Chemistry of Visual Adaptation in the Rat
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In contrast to invertebrates, vertebrates evolved a relatively complex sequence of enzymatic reactions to facilitate thermodynamically unfavorable isomerization of retinoid independently of light.
“In contrast to invertebrates, in which isomerized visual chromophore does not leave the binding pocket and can be re-isomerized back to 11-cis configuration in situ [82,83], vertebrates evolved a relatively complex sequence of enzymatic reactions to facilitate thermodynamically unfavorable isomerization of retinoid independently of light [3,84].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [84]
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- Authors
- DOWLING, J. E.
- Affiliations
- Harvard University (US)
- Corresponding author
- DOWLING, JOHN E.
- ORCID
- DOWLING, JOHN E.
- Venue
- Nature
- Published
- 1960-10
- Volume
- 188
- Issue
- 4745
- Pages
- 114-118
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1992632065
- Cited by
- 543
- References
- 21
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- visual adaptation, rhodopsin, retinal pigment epithelium, phototransduction, rod photoreceptors, rat retina, light adaptation
- MeSH terms
- Acclimatization, Adaptation, Ocular, Adaptation, Physiological, Animals, Eye, Head, Rats
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