Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine against Malaria and Anemia in Pregnant Women
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The effectiveness of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) against malaria and anemia is unclear because of the spread of SP-resistant Plasmodium falciparum. This study evaluates the effectiveness of IPTp-SP among pregnant women attending the antenatal clinic at Korle-Bu Teaching Hospital in Accra, Ghana. A cross-sectional study comparing malaria and anemia prevalence among pregnant women using IPTp-SP with non-IPTp-SP users was conducted during June–August 2009. A total of 363 pregnant women (202 of IPTp users and 161 non-IPTp users) were recruited. A total of 15.3% of IPTp users had malaria compared with 44.7% of non-IPTp users (P < 0.001). A total of 58.4% of non-IPTp users were anemic compared with 22.8% of IPTp users (P < 0.001). When we controlled for other variables, the difference in the prevalence of malaria (odds ratio = 0.18, 95% confidence interval = 0.08–0.37) and anemia (odds ratio = 0.20, 95% confidence interval = 0.12–0.34) remained significant. The recommended IPTp-SP regimen is useful in preventing malaria and anemia among pregnant women in Ghana.
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Preventing malaria infection by intermittent preventive treatment during pregnancy reduces the risk of anaemia.
“Preventing malaria infection by intermittent preventive treatment during pregnancy (IPTp) reduces the risk of anaemia.27,37–38”
From Malaria in pregnancy. (2013) · cites this paper as [27]
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- Authors
- Wilson, N. O., Ceesay, F. K., Obed, S. A., Adjei, A. A., Gyasi, R. K., Rodney, P., Ndjakani, Y., Anderson, W. A., Lucchi, N. W., & Stiles, J. K.
- Affiliations
- Morehouse School of Medicine (US)
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2011-07-01
- Volume
- 85
- Issue
- 1
- Pages
- 12-21
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC3122337
- OpenAlex
- W2137587975
- Cited by
- 58
- References
- 83
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Howard (Howard University) (submittedVersion)
- Funders
- National Institutes of Health (5s06gm008248-23)
- National Institute of General Medical Sciences (SO6-GM08248, R25GM058268, S06 GM-008248)
- Fogarty International Center (R21TW006804)
- National Center for Research Resources (RR 03034, G12RR003034, R25RR017694)
- National Institute on Minority Health and Health Disparities (S21MD000101)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- intermittent preventive treatment, sulfadoxine-pyrimethamine, IPTp-SP, malaria in pregnancy, anemia in pregnancy, Plasmodium falciparum, sulfonamide resistance, prenatal care, pregnant women, malaria prevention, Ghana
- MeSH terms
- Adolescent, Adult, Anemia, Antimalarials, Drug Combinations, Female, Humans, Malaria, Pregnancy, Pyrimethamine, Surveys and Questionnaires, Sulfadoxine, Pregnancy Complications, Parasitic, Young Adult
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