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Cited by 210Adrenal and Paraganglionic TumorsRenal cell carcinoma treatmentAdrenal Hormones and Disorders

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Role of reoperation in recurrence of adrenal cortical carcinoma: Results from 188 cases collected in the Italian National Registry for Adrenal Cortical Carcinoma

Bellantone, Rocco, Ferrante, Angela, Boscherini, Mauro, Lombardi, Celestino P, Crucitti, Pierfilippo, Crucitti, Francesco, Favia, Gennaro, Borrelli, Domenico, Boffi, Lamberto, Capussotti, Luigi, Carbone, Giovanni, Casaccia, Mario, Cavallaro, Antonio, Del Gaudio, Antonio, Dettori, Giuseppe, Di Giovanni, Vincenzo, Mazziotti, Alighiero, Marrano, Domenico, Masenti, Ettore, Miccoli, Paolo, Mosca, Franco, Mussa, Antonio, Petronio, Renato, Piat, Gianpaolo, Ruberti, Ugo, Serio, Giuseppe, Marzano, Luigi·1997·Surgery
DOI 10.1016/s0039-6060(97)90229-4
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Abstract

Background Recurrence of adrenal cortical carcinoma (ACC) after radical surgery is a common finding. Although successful reoperations have been reported with encouraging results, most published experiences are anecdotal and based on few cases. We report the results of surgical treatment for recurrent ACC in a multiinstitutional series.Methods One hundred eighty-eight cases of ACC were collected in a national registry. A complete follow-up was obtained in 179 cases. At initial diagnosis 92 patients had local disease (stage I or II). One hundred seventy patients underwent surgical treatment, considered radical in 140; in this group, recurrent disease was observed in 52 cases (37%) after a mean disease-free interval of 21.7 months.Results Adjuvant chemotherapy was ineffective in ameliorating the prognosis. The mean survival in 20 patients who underwent reoperation was significantly higher (15.85 +/- 14.9 months) than in nonreoperated cases (3.2 +/- 2.9 months). Five-year actuarial survival in reoperated patients is significantly better than in nonreoperated patients (49.7% versus 8.3%, respectively).Conclusions Although the prognosis of this tumor is still poor, surgery is the only effective therapy; reoperation allows survival comparable to that observed in patients without recurrent disease. An aggressive strategy for recurrent ACC is advisable until prospective studies demonstrate a real effectiveness for chemotherapy.

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Crossref · 10.1016/s0039-6060(97)90229-4

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Metadata

Authors
Bellantone, R., Ferrante, A., Boscherini, M., Lombardi, C. P., Crucitti, P., Crucitti, F., Favia, G., Borrelli, D., Boffi, L., Capussotti, L., Carbone, G., Casaccia, M., Cavallaro, A., Del Gaudio, A., Dettori, G., Di Giovanni, V., Mazziotti, A., Marrano, D., Masenti, E., Miccoli, P., Mosca, F., Mussa, A., Petronio, R., Piat, G., Ruberti, U., Serio, G., & Marzano, L.
Affiliations
Agostino Gemelli University Polyclinic (IT)
Corresponding author
Ferrante, Angela
ORCID
Venue
Surgery
Publisher
Elsevier BV
Published
1997-12
Volume
122
Issue
6
Pages
1212-1218
ISSN
0039-6060 (ISSN-L)
DOI
10.1016/s0039-6060(97)90229-4
OpenAlex
W2084654797
Cited by
210
References
28
Citations by year
2026: 2 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 13 · 2014: 17 · 2013: 8 · 2012: 13
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenocortical carcinoma, tumor recurrence, reoperation, adjuvant chemotherapy, survival, prognosis, disease-free interval
MeSH terms
Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Reoperation

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