Serotonin-2 receptors in the CNS of alcohol-preferring and -nonpreferring rats
McBride, W. J., Chernet, E., Rabold, J. A., Lumeng, L., & Li, T. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90554-7 · Cited by 55
Lao, C. L., Lu, C., & Chen, J. (2013) · Glia · doi:10.1002/glia.22449 · Cited by 57
“For instance, the neurotransmitters dopamine (DA), serotonin (5-HT) and gamma-aminobutyric acid (GABA) are all known to affect NSC/NPC proliferation during early brain development and in the adult brain (Vicini, 2008; Whitaker-Azmitia, 1991).”
BackgroundAL‐SHAMMA, H. A., & Vries, G. J. D. (1996) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199601)29:1 · Cited by 45
Astrocytic β2-adrenergic receptors: From physiology to pathology
Laureys, G., Clinckers, R., Gerlo, S., Spooren, A., Wilczak, N., Kooijman, R., Smolders, I. J., Michotte, Y. M., & Keyser, J. D. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.011 · Cited by 57
Riad, M., Emerit, M. B., & Hamon, M. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90167-8 · Cited by 55
de Castro, R. M., Medeiros, J. M. B., da Silva, C. M., Ferreira, L. M. P., Guedes, R. C. A., Filho, J. E. C., & Costa, J. A. D. I. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000100015 · Cited by 53
“Furthermore, experimental evidence indicates that serotonin can influence embryogenesis and growth (7,8) presumably by acting as a developmental signal (9) or a neurotrophic factor (10).”
BackgroundLocomotor Network Maturation Is Transiently Delayed in the MAOA-Deficient Mouse
Cazalets, J., Gardette, M., & Hilaire, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.2468 · Cited by 53
Clarke, C., Clarke, K., Muneyyirci, J., Azmitia, E. C., & Whitaker‐Azmitia, P. M. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(95)00192-1 · Cited by 51
Self-citationPerinatal Development of the Motor Systems Involved in Postural Control
Vinay, L., Ben‐Mabrouk, F., Brocard, F., Clarac, F., Jean-Xavier, C., Pearlstein, É., & Pflieger, J. (2005) · Neural Plasticity · doi:10.1155/np.2005.131 · Cited by 50
“The monoaminergic pathways, which are among the earliest axonal systems to invade the developing spinal cord (Commissiong, 1983; Kudo et al., 1993; Lakke, 1997), can play such a role (Whitaker-Azmitia, 1991, 1996; Gaspar et al., 2003 ).”
BackgroundDevelopmental Cholinotoxicants: Nicotine and Chlorpyrifos
Slotkin, T. A. (1999) · Environmental Health Perspectives · doi:10.2307/3434474 · Cited by 50
Neonatal treatment with fluoxetine reduces depressive behavior induced by forced swim in adult rats
Mendes‐da‐Silva, C., de Souza, S. L., Medeiros, J. M. B., Freitas-Silva, S. R., Antunes, D. E. C., Cunha, A. D. U., Ribas, V. R., de França, M. F. S., Nogueira, M. I., & Manhães‐de‐Castro, R. (2002) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2002000600008 · Cited by 49
Molecular Mechanisms of Amitraz Mammalian Toxicity: A Comprehensive Review of Existing Data
del Pino, J., Moyano-Cires, P. V., Anadón, M. J., Díaz, M. J. V., Lobo, M., Capo, M. A., & Frejo, M. T. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500534x · Cited by 46
Sertraline delays the somatic growth and reflex ontogeny in neonate rats
Deiró, T. C. B. J., Manhães‐de‐Castro, R., Cabral-Filho, J. E., Medeiros, J. M. B., de Souza, S. L., Marinho, S. M. O. C., Manhães-de-Castro, F. M., Toscano, A. E., Jesus-Deiró, R. A., & Barros, K. M. F. T. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.10.003 · Cited by 46
Zhang, L., Guadarrama, L., Corona-Morales, A. A., Vega‐González, A., Rocha, L., & Escobar, A. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-200606000-00004 · Cited by 47
“There are several experimental evidences suggesting this regulation: 1) serotonin autoregulates development of neurons producing serotonin (7); 2) serotonin exerts effects on the development of target tissue (8); 3) changes in serotoninergic transmission alter gene expression of brain derived neurotrophic factor (9, 1…”
Background5‐HT1A receptor gene C −1019 G polymorphism and amygdala volume in borderline personality disorder
Zetzsche, D. A., Preuss, U. W., Bondy, B., Frodl, T., Zill, P., Schmitt, G., Koutsouleris, N., Rujescu, D., Born, C., Reiser, M. F., et al. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00353.x · Cited by 44
“5-Hydroxytryptamine1A receptors were reported to mediate some of these effects (Duman et al. 2000; Huang & Herbert 2005; Whitaker-Azmitia 1991).”
BackgroundBiomarkers for major depression and its delineation from neurodegenerative disorders
Schneider, B., Prvulovic, D., Oertel‐Knöchel, V., Knöchel, C., Reinke, B., Grexa, M., Weber, B., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.001 · Cited by 45
“…in the proliferative activity in the hippocampus: serotonin (5-HT), which has been shown to exert a neurogenic effect in the CNS during development (Whitaker-Azmitia, 1991), seems to exert a protective role in the hippocampus and attenuates the behavioral consequences of stress by activating…”
Transcriptomics and Other Omics Approaches to Investigate Effects of Xenobiotics on the Placenta
Rosenfeld, C. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.723656 · Cited by 43
Serotonin‐induced activation of the network for locomotion in adult spinal rats
Feraboli‐Lohnherr, D., Barthe, J., & Orsal, D. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990101)55:1 · Cited by 106
Cellular Aspects of Trophic Actions in the Nervous System
Weisenhorn, D. M. V., Roback, J. D., Young, A. N., & Wainer, B. H. (1999) · International review of cytology · doi:10.1016/s0074-7696(08)61388-1 · Cited by 40
Penner, M. R., Leussis, M. P., Pinaud, R., CARREY, N. J., Robertson, H. A., & Brown, R. E. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00308-5 · Cited by 41
Polli, F. S., Scharff, M. B., Ipsen, T. H., Aznar, S., Kohlmeier, K. A., & Andreasen, J. T. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172951 · Cited by 38
Grimaldi, B., Bonnin, A., Fillion, M., Ruat, M., Traiffort, É., & Fillion, G. (1998) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005184 · Cited by 38
Azmitia, E. C., Griffin, W. S. T., Marshak, D. R., Eldik, L. J. V., & Whitaker‐Azmitia, P. M. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61773-2 · Cited by 38
Self-citationWoolston, A.-M., Wedderburn, J. F. S., & Sillar, K. T. (1994) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1994.0011 · Cited by 38
Metadata
- Authors
- Whitaker-Azmitia, P. M.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 43
- Issue
- 4
- Pages
- 553-561
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2230711217
- Cited by
- 226
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, neurotransmitter receptors, brain development, developmental pharmacology
- MeSH terms
- Animals, Brain, Humans, Receptors, Serotonin, Developmental Biology, Receptors, Neurotransmitter
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