CoChat
Sign Up
Cited by 111Neuroendocrine Tumor Research AdvancesAdrenal and Paraganglionic TumorsPituitary Gland Disorders and Treatments

Adrenal lesion in multiple endocrine neoplasia type 1

Skogseid, Britt, Rastad, Jonas, Gobl, Anders, Larsson, Catharina, Backlin, Karin, Juhlin, Claes, Åkerström, Göran, Öberg, Kjell·1995·Surgery
DOI 10.1016/s0039-6060(05)80117-5
Open this paper in CoChat — free account

Abstract

Background Multiple endocrine neoplasia (MEN) type 1 is accompanied by adrenal involvement, but characteristics and clinical handling of this lesion have been insufficiently explored.Methods Patients with MEN 1 (n = 43) were monitored (mean, 6.3 years) with annual biochemical and radiologic adrenal evaluation. Adrenal specimens were examined by in situ RNA-RNA hybridization for expression of the MEN1 candidate gene phospholipase C beta 3 (PLC beta 3) and immunostaining for insulin-like growth factor-1 receptor.Results Altogether 17 patients (40%) displayed adrenal enlargement, which was limited to the adrenal cortex and showed signs of progression, marked atypia, and cancer development in three of them. Only the carcinoma exhibited adrenocortical hormone excess. PLC beta 3 was expressed in the hyperplastic and adenomatous proliferation but not the carcinoma. Pancreatic endocrine tumors with insulin-proinsulin excess were overrepresented in the patients with adrenocortical involvement, but significant insulin-like growth factor-1 receptor immunoreactivity was restricted to the carcinoma.Conclusions The prevalent adrenocortical lesion associated with MEN 1 requires regular attention because of malignant potential. It was unrelated to loss of constitution heterozygosity for the MEN1 locus (11q13) and PLC beta 3 expression, except for the cortical carcinoma exhibiting allelic losses involving also the Wiedemann-Beckwith gene at 11p15. Mechanisms for mitogenic relationships between the pancreatic and adrenal lesions of MEN 1 demand further clarification.

Integrity signals

Registry

Crossref · 10.1016/s0039-6060(05)80117-5

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Associated adrenal lesions, mainly ACAs and uni- or bilateral hyperplasia, occur in 20% to 55% of MEN1 cases.

    “Associated adrenal lesions, mainly ACAs and uni- or bilateral hyperplasia, occur in 20% to 55% of MEN1 cases (45–48).”

    From Adrenocortical carcinoma (2014) · cites this paper as [46]

  • A small fraction of patients with MEN1 will develop ACC.

    “A small fraction of patients with MEN1 will develop ACC (46–51).”

    From Adrenocortical carcinoma (2014) · cites this paper as [46]

Cites

Flagged first, then by citations

3 of the 20 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Skogseid, B., Rastad, J., Gobl, A., Larsson, C., Backlin, K., Juhlin, C., Åkerström, G., & Öberg, K.
Affiliations
Karolinska University Hospital (SE)
Corresponding author
Skogseid, Britt
ORCID
Venue
Surgery
Publisher
Elsevier BV
Published
1995-12
Volume
118
Issue
6
Pages
1077-1082
ISSN
0039-6060 (ISSN-L)
DOI
10.1016/s0039-6060(05)80117-5
OpenAlex
W1972860148
Cited by
111
References
20
Citations by year
2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 7 · 2015: 4 · 2013: 4 · 2012: 2
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
multiple endocrine neoplasia type 1, adrenal mass, adrenocortical carcinoma, adrenal hyperplasia, IGF-1 receptor, pancreatic neuroendocrine tumors, Beckwith-Wiedemann syndrome, 11p15, tumor progression
MeSH terms
Adrenal Gland Diseases, Adrenal Gland Neoplasms, Adrenal Glands, Adult, Aged, Aged, 80 and over, Female, Humans, Immunoenzyme Techniques, Isoenzymes, Male, Middle Aged, Pancreatic Diseases, Type C Phospholipases, RNA, Messenger, In Situ Hybridization, Receptor, IGF Type 1, Multiple Endocrine Neoplasia Type 1, Phospholipase C beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review