Behavioral visual responses of wild-type and hypopigmented zebrafish
Open accessAbstract
Zebrafish possess three classes of chromatophores that include iridophores, melanophores, and xanthophores. Mutations that lack one or two classes of chromatophores have been isolated or genetically constructed. Using a behavioral assay based on visually mediated escape responses, we measured the visual response of fully and partially pigmented zebrafish. In zebrafish that lack iridophores (roy mutants), the behavioral visual responses were similar to those of wild-type animals except at low contrast stimulation. In the absence of melanophores (albino mutants) or both melanophores and iridophores (ruby mutants), the behavioral visual responses were normal under moderate illumination but reduced when tested under dim or bright conditions or under low contrast stimulation. Together, the data suggest that screening pigments in the retina play a role in the regulation of behavioral visual responses and are necessary for avoiding "scatter" under bright light conditions.
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A previous study reported that adult zebrafish mutants with hypopigmented eyes show deficits in performing visual escape assays under defined luminance conditions.
“A previous study has reported that adult zebrafish mutants with hypopigmented eyes show deficits in performing visual escape assays under defined luminance conditions34.”
From A crystal-clear zebrafish for in vivo imaging (2016) · cites this paper as [34]
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D’Agati, G., Beltre, R., Sessa, A., Burger, A., Zhou, Y., Mosimann, C., & White, R. M. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.07.017 · Cited by 87 · see citing works
- Authors
- Ren, J. Q., McCarthy, W. R., Zhang, H., Adolph, A. R., & Li, L.
- Affiliations
- University of Kentucky (US)
- Harvard University (US)
- Shandong University (CN)
- Corresponding author
- Li, Lei
- Venue
- Vision Research
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 42
- Issue
- 3
- Pages
- 293-299
- ISSN
- 0042-6989 (ISSN-L)
- OpenAlex
- W1991229993
- Cited by
- 87
- References
- 2
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Vision Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Kentucky
- National Institutes of Health
- National Eye Institute (R01EY013680)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- zebrafish, chromatophores, iridophores, melanophores, xanthophores, hypopigmentation, visual responses, albino mutants, light scattering, contrast sensitivity, retina
- MeSH terms
- Animals, Chromatophores, Dark Adaptation, Escape Reaction, Lighting, Melanophores, Retina, Visual Perception, Zebrafish, Contrast Sensitivity, Albinism, Ocular
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