Polyhydroxylated alkaloids—Natural occurrence and therapeutic applications

Isolation of 1,5-dideoxy-1,5-imino-D-mannitol from culture broth of Streptomyces species.

Ezure, Y., OJIMA, N., Konno, K., MIYAZAKI, K., Yamada, N., Sugiyama, M., ITOH, M., & Nakamura, T. (1988) · The Journal of Antibiotics · doi:10.7164/antibiotics.41.1142 · Cited by 21

Mannoside storage and axonal dystrophy in sensory neurones of swainsonine-treated rats: Morphogenesis of lesions

Huxtable, C. R. R., & Dorling, P. R. (1985) · Acta Neuropathologica · doi:10.1007/bf00688958 · Cited by 21

Chemicals in aroids: a survey, including new results for polyhydroxy alkaloids and alkylresorcinols

Dring, J. V., Kite, G. C., Nash, R. J., & Reynolds, T. (1995) · Botanical Journal of the Linnean Society · doi:10.1111/j.1095-8339.1995.tb02373.x · Cited by 21

Uptake and metabolism of BuCast: a glycoprotein processing inhibitor and a potential anti-HIV drug

Kang, M. S. (1996) · Glycobiology · doi:10.1093/glycob/6.2.209 · Cited by 21

Phytochemical diversity : a source of new industrial products

Wrigley, S. K. (1997) · Cited by 20

Measuring swainsonine in serum of cancer patients: phase I clinical trial

Baptista, J., Goss, P. E., Nghiem, M. P., Křepinský, J. J., Baker, M., & Dennis, J. W. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.3.426 · Cited by 20

The structures of a .BETA.-galactosidase inhibitor, galactostatin, and its derivatives.

Miyake, Y., & Ebata, M. (1988) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.52.661 · Cited by 20

Polyhydroxy Plant Alkaloids as Glycosidase Inhibitors and Their Possible Ecological Role

Fellows, L. E., Evans, S. V., Nash, R. J., & Bell, E. A. (1986) · ACS symposium series · doi:10.1021/bk-1986-0296.ch006 · Cited by 20

Revised structure of a homonojirimycin isomer from Aglaonema treubii: First example of a naturally occurring α-homoallonojirimycin

Martin, O. R., Compain, P., Kizu, H., & Asano, N. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(99)00551-x · Cited by 18

Isolation of 2R,5R-Dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) from the Fermentation Broth ofStreptomycessp. KSC-5791

Watanabe, S., Kato, H., Nagayama, K., & Abe, H. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.936 · Cited by 17

X-ray crystal structure of the hydrochloride of 6-epicastanospermine [(1S,6R,7R,8R,8aR)-1,6,7,8-tetrahydroxy-octahydroindolizine]

Nash, R. J., Fellows, L. E., Girdhar, A., Fleet, G. W. J., Peach, J. M., Watkin, D. J., & Hegarty, M. P. (1990) · Phytochemistry · doi:10.1016/0031-9422(90)85470-z · Cited by 17

Differentiation of glycosidase activity in some Hemiptera and Lepidoptera by means of castanospermine and other polyhydroxy alkaloids

Scofield, A. M., Witham, P., Nash, R. J., Kite, G. C., & Fellows, L. E. (1995) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(95)00069-j · Cited by 16

The toxicity of Castanospermum australe seeds for cattle

McKENZIE, R., Reichmann, K. G., Dimmock, C. K., DUNSTER, P. J., & TWIST, J. (1988) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.1988.tb14291.x · Cited by 14

Synergistic interaction between castanospermine and tacrolimus in a rat heart allograft model

Grochowicz, P., Hibberd, A. D., Bowen, K. M., Clark, D. A., Pang, G., Cowden, W. B., Chou, T., Grochowicz, L., & Smart, Y. C. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(96)00488-5 · Cited by 12

Synergistic Inhibition of Human Immunodeficiency Virus Type 1in vitroby 6-0-butanoylcastanospermine (MDL 28574) in Combination with Inhibitors of the Virus-Encoded Reverse Transcriptase and Proteinase

Taylor, D. L., Brennan, T., BRIDGES, C. G., Kang, M. S., & Tyms, A. S. (1995) · Antiviral chemistry & chemotherapy · doi:10.1177/095632029500600303 · Cited by 12

Interaction of swainsonine with lymphoid and highly perfused tissues: a pharmacokinetics explanation for sustained immunomodulation.

Bowen, D., Wm, S., Cd, B., & De, H. (1997) · PubMed · Cited by 11

The immunologic and toxic effects of chronic locoweed (Astragalus lentiginosus) intoxication in cattle.

Stegelmeier, B. L., Snyder, P. W., James, L. F., Panter, K. E., Molyneux, R. J., Gardner, D. R., Ralphs, M. H., Pfister, J. A., Garland, T., & Barr, A. C. (1998) · Cited by 10

Swainsonine: a new antineoplastic immunomodulator.

Mohla, S., Humphries, M. J., White, S. L., Matsumoto, K., Newton, S. A., Sampson, C. C., Bowen, D., & Olden, K. (1989) · PubMed Central · Cited by 10

Approach Toward a Generic Treatment of Gram-Negative Infections: Synthesis of Haptens for Catalytic Antibody Mediated Cleavage of the Interglycosidic Bond in Lipid A

van den Berg, R. J. B. H. N., Noort, D., Milder‐Enacache, E. S., van der MAREL, G. A., BOOM, J. H. V., & Benschop, H. P. (1999) · European Journal of Organic Chemistry · doi:10.1002/(sici)1099-0690(199910)1999:10 · Cited by 10

Differential effects of glycoprotein processing inhibition on experimental metastasis formation by T24-H-ras transformed fibroblasts

Spearman, M. A., Damen, J. E., Kolodka, T. M., Greenberg, A. H., Jamieson, J., & Wright, J. (1991) · Cancer Letters · doi:10.1016/0304-3835(91)90056-n · Cited by 8

Distribution of active α- and β-subunits of β-N-acetylhexosaminidase as a function of leukaemic cell types

Martino, S., Emiliani, C., Tabilio, A., Falzetti, F., Stirling, J. L., & Orlacchio, A. (1997) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(96)00116-x · Cited by 7

TheN-Benzyl Derivative of the Glucosidase Inhibitor 1-Deoxynojirimycin Shows a Prolonged Half-Life and a More Complete Oral Absorption in the Rat Compared with theN-Methyl Analog

Faber, E. D., van den Broek, L. A. G. M., Oosterhuis, E. Z., Stok, B. P., & Meijer, D. K. F. (1998) · Drug Delivery · doi:10.3109/10717549809052021 · Cited by 7

Castanospermine-Induced Deficiency of Lysosomal β-D-Glucosidase: A Model of Gaucher’s Disease in Fibroblasts

di Bello, I. C., Mann, D., Nash, R. J., & WINCHESTER, B. G. (1988) · Springer eBooks · doi:10.1007/978-1-4613-1029-7_79 · Cited by 7

Experimental approaches for the prevention of hematogenous metastasis.

Olden, K., Sl, W., Mohla, S., Newton, S. A., Yasuda, Y. U., Bowen, D., & Humphries, M. J. (1989) · PubMed · Cited by 6

Castanospermine, an inhibitor of glycoprotein processing, prolongs pancreaticoduodenal allograft survival.

Grochowicz, P., Km, B., Hibberd, A. D., Da, C., Cowden, W. B., & Willenborg, D. O. (1992) · PubMed · Cited by 5

Castanospermine, an oligosaccharide-processing inhibitor, reduces membrane expression of adhesion molecules and prolongs heart allograft survival in rats

Hibberd, A. D., Grochowicz, P., Smart, Y. C., Bowen, K. M., Clark, D. A., Cowden, W. B., & Willenborg, D. O. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(96)00487-3 · Cited by 4

ChemInform Abstract: Studies on the Constituents of Broussonetia Species. Part 5. Two New Pyrrolidine Alkaloids, Broussonetines K and L, as Inhibitors of Glycosidase, from Broussonetia kazinoki SIEB.

Shibano, M., Nakamura, S., Motoya, N., & Kusano, G. (1999) · ChemInform · doi:10.1002/chin.199942234 · Cited by 4

Casuarine-6-α-D-glucoside from Casuarina equisetifolia and Eugenia jambolana

Wormald, Nash, R. J., Watson, A., BHADORIA, B. K., Langford, R. A., Sims, M., & FLEET, G. W. J. (1996) · Cited by 4

Castanospermine downregulates membrane expression of adhesion molecules in heart allograft recipients.

Hibberd, A. D., Grochowicz, P., Smart, Y. C., Bowen, K. M., Clark, D. A., Purdon, B., Willenborg, D. O., & Cowden, W. B. (1995) · PubMed · Cited by 3

ChemInform Abstract: Synthesis of Casuarines (Pentahydroxylated Pyrrolizidines) by Sodium Hydrogen Telluride‐Induced Cyclizations of Azidodimesylates.

Bell, A. A., Pickering, L., WATSON, A. A., Nash, R. J., Pan, Y., Elbein, A. D., & Fleet, G. W. J. (1997) · ChemInform · doi:10.1002/chin.199746222 · Cited by 2

ChemInform Abstract: Isolation of 7a‐Epialexaflorine from Leaves of Alexa grandiflora: A Unique Pyrrolizidine Amino Acid with a Carboxylic Acid Substituent at C‐3.

Pereira, A. C. D. S., Kaplan, M. A. C., Maia, J. G. S., Gottlieb, O. R., Nash, R. J., Fleet, G. W. J., PEARCE, L., Watkin, D. J., & Scofield, A. M. (1991) · ChemInform · doi:10.1002/chin.199141243 · Cited by 2

Castanospermine modifies expression of adhesion molecules in allograft recipients.

Grochowicz, P., Smart, Y. C., Bowen, K. M., Hibberd, A. D., Clark, D. A., Cowden, W. B., & Willenborg, D. O. (1993) · PubMed · Cited by 2

Enzymatic Synthesis of 4-O-α- d -Glucopyranosyl-moranoline

Ezure, Y. (1985) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1985.10867011 · Cited by 1

Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review

Kuete, V. (2010) · Planta Medica · doi:10.1055/s-0030-1250027 · Cited by 716

α- and β-Glucosidase inhibitors: chemical structure and biological activity

de Melo, E. B., Gomes, A. D. S., & Carvalho, I. (2006) · Tetrahedron · doi:10.1016/j.tet.2006.08.055 · Cited by 548

Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring‐Closing Metathesis as a Key Step

Felpin, F., & Lebreton, J. (2003) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200300193 · Cited by 443

Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans

Kimura, T., Nakagawa, K., Kubota, H., Kojima, Y., Goto, Y., Yamagishi, K., Oita, S., Oikawa, S., & Miyazawa, T. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062680g · Cited by 342

The Biological Activity of Natural Alkaloids against Herbivores, Cancerous Cells and Pathogens

Thawabteh, A. M., Juma, S., Bader, M., Karaman, D., Scrano, L., Bufo, S. A., & Karaman, R. (2019) · Toxins · doi:10.3390/toxins11110656 · Cited by 335

Isolation, characterization and analysis of polyhydroxy alkaloids

Molyneux, R. J. (1993) · Phytochemical Analysis · doi:10.1002/pca.2800040502 · Cited by 24

The biological activity of polyhydroxyalkaloids from plants

Fellows, L. E. (1986) · Pesticide Science · doi:10.1002/ps.2780170518 · Cited by 54

Polyhydroxylated Alkaloids with Lipophilic Moieties as Glycosidase Inhibitors from Higher Plants

Shibano, M., Tsukamoto, D., & Kusano, G. (2002) · ChemInform · doi:10.1002/chin.200242280 · Cited by 1

Polyhydroxy Plant Alkaloids as Glycosidase Inhibitors and Their Possible Ecological Role

Fellows, L. E., Evans, S. V., Nash, R. J., & Bell, E. A. (1986) · ACS symposium series · doi:10.1021/bk-1986-0296.ch006 · Cited by 20

PHARMACOLOGICAL PROPERTIES OF POLYHYDROXY ALKALOIDS: A MINI-REVIEW

Terengganu, U. M., ISMAIL, Z., Ahmad, A., & Terengganu, U. M. (2024) · Journal of Sustainability Science and Management · doi:10.46754/jssm.2024.12.010