An investigation into the nature of giant cells in cardiac and skeletal muscle
Abstract
In an immunohistochemical study of six cases of giant cell myocarditis, the typical giant cells have been shown to express up to four different macrophage-associated antigens, but not desmin, the intermediate filament protein characteristic of muscle cells. These results support the view that the giant cells have a macrophage rather than a myogenic origin. In contrast, the giant cells found in regenerating skeletal muscle have the immunophenotype of muscle cells and not of macrophages supporting their muscle origin.
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In giant cell myocarditis and cardiac sarcoidosis, macrophages are a significant contributor to the formation of multinucleated giant cells or granulomas.
“In well-known forms of autoimmune myocarditis such as giant cell myocarditis and cardiac sarcoidosis, macrophages have been identified as a significant contributor to the formation of multinucleated giant cells or granulomas”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [112]
Giant cell myocarditis shows myocardial infiltration of multinucleated giant cells along with lymphocytes and eosinophils.
“Histopathologic observations reveal myocardial infiltration of multinucleated giant cells along with lymphocytes and eosinophils in this condition.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [112]
Macrophages play a pivotal role in giant cell myocarditis.
“Macrophages also play a pivotal role in giant cell myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [112]
Multinucleated giant cells stain positive for macrophage or other myeloid cell markers in clinical settings and animal models of giant cell myocarditis.
“multinucleated giant cells stained positive for macrophage or other myeloid cell markers in both clinical settings and animal models.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [112]
Cites
Giant cell myocarditis: evidence for the macrophage origin of the giant cells.
Theaker, J. M., Gatter, K. C., Heryet, A., Evans, D. J., & McGee, J. O. (1985) · Journal of Clinical Pathology · doi:10.1136/jcp.38.2.160 · Cited by 39 · see citing works
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
- Authors
- Theaker, J. M., Gatter, K. C., Brown, D. C., Heryet, A., & Davies, M. J.
- Affiliations
- St George's, University of London (GB)
- Corresponding author
- Theaker, J.M.
- ORCID
- Davies, M.J.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 1988-08
- Volume
- 19
- Issue
- 8
- Pages
- 974-979
- ISSN
- 0046-8177 (ISSN-L)
- OpenAlex
- W2040435998
- Cited by
- 23
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2018: 1 · 2014: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Keywords
- giant cells, giant cell myocarditis, desmin, skeletal muscle regeneration, macrophage origin, myocardium, immunophenotype
- MeSH terms
- Adult, Antibodies, Monoclonal, Female, Humans, Immunohistochemistry, Male, Middle Aged, Muscles, Myocarditis, Myocardium
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