The DOI matches its Crossref record.
Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man.
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In the citing paper
“Both THC and CBD are predominantly metabolized, by the liver, through the action of the cytochrome P450 system.104,105”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [105]
In the citing paper
“however, it should be pointed out that previous investigations have not been able to confirm whether there is a direct relationship between plasma levels of cannabinoids, in particular CBD, and their clinical effects (Agurell et al, 1986).”
From Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011) · cites this paper as Agurell et al, 1986
Citations
Cited by
Sorted by citations
Pharmacokinetics and Pharmacodynamics of Cannabinoids
Grotenhermen, F. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342040-00003 · Cited by 1,514
“Mean plasma concentrations of ∆ 9 -tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy- THC (THC-COOH) of six subjects during and after smoking a cannabis cigarette containing about 34mg of THC. [35] THC will significantly contribute to the overall central effects of THC, especially with oral u…”
BackgroundInfluentialBisogno, T., Hanuš, L., PETROCELLIS, L. D., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Marzo, V. D. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,315
“The primary step is hydroxylation on C-7, leading to (7)-7-hydroxy-CBD, followed by further oxidation to (7)-7- carboxy-CBD (Agurell et al., 1986).”
BackgroundHuman Cannabinoid Pharmacokinetics
Huestis, M. A. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790152 · Cited by 1,102
D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Wu, Y.-T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300496 · Cited by 1,024
“Test days were separated by at least 1 week (43 times the elimination half-life of D-9THC) to minimize carryover effects (Wall et al, 1976).”
MethodInfluentialPharmacology and effects of cannabis: A brief review
Ashton, C. H. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.2.101 · Cited by 970
Metadata
- Authors
- Agurell, S., Halldin, M., Lindgren, J. E., Ohlsson, A., Widman, M., Gillespie, H., & Hollister, L.
- ORCID
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 38
- Issue
- 1
- Pages
- 21-43
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2107684761
- Cited by
- 406
- References
- 0
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 45 · 2019: 17 · 2018: 12 · 2017: 11 · 2016: 21 · 2015: 14 · 2014: 14 · 2013: 8 · 2012: 10
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- delta-1-tetrahydrocannabinol, cannabinoids, pharmacokinetics, drug metabolism, human metabolism
- MeSH terms
- Animals, Biotransformation, Cannabidiol, Cannabinoids, Drug Tolerance, Feces, Humans, Kinetics, Dronabinol, Tissue Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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