Chemical differences between long and short amosite asbestos: differences in oxidation state and coordination sites of iron, detected by infrared spectroscopy.
Open accessAbstract
OBJECTIVES: Short fibres of amosite asbestos (SFA), obtained by ball milling of long fibres (LFA), have been shown to be less pathogenic than long fibres. Accumulating evidence suggests an important role for differences in surface chemistry between fibres. Iron has been implicated in the pathogenesis of asbestos fibres. In this study infrared (IR) spectroscopy was used to compare LFA and SFA in terms of the coordination and oxidation state of iron at the three cation sites (M1, M3, M1). METHODS: Infrared was used to examine LFA ad SFA, when dry and when hydrated in the presence and absence of the chelators desferroxamine and ferrozine. With appropriate software the proportions of iron and its oxidation states in the overlapping peaks were resolved and assigned, and the three coordination sites were identified. Data were obtained from 10 samples of both lengths of fibre for each of the four treatments. Iron release was also monitored. RESULTS: Iron was significantly more oxidised in LFA than SFA. Further oxidation of the dry fibres with water, ferrozine, or desferroxamine tended to abolish these differences. There were also significant differences between the proportions of iron held in the different coordination sites of the fibres. For LFA, a higher proportion of its iron was held in the cation sites coordinating less with iron and more with Mg. Interestingly, the sites coordinating single irons were significantly more oxidised than multiple sites. The single iron sites were more oxidised in LFA than SFA and were more readily oxidised by the treatments. CONCLUSIONS: Important chemical differences between LFA and SFA were found. There seemed to be some mobility of iron near the surface. Based on these data it is speculated that the 1 iron surface site may be important in pathogenesis.
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Iron is implied in free radical generation from asbestos, but the effects elicited are unrelated to total iron content, suggesting the presence of specific iron active sites.
“Iron is implied in free radical generation from asbestos but the effects elicited are unrelated to total iron content, suggesting the presence of specific iron active sites.[21][22][23][24]”
From Free radical generation in the toxicity of inhaled mineral particles: the role of iron speciation at the surface of asbestos and silica (2001) · cites this paper as [23]
The introductory passage (page unavailable) links iron to free-radical generation and reports greater free-radical activity in long than short amosite fibres. The Discussion (page unavailable) speculates that a particular iron coordination site may be important in damaging processes. The paper does not establish the broader claim that the effects are unrelated to total iron content. (LLM, conf=0.82)
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Cites
The role of free radicals in asbestos-induced diseases
Kamp, D. W., Graceffa, P., Pryor, W. A., & Weitzman, S. A. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90117-y · Cited by 428 · see citing works
Davis, J. M., Addison, J., Bolton, R., Donaldson, K., Jones, A. D., & Smith, T. A. (1986) · PubMed Central · Cited by 256 · see citing works
Self-citationNonequilibrium Roughening of Interfaces in Crystals under Shear: Application to Ball Milling
Bellon, P., & Averback, R. S. (1995) · Physical Review Letters · doi:10.1103/physrevlett.74.1819 · Cited by 254 · see citing works
Erionite exposure and mesotheliomas in rats
Wagner, J. C., Skidmore, J., Hill, R. J., & Griffiths, D. M. (1985) · British Journal of Cancer · doi:10.1038/bjc.1985.108 · Cited by 228 · see citing works
Free Radical Generation at the Solid/Liquid Interface in Iron Containing Minerals
Fubini, B., Mollo, L., & Giamello, E. (1995) · Free Radical Research · doi:10.3109/10715769509065280 · Cited by 177 · see citing works
Role of iron in the reactivity of mineral fibers
Fubini, B., & Mollo, L. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03531-1 · Cited by 125 · see citing works
Inflammation generating potential of long and short fibre amosite asbestos samples.
Donaldson, K., Brown, G. M., Brown, D. M., Bolton, R., & Davis, J. M. (1989) · Occupational and Environmental Medicine · doi:10.1136/oem.46.4.271 · Cited by 124 · see citing works
Self-citationMonchaux, G., Bignon, J., Jaurand, M., Lafuma, J., Sebastien, P., Masse, R. S., Hirsch, A., & Goni, J. (1981) · Carcinogenesis · doi:10.1093/carcin/2.3.229 · Cited by 107 · see citing works
Donaldson, K., Li, X. Y., Dogra, S., Miller, B. G., & Brown, G. M. (1992) · The Journal of Pathology · doi:10.1002/path.1711680214 · Cited by 67 · see citing works
Self-citationGilmour, P. S., Beswick, P. H., Brown, D. M., & Donaldson, K. (1995) · Carcinogenesis · doi:10.1093/carcin/16.12.2973 · Cited by 62 · see citing works
Self-citationHealthy environments for healthy people: bioremediation today and tomorrow.
Bonaventura, C., & Johnson, F. M. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s15 · Cited by 55 · see citing works
Hill, I. M., Beswick, P. H., & Donaldson, K. (1995) · Occupational and Environmental Medicine · doi:10.1136/oem.52.2.92 · Cited by 55 · see citing works
Self-citationWylie, A. G., Skinner, H. C. W., Marsh, J. P., Snyder, H., Garzione, C. N., Hodkinson, D. G., Winters, R., & Mossman, B. T. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8276 · Cited by 37 · see citing works
Chemical characterization and reactivity of iron chelator-treated amphibole asbestos.
Gold, J., Amandusson, H., Krozer, A., Kasemo, B., Ericsson, T., Zanetti, G., & Fubini, B. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51021 · Cited by 35 · see citing works
DNA strand breaks following in vitro exposure to asbestos increase with surface-complexed [Fe3+]
Ghio, A. J., Kennedy, T. P., Stonehuerner, J. G., Crumbliss, A. L., & Hoidal, J. R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1202 · Cited by 33 · see citing works
Scheule, R. K., & Holian, A. (1989) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/1.4.313 · Cited by 31 · see citing works
Brown, G. M., Cowie, H. A., Davis, J. M., & Donaldson, K. (1986) · Carcinogenesis · doi:10.1093/carcin/7.12.1971 · Cited by 28 · see citing works
Self-citationDonaldson, K., Miller, B. G., Sara, E., Slight, J., & Brown, R. C. (1993) · Europe PMC (PubMed Central) · Cited by 28 · see citing works
Self-citationHill, I. M., Beswick, P. H., & Donaldson, K. (1996) · Experimental Lung Research · doi:10.3109/01902149609050843 · Cited by 19 · see citing works
Self-citationCharacteristics of asbestos minerals. Structural aspects and infrared spectra
Luys, M.-J., Roy, G. D., Vansant, E. F., & Adams, F. C. (1982) · Journal of the Chemical Society Faraday Transactions 1 Physical Chemistry in Condensed Phases · doi:10.1039/f19827803561 · Cited by 18 · see citing works
Shen, Z., Parker, V. D., & Aust, A. E. (1995) · Analytical Chemistry · doi:10.1021/ac00098a013 · Cited by 14 · see citing works
Brown, D. M., Roberts, N., & Donaldson, K. (1997) · Toxicology in Vitro · doi:10.1016/s0887-2333(97)00093-3 · Cited by 14 · see citing works
Self-citationDumitru-Stănescu, R., Mandravel, C., & Bercu, C. (1994) · The Analyst · doi:10.1039/an9941900689 · Cited by 13 · see citing works
Chemical Characterization and Reactivity of Iron Chelator-Treated Amphibole Asbestos
Gold, J., Amandusson, H., Krozer, A., Kasemo, B., Ericsson, T., Zanetti, G., & Fubini, B. (1997) · Environmental Health Perspectives · doi:10.2307/3433503 · Cited by 8 · see citing works
Donaldson, K., Golyasnya, N., & Davis, J. M. (1994) · Springer eBooks · doi:10.1007/978-3-642-79041-6_20 · Cited by 4 · see citing works
Self-citationValerio, F., & Balducci, D. (1989) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [1]1. pigs. In: Walton WH, ed. Inhaled Particles IV. Oxford: Per- gamon Press, 1977:455-74.
- [10]10. Hill IM, Beswick PH, Donaldson K. Enhancement of the macrophage oxidative burst by IgG coating of respirable fibres. Fibre-specific diVerences between asbestos and man-made fibres. Exp Lung Res 1996;22:133-48.
- [12]12. Luys M-J, De Roy G, Vansant EF, et al. Characteristics of asbestos minerals. Journal of the Chemical Society Faraday Transactions I 1982;78:3561-71.
- [19]19. Dumitru-Stanescu R, Mandravel C, Bercu C. Infrared and NMR studies of some surface properties of asbestos- albumin interactions. Analyst 1994;119:689-91.
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Self-citationBoyles, M. S. P., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., Smail, F., Smith, P. J. W., Proudfoot, L., Windle, A. H., et al. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.06.012 · Cited by 182 · see citing works
Schinwald, A., Murphy, F. A., Prina-Mello, A., Poland, C. A., Byrne, F., Movia, D., Glass, J. R., Dickerson, J. C., Schultz, D. A., Jeffree, C. E., et al. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs171 · Cited by 181 · see citing works
Self-citationThe Medical Geochemistry of Dusts, Soils, and Other Earth Materials
Plumlee, G. S., & Ziegler, T. L. (2004) · Elsevier eBooks · doi:10.1016/b0-08-043751-6/09050-2 · Cited by 101 · see citing works
Fenoglio, I., Prandi, L., Tomatis, M., & Fubini, B. (2001) · Redox Report · doi:10.1179/135100001101536382 · Cited by 84 · see citing works
Tomatis, M., Turci, F., Ceschino, R., Riganti, C., Gazzano, E., Martra, G., Ghigo, D., & Fubini, B. (2010) · Inhalation Toxicology · doi:10.3109/08958378.2010.504243 · Cited by 53 · see citing works
Riganti, C., Aldieri, E., Bergandi, L., Tomatis, M., Fenoglio, I., Costamagna, C., Fubini, B., Bosìa, A., & Ghigo, D. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00339-9 · Cited by 46 · see citing works
Redox state and mobility of iron at the asbestos surface: a voltammetric approach
Prandi, L., Bodoardo, S., Penazzi, N., & Fubini, B. (2001) · Journal of Materials Chemistry · doi:10.1039/b005714m · Cited by 18 · see citing works
Ribak, J., & Ribak, G. (2007) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2007.10.002 · Cited by 15 · see citing works
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Poland, C. A., Duffin, R., & Donaldson, K. (2009) · Wiley eBooks · doi:10.1002/9780470747803.ch4 · Cited by 11 · see citing works
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Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
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- Authors
- Graham, A., Higinbotham, J., Allan, D., Donaldson, K., & Beswick, P. H.
- Affiliations
- Edinburgh Napier University (GB)
- Venue
- Occupational and Environmental Medicine
- Publisher
- BMJ
- Published
- 1999-09
- Volume
- 56
- Issue
- 9
- Pages
- 606-611
- ISSN
- 0007-1072 (ISSN-L)
- 1351-0711
- 1470-7926
- PMC
- PMC1757792
- OpenAlex
- W2152483402
- Semantic Scholar
- a9314a35da40048b02e230ddfbf647e2210d3dde
- Cited by
- 18
- References
- 26
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Occupational and Environmental Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Social Sciences › Health › Occupational Health and Global Justice
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- amosite asbestos, iron oxidation state, fiber surface chemistry, ferrozine, iron release, ball milling
- MeSH terms
- Iron, Oxidation-Reduction, Spectroscopy, Fourier Transform Infrared, Asbestos, Amosite
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