Importance and prevention of malaria in pregnancy
Abstract
Malaria in pregnancy is one of the most important preventable causes of low birthweight deliveries worldwide. It is also a major cause of severe maternal anaemia contributing to maternal mortality. It is estimated that 40% of the world's pregnant women are exposed to malaria infection during pregnancy. The clinical features of Plasmodium falciparum malaria in pregnancy depend to a large extent on the immune status of the woman, which in turn is determined by her previous exposure to malaria. In pregnant women with little or no pre-existing immunity, such as women from non-endemic areas or travellers to malarious areas, infection is associated with high risks of severe disease with maternal and perinatal mortality. Women are at particular risk of cerebral malaria, hypoglycaemia, pulmonary oedema and severe haemolytic anaemia. Fetal and perinatal loss has been documented to be as high as 60-70% in non-immune women with malaria. Adults who are long-term residents of areas of moderate or high malaria transmission, including large parts of sub-Saharan Africa, usually have a high level of immunity to malaria. Infection is frequently asymptomatic and severe disease is uncommon. During pregnancy this immunity to malaria is altered. Infection is still frequently asymptomatic, so may go unsuspected and undetected, but is associated with placental parasitization. Malaria in pregnancy is a common cause of severe maternal anaemia and low birthweight babies, these complications being more…
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- Authors
- Shulman, C. E., & Dorman, E. K.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Homerton University Hospital (GB)
- ORCID
- Shulman, Caroline E.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01
- Volume
- 97
- Issue
- 1
- Pages
- 30-35
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W1978712833
- Cited by
- 148
- References
- 5
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 13
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- malaria in pregnancy, Plasmodium falciparum, low birth weight, maternal mortality, cerebral malaria, malaria immunity, chemoprophylaxis, intermittent preventive treatment, insecticide-treated bednets, perinatal mortality, primigravida
- MeSH terms
- Anemia, Antimalarials, Bedding and Linens, Female, Fetal Growth Retardation, Humans, Infant, Low Birth Weight, Infant, Newborn, Insect Control, Obstetric Labor, Premature, Maternal Mortality, Poverty Areas, Pregnancy, Pregnancy Complications, Infectious, Prenatal Diagnosis, Travel, Pregnancy Complications, Parasitic, HIV Infections, Malaria, Falciparum, Endemic Diseases
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