Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,162

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease

Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8

(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285

Requirement of Vascular Integrin α v β 3 for Angiogenesis

Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

The Retinal Pigment Epithelium in Visual Function

Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

Ng, E. W. M., Shima, D. T., Calias, P., Cunningham, E. T., Guyer, D. R., & Adamis, A. P. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1955 · Cited by 1,629

Genomewide Association Studies and Assessment of the Risk of Disease

Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512

Mechanisms of Age-Related Macular Degeneration

Ambati, J., & Fowler, B. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.018 · Cited by 1,062

Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

Bhutto, I. A., & Lutty, G. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.005 · Cited by 1,028

The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina

SanGiovanni, J. P., & Chew, E. Y. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.002 · Cited by 905

Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration

Jia, Y., Bailey, S. T., Wilson, D. J., Tan, O., Klein, M. L., Flaxel, C. J., Potsaid, B. M., Liu, J. J., Lu, C. D., Kraus, M. F., et al. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2014.01.034 · Cited by 733

Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

Jia, Y., Bailey, S. T., Hwang, T. S., McClintic, S. M., Gao, S. S., Pennesi, M. E., Flaxel, C. J., Lauer, A. K., Wilson, D. J., Joachim Hornegger, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500185112 · Cited by 675

Drusen complement components C3a and C5a promote choroidal neovascularization

Nozaki, M., Raisler, B. J., Sakurai, E., Sarma, J. V., Barnum, S. R., Lambris, J. D., Chen, Y., Zhang, K., Ambati, B. K., Baffi, J. Z., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408835103 · Cited by 650

An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B. C., Kuziel, W. A., Rollins, B. J., & Ambati, B. K. (2003) · Nature Medicine · doi:10.1038/nm950 · Cited by 631

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601

Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors

Saint‐Geniez, M., Maharaj, A. S. R., Walshe, T. E., Tucker, B. A., Sekiyama, E., Kurihara, T., Darland, D. C., Young, M. J., & D'Amore, P. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003554 · Cited by 622

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.036 · Cited by 592

The molecular basis of human retinal and vitreoretinal diseases

Berger, W., Kloeckener‐Gruissem, B., & Neidhardt, J. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.03.004 · Cited by 609

Immunology of age-related macular degeneration

Ambati, J., Atkinson, J. P., & Gelfand, B. D. (2013) · Nature reviews. Immunology · doi:10.1038/nri3459 · Cited by 606

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

Saint‐Geniez, M., Kurihara, T., Sekiyama, E., Maldonado, A. E., & D'Amore, P. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905010106 · Cited by 535

Age-related macular degeneration

Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542

Oxidative stress and human health

Rahman, T., Hosen, M. I., Islam, M. M., & Shekhar, H. U. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.327123 · Cited by 514

The Role of Inflammation in the Pathogenesis of Age-related Macular Degeneration

Donoso, L. A., Kim, D. S., Frost, A. T., Callahan, A., & Hageman, G. S. (2006) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2005.12.001 · Cited by 486

Choroidal neovascularization

Grossniklaus, H. E., & Green, W. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.09.042 · Cited by 469

Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD

Kuriyan, A. E., Albini, T. A., Townsend, J. H., Rodriguez, M., Pandya, H. K., Leonard, R. E., Parrott, M. B., Rosenfeld, P. J., Flynn, H. W., & Goldberg, J. L. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1609583 · Cited by 474

Development and pathology of the hyaloid, choroidal and retinal vasculature

Saint‐Geniez, M., & D'Amore, P. A. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041895ms · Cited by 413

Recent developments in age-related macular degeneration: a review

Al-Zamil, W. M., & Yassin, S. A. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s143508 · Cited by 427

Geographic Atrophy

Holz, F. G., Strauss, E. C., Schmitz-Valckenberg, S., & Campagne, M. V. L. (2014) · Ophthalmology · doi:10.1016/j.ophtha.2013.11.023 · Cited by 404

Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration

Mullins, R. F., Johnson, M. N., Faidley, E. A., Skeie, J. M., & Huang, J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6476 · Cited by 394

Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

de Carlo, T. E., Filho, M. A. B., Chin, A. T., Adhi, M., Ferrara, D., Baumal, C. R., Witkin, A. J., Reichel, E., Duker, J. S., & Waheed, N. K. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.01.029 · Cited by 395

Age-Related Macular Degeneration Preferred Practice Pattern®

Flaxel, C. J., Adelman, R. A., Bailey, S. T., Fawzi, A. A., Lim, J. I., Vemulakonda, G. A., & Ying, G. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.09.024 · Cited by 367

Ten-Year Incidence and Progression of Age-Related Maculopathy

Wang, J. J., Rochtchina, E., Lee, A. J., Chia, E., Smith, W. T., Cumming, R. G., & Mitchell, P. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.07.017 · Cited by 320

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS TRADITIONAL MULTIMODAL IMAGING IN ASSESSING THE ACTIVITY OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION

COSCAS, G. J., Lupidi, M., Coscas, F., Cagini, C., & Souied, E. H. (2015) · Retina · doi:10.1097/iae.0000000000000766 · Cited by 311

Transplantation of the RPE in AMD

Binder, S., Stanzel, B. V., Krebs, I., & Glittenberg, C. G. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.02.002 · Cited by 298

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., Varshney, A., Yasuma, R., Fowler, B. J., Baghdasaryan, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4450 · Cited by 290

High-Resolution Spectral Domain-OCT Imaging in Geographic Atrophy Associated with Age-Related Macular Degeneration

Fleckenstein, M., Issa, P. C., Helb, H. –., Schmitz-Valckenberg, S., Finger, R. P., Scholl, H. P. N., Loeffler, K. U., & Holz, F. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1967 · Cited by 283

Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography

Keane, P. A., Patel, P. J., Liakopoulos, S., Heussen, F. M., Sadda, S. R., & Tufail, A. (2012) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.01.006 · Cited by 291

Dietary ω-3 Fatty Acid and Fish Intake in the Primary Prevention of Age-Related Macular Degeneration: A Systematic Review and Meta-analysis

Chong, E. W.-T. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.6.826 · Cited by 279

Progression of Intermediate Age-related Macular Degeneration with Proliferation and Inner Retinal Migration of Hyperreflective Foci

Christenbury, J. G., Folgar, F. A., O’Connell, R. V., Chiu, S. J., Farsiu, S., & Toth, C. A. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2012.10.018 · Cited by 279

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

Bhutto, I. A., McLeod, D. S., Hasegawa, T., Kim, S. Y., Merges, C., Tong, P., & Lutty, G. A. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.05.007 · Cited by 275

Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success

Jacobson, S. G., Alemán, T. S., Cideciyan, A. V., Sumaroka, A., Schwartz, S., Windsor, E. A. M., Traboulsi, E. I., Héon, E., Pittler, S. J., Milam, A. H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500646102 · Cited by 276

Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration

Ng, E. W. M., & Adamis, A. P. (2005) · Canadian Journal of Ophthalmology · doi:10.1016/s0008-4182(05)80078-x · Cited by 275

CCR3 is a target for age-related macular degeneration diagnosis and therapy

Takeda, A., Baffi, J. Z., Kleinman, M. E., Cho, W. G., Nozaki, M., Yamada, K., Kaneko, H., Albuquerque, R. J. C., Dridi, S., Saito, K., et al. (2009) · Nature · doi:10.1038/nature08151 · Cited by 263

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

Wooff, Y., Man, S. M., Aggio‐Bruce, R., Natoli, R., & Fernando, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01618 · Cited by 250

Drug delivery systems for vitreoretinal diseases

Yasukawa, T., Ogura, Y., Tabata, Y., Kimura, H., Wiedemann, P., & Honda, Y. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.02.003 · Cited by 232

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Fowler, B. J., Gelfand, B. D., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., Amarnath, S., Fowler, D. H., Radwan, M., Young, M. T., et al. (2014) · Science · doi:10.1126/science.1261754 · Cited by 225

Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration

Yang, Z., Stratton, C., Francis, P. J., Kleinman, M. E., Tan, P. L., Gibbs, D., Tong, Z., Chen, H., Constantine, R., Yang, X., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802437 · Cited by 222

The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration

Tuo, J., Smith, B. C., Bojanowski, C. M., Meleth, A. D., Gery, I., Csaky, K. G., Chew, E. Y., & Chan, C.-C. (2004) · The FASEB Journal · doi:10.1096/fj.04-1862fje · Cited by 215

αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells

Sreekumar, P. G., Kannan, R., Kitamura, M., Spee, C. K., Barrón, E., Ryan, S. J., & Hinton, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012578 · Cited by 207

Stem cell based therapies for age-related macular degeneration: The promises and the challenges

Nazari, H. K., Zhang, L., Zhu, D., Chader, G. J., Falabella, P., Stefanini, F. R., Rowland, T. J., Clegg, D., Kashani, A. H., Hinton, D. R., et al. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.06.004 · Cited by 212

Introduction: understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration

Bressler, S. B. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.06.045 · Cited by 205

Ion channels in the RPE

WIMMERS, S., KARL, M., & STRAUSS, O. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.12.002 · Cited by 207

Functional and cortical adaptations to central vision loss

Cheung, S. H., & Legge, G. E. (2005) · Visual Neuroscience · doi:10.1017/s0952523805222071 · Cited by 214

The Drusenlike Phenotype in Aging Ccl2 -Knockout Mice Is Caused by an Accelerated Accumulation of Swollen Autofluorescent Subretinal Macrophages

Luhmann, U. F. O., Robbie, S. J., Munro, P., Barker, S. E., Durán, Y., Luong, V., Fitzke, F. W., Bainbridge, J. W., Ali, R. R., & MacLaren, R. E. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3462 · Cited by 212

Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV

Singh, S. R., GROSSNIKLAUS, H. E., Kang, S. J., Edelhauser, H. F., Ambati, B. K., & Kompella, U. B. (2009) · Gene Therapy · doi:10.1038/gt.2008.185 · Cited by 211

Fundus Autofluorescence and Progression of Age-related Macular Degeneration

Schmitz-Valckenberg, S., Fleckenstein, M., Scholl, H. P. N., & Holz, F. G. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.10.004 · Cited by 203

Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization

Andriessen, E. M., Wilson, A. M., Mawambo, G., Dejda, A., Miloudi, K., Sennlaub, F., & Sapieha, P. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606531 · Cited by 201

Molecular mechanisms of retinal pigment epithelium damage and development of age‐related macular degeneration

Kinnunen, K., Petrovski, G., Moe, M. C., Berta, A., & Kaarniranta, K. (2011) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2011.02179.x · Cited by 202

Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration

Zareparsi, S., Buraczynska, M., Branham, K. E. H., Shah, S., Eng, D., Li, M., Pawar, H., Yashar, B. M., Moroi, S. E., Lichter, P. R., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi154 · Cited by 190

REVIEW: Epidemiology of age-related maculopathy: a review

van Leeuwen, R., Klaver, C. C. W., Vingerling, J. R., Albert Hofman, D., & de Jong, P. T. V. M. (2003) · European Journal of Epidemiology · doi:10.1023/a:1025643303914 · Cited by 190

Age-related eye disease and gender

Zetterberg, M. (2016) · Maturitas · doi:10.1016/j.maturitas.2015.10.005 · Cited by 185

Visual detection, pattern discrimination and visual acuity in 14 strains of mice

Wong, A. A., & Brown, R. E. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00173.x · Cited by 188

Age-Related Macular Degeneration: A High-Resolution Genome Scan for Susceptibility Loci in a Population Enriched for Late-Stage Disease

Abecasis, G. R., Yashar, B. M., Zhao, Y., Ghiasvand, N. M., Zareparsi, S., Branham, K. E. H., Reddick, A. C., Trager, E. H., Yoshida, S., Bahling, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/382786 · Cited by 182

Correlation between the Area of Increased Autofluorescence Surrounding Geographic Atrophy and Disease Progression in Patients with AMD

Schmitz-Valckenberg, S., Bindewald-Wittich, A., Dolar-Szczasny, J., Dreyhaupt, J., Wolf, S., Scholl, H. P. N., & Holz, F. G. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0892 · Cited by 180

The mitochondrial-Derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction

Sreekumar, P. G., Ishikawa, K., Spee, C., Mehta, H. H., Wan, J., Yen, K., Cohen, P., Kannan, R., & Hinton, D. R. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-17053 · Cited by 179

Minimizing projection artifacts for accurate presentation of choroidal neovascularization in OCT micro-angiography

Zhang, A., Zhang, Q., & Wang, R. K. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.004130 · Cited by 173

Documentation of Intraretinal Retinal Pigment Epithelium Migration via High-Speed Ultrahigh-Resolution Optical Coherence Tomography

Ho, J., Witkin, A. J., Liu, J. J., Chen, Y., Fujimoto, J. G., Schuman, J. S., & Duker, J. S. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2010.08.010 · Cited by 171

Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo

Lowe, J. R., Araujo, J., Yang, J., Reich, M., Oldendorp, A., Shiu, V., Quarmby, V. E., Lowman, H. B., Lien, S., Gaudreault, J., et al. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.05.008 · Cited by 170

The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration

Grisanti, S., & Tatar, O. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.002 · Cited by 163

Immunopathological aspects of age-related macular degeneration

Patel, M. M., & Chan, C. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0112-9 · Cited by 167

Anti‐VEGF Aptamer (Pegaptanib) Therapy for Ocular Vascular Diseases

Ng, E. W. M., & Adamis, A. P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1348.062 · Cited by 160

An update on the genetics of age-related macular degeneration

Scholl, H. P. N., Fleckenstein, M., Issa, P. C., Keilhauer, C. N., Holz, F. G., & Weber, B. H. F. (2007) · PubMed Central · doi:10.5283/epub.35844 · Cited by 156

Mfsd2a is a transporter for the essential ω-3 fatty acid docosahexaenoic acid (DHA) in Eye and is important for photoreceptor cell development

Wong, B. H., Chan, J. P., Cazenave-Gassiot, A., Poh, R. W., Foo, J. C., Galam, D. L. A., Ghosh, S., Nguyen, L. N., Barathi, V. A., Yeo, S. W., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.721340 · Cited by 155

Drusen volume development over time and its relevance to the course of age-related macular degeneration

Schlanitz, F. G., Baumann, B., Kundi, M., Sacu, S., Baratsits, M., Scheschy, U., Shahlaee, A., Mittermüller, T. J., Montuoro, A., Roberts, P. K., et al. (2016) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2016-308422 · Cited by 156

Carotenoids and Antioxidants in Age-Related Maculopathy Italian Study

Parisi, V., Tedeschi, M., GALLINARO, G., Varano, M., Saviano, S., & Piermarocchi, S. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2007.05.029 · Cited by 156

Fixation pattern and macular sensitivity in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. A microperimetry study

Midena, E., Radin, P. P., Pilotto, E., Ghirlando, A., Convento, E., & Varano, M. (2004) · Seminars in Ophthalmology · doi:10.1080/08820530490882896 · Cited by 155

Combined Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography Imaging of Reticular Drusen Associated with Age-Related Macular Degeneration

Schmitz-Valckenberg, S., Steinberg, J. S., Fleckenstein, M., Visvalingam, S., Brinkmann, C. K., & Holz, F. G. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2009.10.044 · Cited by 154

Burden and Health Care Resource Utilization in Neovascular Age-Related Macular Degeneration

Soubrane, G. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.9.1249 · Cited by 156

Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age‐related macular degeneration

Nagineni, C. N., Kommineni, V. K., William, A., Detrick, B., & Hooks, J. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22708 · Cited by 158

A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

Anderson, O. A., Finkelstein, A., & Shima, D. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067263 · Cited by 152

Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)

Arjamaa, O., Nikinmaa, M., Salminen, A., & Kaarniranta, K. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.06.002 · Cited by 150

Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in a Large Cohort from a Single Center

Zareparsi, S. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-1253 · Cited by 145

Retinal capillary perfusion: Spatial and temporal heterogeneity

Yu, D., Cringle, S. J., Yu, P. K., Balaratnasingam, C., Mehnert, A., Šarunic, M. V., An, D., & Su, E. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.01.001 · Cited by 149

Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases

Vadlapatla, R. K., Vadlapudi, A. D., & Mitra, A. K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990015 · Cited by 148

Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

Natoli, R., Fernando, N., Madigan, M. C., Chu‐Tan, J. A., Valter, K., Provis, J. M., & Rutar, M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0175-y · Cited by 146

Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation

Colquitt, J. L., Jones, J., Tan, S., Takeda, A., Clegg, A. P., & Price, A. (2008) · Health Technology Assessment · doi:10.3310/hta12160 · Cited by 141

Light induced cytosolic drug delivery from liposomes with gold nanoparticles

Lajunen, T., Viitala, L., Kontturi, L.-S., Laaksonen, T., Liang, H., Vuorimaa, E., Viitala, T., Guével, X. L., Yliperttula, M. L., Murtomäki, L. S., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.028 · Cited by 141

Autologous Transplantation of the Retinal Pigment Epithelium and Choroid in the Treatment of Neovascular Age-Related Macular Degeneration

MacLaren, R. E., Uppal, G., Balaggan, K. S., Tufail, A., Munro, P., Milliken, A. B., Ali, R. R., Rubin, G. S., Aylward, G. W., & da Cruz, L. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2006.06.049 · Cited by 137

Age-related maculopathy – Linking aetiology and pathophysiological changes to the ischaemia hypothesis

Feigl, B. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.11.004 · Cited by 139

TUMOR NECROSIS FACTOR ANTAGONISTS

THEODOSSIADIS, P. G., Markomichelakis, N., & Sfikakis, P. P. (2007) · Retina · doi:10.1097/maj.0b013e3180318fbc · Cited by 136

Mechanism of Inflammation in Age-Related Macular Degeneration

Parmeggiani, F., Romano, M., Costagliola, C., Semeraro, F., Incorvaia, C., D’Angelo, S., Perri, P., Palma, P. D., Nadai, K. D., & Sebastiani, A. (2012) · Mediators of Inflammation · doi:10.1155/2012/546786 · Cited by 140

The effect of aging on the cutaneous microvasculature

Bentov, I., & Reed, M. J. (2015) · Microvascular Research · doi:10.1016/j.mvr.2015.04.004 · Cited by 148

CHARACTERIZING THE EFFECT OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY ON TREATMENT-NAIVE CHOROIDAL NEOVASCULARIZATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Muakkassa, N. W., Chin, A. T., de Carlo, T. E., Klein, K. A., Baumal, C. R., Witkin, A. J., Duker, J. S., & Waheed, N. K. (2015) · Retina · doi:10.1097/iae.0000000000000836 · Cited by 132

Intraocular sustained drug delivery using implantable polymeric devices

Yasukawa, T., OGURA, Y., Sakurai, E., Tabata, Y., & KIMURA, H. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.005 · Cited by 132

Projection Artifact Removal Improves Visualization and Quantitation of Macular Neovascularization Imaged by Optical Coherence Tomography Angiography

Zhang, Q., Zhang, A., Lee, C. S., Lee, A., Rezaei, K. A., Roisman, L., Miller, A., Zheng, F., Gregori, G., Durbin, M. K., et al. (2016) · Ophthalmology Retina · doi:10.1016/j.oret.2016.08.005 · Cited by 131

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in Macular degeneration

Chen, P. M., Gombart, Z. J., & Chen, J. W. (2011) · Cell & Bioscience · doi:10.1186/2045-3701-1-10 · Cited by 122

High concentration of zinc in sub-retinal pigment epithelial deposits

Lengyel, I., Flinn, J. M., Pető, T., Linkous, D. H., Cano, K., Bird, A. C., Lanzirotti, A., Frederickson, C. J., & van Kuijk, F. J. G. M. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2006.12.015 · Cited by 128

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

Bhutto, I. A., Baba, T., Merges, C., Juriasinghani, V., McLeod, D. S., & Lutty, G. A. (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.199216 · Cited by 126

Economic Burden of Bilateral Neovascular Age-Related Macular Degeneration: Multi-Country Observational Study

Cruess, A. F., Zlateva, G., Xu, X., Soubrane, G., Pauleikhoff, D., Lotery, A., Mones, J., Buggage, R., Schaefer, C., Knight, T., et al. (2008) · PharmacoEconomics · doi:10.2165/00019053-200826010-00006 · Cited by 126

Burden of illness, visual impairment and health resource utilisation of patients with neovascular age-related macular degeneration: results from the UK cohort of a five-country cross-sectional study

Lotery, A., Xu, X., Zlatava, G., & Loftus, J. (2007) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.116939 · Cited by 124

The role of advanced glycation end products in retinal ageing and disease

Glenn, J. V., & Stitt, A. W. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.016 · Cited by 127

The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration

Gorusupudi, A., Nelson, K., & Bernstein, P. S. (2017) · Advances in Nutrition · doi:10.3945/an.116.013177 · Cited by 130

New research progress on the epidemiology of age-related macular degeneration

Wu, M., Zheng, Z., & Zhou, X. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3980/j.issn.1672-5123.2015.2.10 · Cited by 2

Age-Related Macular Degeneration: Current Concepts of Pathogenesis and Risk Factors

Schütt, F., & Holz, F. G. (2001) · Medical radiology · doi:10.1007/978-3-642-56439-0_1 · Cited by 2

Age-related macular degeneration

Fleckenstein, M., Keenan, T. D. L., Guymer, R. H., Chakravarthy, U., Schmitz-Valckenberg, S., Klaver, C. C. W., Wong, W. T., & Chew, E. Y. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00265-2 · Cited by 1,093

Age-related Macular Degeneration: Genetic and Environmental Factors of Disease

Chen, Y., Bedell, M., & Zhang, K. (2010) · Molecular Interventions · doi:10.1124/mi.10.5.4 · Cited by 143

Genetics and Genomics in Clinical Ophthalmology, III: Age-Related Macular Degeneration

Kleinman, M. E., & Ambati, J. (2014) · Oxford University Press eBooks · doi:10.1093/med/9780199896028.003.0042