Human Cannabinoid Pharmacokinetics

Huestis, Marilyn A.

doi:10.1002/cbdv.200790152

Cited by 1,102Cannabis and Cannabinoid ResearchForensic Toxicology and Drug AnalysisPharmacogenetics and Drug Metabolism

Human Cannabinoid Pharmacokinetics

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Huestis, Marilyn A.·2007·Chemistry & Biodiversity

DOI 10.1002/cbdv.200790152PMC PMC2689518

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Both THC and CBD are predominantly metabolized, by the liver, through the action of the cytochrome P450 system.
“Both THC and CBD are predominantly metabolized, by the liver, through the action of the cytochrome P450 system.104,105”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [104]

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Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
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Practical considerations in medical cannabis administration and dosing
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A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
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Authors: Huestis, M. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Huestis, Marilyn A.
ORCID: Huestis, Marilyn A.
Venue: Chemistry & Biodiversity
Publisher: Wiley
Published: 2007-08
Volume: 4
Issue: 8
Pages: 1770-1804
ISSN: 1612-1872 (ISSN-L)
1612-1880
DOI: 10.1002/cbdv.200790152
PMC: PMC2689518
OpenAlex: W2169754532
Cited by: 1,102
References: 173
Citations by year: 2026: 79 · 2025: 97 · 2024: 77 · 2023: 114 · 2022: 109 · 2021: 121 · 2020: 132 · 2019: 117 · 2018: 70 · 2017: 56 · 2016: 42 · 2015: 31 · 2014: 14 · 2013: 13 · 2012: 10
FWCI: 0.35
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 20 d)
Locations: Chemistry & Biodiversity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (Z01DA000413, Z01DA000415, Z01DA000412)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: cannabinoids, pharmacokinetics, human metabolism, drug absorption, distribution, metabolism, excretion
MeSH terms: Cannabinoids, Humans, Sweat

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