The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Role of reoperation in recurrence of adrenal cortical carcinoma: Results from 188 cases collected in the Italian National Registry for Adrenal Cortical Carcinoma
Abstract
Background Recurrence of adrenal cortical carcinoma (ACC) after radical surgery is a common finding. Although successful reoperations have been reported with encouraging results, most published experiences are anecdotal and based on few cases. We report the results of surgical treatment for recurrent ACC in a multiinstitutional series.Methods One hundred eighty-eight cases of ACC were collected in a national registry. A complete follow-up was obtained in 179 cases. At initial diagnosis 92 patients had local disease (stage I or II). One hundred seventy patients underwent surgical treatment, considered radical in 140; in this group, recurrent disease was observed in 52 cases (37%) after a mean disease-free interval of 21.7 months.Results Adjuvant chemotherapy was ineffective in ameliorating the prognosis. The mean survival in 20 patients who underwent reoperation was significantly higher (15.85 +/- 14.9 months) than in nonreoperated cases (3.2 +/- 2.9 months). Five-year actuarial survival in reoperated patients is significantly better than in nonreoperated patients (49.7% versus 8.3%, respectively).Conclusions Although the prognosis of this tumor is still poor, surgery is the only effective therapy; reoperation allows survival comparable to that observed in patients without recurrent disease. An aggressive strategy for recurrent ACC is advisable until prospective studies demonstrate a real effectiveness for chemotherapy.
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“data from other studies note their influence on outcome, although subsequent recurrence is expected (267, 268).”
From Adrenocortical carcinoma (2014) · cites this paper as [267]
In the citing paper
“The outcomes after surgical resection alone have remained suboptimal (11, 244, 267, 269–273).”
From Adrenocortical carcinoma (2014) · cites this paper as [267]
In the citing paper
“Even with ostensibly complete resections, rates of local recurrence have typically ranged from at least 19% to 34% in those patients with no residual disease after surgery (244, 267, 270).”
From Adrenocortical carcinoma (2014) · cites this paper as [267]
Citations
Cites
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PAEDIATRIC ADRENOCORTICAL CARCINOMA: A CASE REPORT
Amir, M. S., Ali, M., Rehman, A., Ghayyour, F., Malik, I., & Khattak, T. G. (2023) · Journal of Postgraduate Medical Institute · doi:10.54079/jpmi.37.2.3131
The problem of adrenocortical cancer therapy
Андреевна, К. А., Горбунова, В. А., & Переводчикова, Н. И. (2014) · Russian Journal of Oncology · doi:10.17816/onco40131
Adrenocortical cancer: late diagnosis of the disease on the example of a clinical case. Case report
Starostina, E. A. (2023) · Terapevticheskii arkhiv · doi:10.26442/00403660.2023.12.202430
Adrenal Multidisipliner Güncel Yaklaşım
Özen, F. Z., Özer, M., Özsoy, Ç., Binnetoğlu, E., Alparslan, A. Ş., Budak, E. S., Kök, E. V., Çetinkaya, G. S., Durmuş, M. E., Köker, G., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.2992
Urusova, L. S., Владимеровна, П. Н., Porubayeva, E. E., Elfimova, A. R., Beltsevich, D. G., Chevais, A., Демура, Т. А., & Mokrysheva, N. G. (2024) · Russian Journal of Archive of Pathology · doi:10.17116/patol20248603121
Mittal, A., Amer, L., Ayodele, O., Radi, S., Li, X., Araújo, D. V., Malone, E. R., Al-Ezzi, E. M., Pasternak, J. D., Mete, Ö., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-5278081/v1
Debois, J. M. (2000) · Springer eBooks · doi:10.1007/978-94-011-4100-0_7
Il trattamento del carcinoma del surrene
Sperone, P., Berruti, A., & Dogliotti, L. (2007) · L Endocrinologo · doi:10.1007/bf03344590
Mittal, A., Amer, L. G., Ayodele, O., Radi, S., Li, X., Araújo, D. V., Malone, E. R., Al-Ezzi, E. M., Pasternak, J., Mete, Ö., et al. (2026) · BJC Reports · doi:10.1038/s44276-026-00237-7
Metadata
- Authors
- Bellantone, R., Ferrante, A., Boscherini, M., Lombardi, C. P., Crucitti, P., Crucitti, F., Favia, G., Borrelli, D., Boffi, L., Capussotti, L., Carbone, G., Casaccia, M., Cavallaro, A., Del Gaudio, A., Dettori, G., Di Giovanni, V., Mazziotti, A., Marrano, D., Masenti, E., Miccoli, P., Mosca, F., Mussa, A., Petronio, R., Piat, G., Ruberti, U., Serio, G., & Marzano, L.
- Affiliations
- Agostino Gemelli University Polyclinic (IT)
- Corresponding author
- Ferrante, Angela
- Venue
- Surgery
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 122
- Issue
- 6
- Pages
- 1212-1218
- ISSN
- 0039-6060 (ISSN-L)
- OpenAlex
- W2084654797
- Cited by
- 210
- References
- 28
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 13 · 2014: 17 · 2013: 8 · 2012: 13
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Oncology › Renal cell carcinoma treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenocortical carcinoma, tumor recurrence, reoperation, adjuvant chemotherapy, survival, prognosis, disease-free interval
- MeSH terms
- Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Reoperation
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