The DOI matches its Crossref record; 531 of the 550 references it cites were found in a registry or an index.
Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies
Abstract
Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the United States, western Europe, Australia, and Japan. Despite intensive research, the precise etiology of molecular events that underlie age-related macular degeneration is poorly understood. However, investigations on parallel fronts are addressing this prevalent public health problem. Sophisticated biochemical and biophysical techniques have refined our understanding of the pathobiology of drusen, geographic atrophy, and retinal pigment epithelial detachments. Epidemiological identification of risk factors has facilitated an intelligent search for underlying mechanisms and fueled clinical investigation of behavior modification. Gene searches have not only brought us to the cusp of identifying the culpable gene loci in age-related macular degeneration, but also localized genes responsible for other macular dystrophies. Recent and ongoing investigations, often cued by tumor biology, have revealed an important role for various growth factors, particularly in the neovascular form of the condition. Transgenic and knockout studies have provided important mechanistic insights into the development of choroidal neovascularization, the principal cause of vision loss in age-related macular degeneration. This in turn has culminated in preclinical and clinical trials of directed molecular interventions.
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“The pathogenesis of age-related macular degeneration is not well known, although a number of theories have been put forward, including oxidative stress, mitochondrial dysfunction, and inflammatory processes.9–13”
From Age-related macular degeneration (2008) · cites this paper as [10]
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1 retracted
Fujiyama, S., Matsubara, H., Nozawa, Y., Maruyama, K., Mori, Y., Tsutsumi, Y., Masaki, H., Uchiyama, Y., Koyama, Y., Nose, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.1.22 · Cited by 203
RetractedVascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,162
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
Requirement of Vascular Integrin α v β 3 for Angiogenesis
Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020
Research works printed but not linked: 16
- Age-Related Eye Disease Study Research Group, 2000, Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3, Ophthalmology, 107, 2224
- Applegate, 2001, A treatment trial for geographic atrophy from AMD: The GAARD Study, Invest Ophthalmol Vis Sci, 42, S230
- Baffi, 2001, The recruitment of inflammatory cells into vascular endothelial growth factor (VEGF) induced choroidal neovascularization (CNV) in rat, Invest Ophthalmol Vis Sci, 42, S227
- Becerra, 2001, Pigment epithelium-derived factor (PEDF) in the monkey eye: apical secretion from the retinal pigment epithelium, Invest Ophthalmol Vis Sci, 42, S772
- Blodi, 2001, Effects of prinomastat (AG3340), an angiogenesis inhibitor, in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration, Invest Ophthalmol Vis Sci, 41, S311
- Hanssen, 1930, Zur anatomie der scheibenformigen degeneration der netzhaumitte, Z Augenh, 72, 360
- Hegner, 1916, Retinitis exsudativa bei Lymphogranulomatosis, Klin Monatsbl Augenheil, 57, 27
- Holz, 1994, Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors, Ophthalmology, 101, 1522, 10.1016/S0161-6420(94)31139-0 · DOI
- Luna, 1996, Antagonists of integrin αvβ3 inhibit retinal neovascularization in a murine model, Lab Invest, 75, 563
- Maguire, 2001, Results of the age-related macular degeneration and thalidomide study (AMDATS), Invest Ophthalmol Vis Sci, 42, S233
- McFarlane, 2001, Advanced glycation endproducts (AGEs) modulate cathepsin D expression in retinal pigment epithelium (RPE): implications for age-related dysfunction, Invest Ophthalmol Vis Sci, 42, S414
- Nozaki, 2001, Immunolocalization of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in choroidal neovascularization of human, Invest Ophthalmol Vis Sci, 42, S228
- Paul, 1927, Choroiditis exsudativa under dem bilde der scheibenformigen entartung der netzhautmitte, Z Augenh, 63, 205
- Razavi, 2001, Expression of integrins avb3 and avb5 in human choroidal neovascular membranes, Invest Ophthalmol Vis Sci, 42, S773
- Spandau, 2000, High expression of angiogenic chemokines in choroidal neovascularization membranes, Invest Ophthalmol Vis Sci, 41, S836
- Tanemura, 2001, Estrogen may enhance VEGFR-2 expression in the process of laser-induced CNV formation, Invest Ophthalmol Vis Sci, 42, S96
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Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Ng, E. W. M., Shima, D. T., Calias, P., Cunningham, E. T., Guyer, D. R., & Adamis, A. P. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1955 · Cited by 1,629
Self-citationGenomewide Association Studies and Assessment of the Risk of Disease
Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512
Metadata
- Authors
- Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- Venue
- Survey of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 48
- Issue
- 3
- Pages
- 257-293
- ISSN
- 0039-6257 (ISSN-L)
- OpenAlex
- W2016584341
- Semantic Scholar
- 966a19179595c3864062c4154d58b52e09b9a723
- Cited by
- 959
- References
- 550
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 22 · 2023: 37 · 2022: 31 · 2021: 42 · 2020: 35 · 2019: 38 · 2018: 42 · 2017: 56 · 2016: 46 · 2015: 57 · 2014: 49 · 2013: 46 · 2012: 48
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Survey of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, drusen, geographic atrophy, retinal pigment epithelium, choroidal neovascularization, genetic risk factors, macular dystrophy, growth factors, gene therapy, treatment options, legal blindness, risk factors
- MeSH terms
- Animals, Disease Models, Animal, Humans, Macular Degeneration, Mice, Transgenic, Risk Factors, Mice, Knockout, Mice
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