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The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-γ
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“This function was demonstrated to occur through HPV-16 E5’s inhibition of endosome acidification, which prevents the breakdown of invariant chain and blocks formation of peptide-loaded MHC class II dimers, leading to decreased surface expression of MHC class II molecules, thus disrupting antigen presentation to effector T-cells [348].”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [348]
In the citing paper
“In addition, maturation of MHC class II molecules in human foreskin keratinocytes upon interferon gamma treatment has also been suggested to be perturbed by expression of HPV-16 E5.”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [348]
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Cited by
Molecular biology of human papillomavirus infection and cervical cancer
Doorbar, J. (2006) · Clinical Science · doi:10.1042/cs20050369 · Cited by 1,072
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Zhang, B., Li, P., Wang, E., Brahmi, Z., Dunn, K. W., Blum, J. S., & Roman, A.
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 310
- Issue
- 1
- Pages
- 100-108
- ISSN
- 0042-6822
- Cited by
- 108
- References
- 0
- Language
- en
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