CoChat
Sign Up
Cited by 39

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells

Riganti, Chiara, Aldieri, Elisabetta, Bergandi, Loredana, Tomatis, Maura, Fenoglio, Ivana, Costamagna, Costanzo, Fubini, Bice, Bosia, Amalia, Ghigo, Dario·2003·Toxicology and Applied Pharmacology
DOI 10.1016/s0041-008x(03)00339-9
Open this paper in CoChat — free account

Abstract

The mechanism by which asbestos fibers are fibrogenic and tumorigenic is still matter of debate. The higher pathogenicity of longer fibers has been traditionally associated with their slower clearance in respiratory airways. However, short amosite fibers, obtained by grinding longer ones, exhibited a lower potential to damage nude DNA and a lower in vitro cytotoxicity. We have thus revisited the two sets of long and short fibers in order to compare their surface properties to their activity in cell systems. In this study we report that, in human lung epithelial cells A549, long amosite fibers, more effectively than the short ones, initiate free radical reactions, inhibit the glucose 6-phosphate dehydrogenase activity and the pentose phosphate pathway, decrease the intracellular level of reduced glutathione, and increase the generation of thiobarbituric acid reactive substances and the leakage of lactate dehydrogenase in the extracellular medium. These results suggest that the shortening of fibers by prolonged milling affects not only their biopersistence, but also their surface properties, hence their interaction with cellular metabolism. Our data provide also a mechanism by which asbestos fibers inhibit the pentose phosphate pathway, i.e., via the oxidative inhibition of glucose 6-phosphate dehydrogenase, which is prevented by reduced glutathione.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0041-008x(03)00339-9

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 6 references

Research works printed but not linked: 19

  1. Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 · DOI
  2. Davis, 1986, The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection, Br. J. Exp. Pathol., 67, 415
  3. Donaldson, 1989, Inflammation generating potential of long and short fiber amosite asbestos samples, Br. J. Ind. Med., 46, 271
  4. Donaldson, 1992, Asbestos-stimulated tumor-necrosis-factor release from alveolar macrophages depends on fiber length and opsonization, J. Pathol., 168, 243, 10.1002/path.1711680214 · DOI
  5. Donaldson, 1993, Asbestos fiber length-dependent detachment injury to alveolar epithelial-cells in vitro, Int. J. Exp. Pathol., 74, 243
  6. Gaetani, 1974, Intracellular restraint, Proc. Natl. Acad. Sci. USA, 71, 3584, 10.1073/pnas.71.9.3584 · DOI
  7. Gilmour, 1995, Detection of surface free radical activity of respirable industrial fibres using supercoiled phi X174 RF1 plasmid DNA, Carcinogenesis, 16, 2973, 10.1093/carcin/16.12.2973 · DOI
  8. Golladay, 1997, Efflux of reduced glutathione after exposure of human lung epithelial cells to crocidolite asbestos, Environ. Health Perspect., 105, 1273, 10.1289/ehp.97105s51273 · DOI
  9. Hill, 1995, Differential release of superoxide anion by macrophages treated with long and short amosite asbestos is a consequence of differential affinity for opsonin, Occup. Environ. Med., 52, 92, 10.1136/oem.52.2.92 · DOI
  10. Hodgson, 2000, The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure, Ann. Occup. Hyg., 44, 565, 10.1093/annhyg/44.8.565 · DOI · Paper page
  11. Kinnula, 1999, Oxidant and antioxidant mechanisms of lung disease caused by asbestos fibres, Eur. Respir. J., 14, 706, 10.1034/j.1399-3003.1999.14c35.x · DOI
  12. Kinnula, 1994, Cytotoxicity of oxidants and asbestos fibers in cultured human mesothelial cells, Free Radical Biol. Med., 16, 169, 10.1016/0891-5849(94)90140-6 · DOI
  13. Luzzatto, 1968, Enzymic properties of different types of human erythrocyte glucose 6-phosphate dehydrogenase, with characterization of two new genetic variants, J. Clin. Invest., 47, 1833, 10.1172/JCI105873 · DOI
  14. Park, 1998, Regulation of nitric oxide synthase induction by iron and glutathione in asbestos-treated human lung epithelial cells, Arch. Biochem. Biophys., 360, 47, 10.1006/abbi.1998.0950 · DOI
  15. Riganti, 2002, Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cells, Free Radical Biol. Med., 32, 938, 10.1016/S0891-5849(02)00800-6 · DOI
  16. Robledo, 1999, Cellular and molecular mechanisms of asbestos-induced fibrosis, J. Cell. Physiol., 180, 158, 10.1002/(SICI)1097-4652(199908)180:2<158::AID-JCP3>3.0.CO;2-R · DOI
  17. Stanton, 1972, Mechanisms of mesothelioma induction with asbestos and fibrous glass, J. Natl. Cancer Inst., 48, 797
  18. Vandeputte, 1994, A microtiter assay for total glutathione and glutathione disulfide contents in cultured/isolated cells, Cell Biol. Toxicol., 10, 415, 10.1007/BF00755791 · DOI
  19. Yano, 1988, Mineral fiber-induced malondialdehyde formation and effects of oxidant scavengers in phagocytic cells, Int. Arch. Occup. Environ. Health, 61, 19, 10.1007/BF00381603 · DOI

Cited by

Sorted by citations

See all 39

Metadata

Authors
Riganti, C., Aldieri, E., Bergandi, L., Tomatis, M., Fenoglio, I., Costamagna, C., Fubini, B., Bosia, A., & Ghigo, D.
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2003-11
Volume
193
Issue
1
Pages
106-115
ISSN
0041-008X
DOI
10.1016/s0041-008x(03)00339-9
Cited by
39
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells. https://app.cochat.ai/papers/10.1016/s0041-008x(03)00339-9
The paper
Riganti, C., Aldieri, E., Bergandi, L., Tomatis, M., Fenoglio, I., Costamagna, C., Fubini, B., Bosia, A., & Ghigo, D. (2003). Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells. Toxicology and Applied Pharmacology. https://doi.org/10.1016/s0041-008x(03)00339-9