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Cited by 39Viral Infections and Immunology ResearchVasculitis and related conditionsCardiac Fibrosis and Remodeling

Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

Open access
Theaker, J M, Gatter, K C, Heryet, A, Evans, D J, McGee, J O·1985·Journal of Clinical Pathology
DOI 10.1136/jcp.38.2.160PMC PMC499096
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Abstract

In order to elucidate the origin of giant cells in giant cell myocarditis a case has been studied immunohistologically using monoclonal antibodies against a variety of antigens, including those associated with muscle and macrophages. The results strongly suggest that the giant cells are derived from macrophages rather than the muscle cells.

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Integrity signals

Registry

Crossref · 10.1136/jcp.38.2.160

Cites

13 of 13 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • In giant cell myocarditis and cardiac sarcoidosis, macrophages are a significant contributor to the formation of multinucleated giant cells or granulomas.

    “In well-known forms of autoimmune myocarditis such as giant cell myocarditis and cardiac sarcoidosis, macrophages have been identified as a significant contributor to the formation of multinucleated giant cells or granulomas”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [111]

    The Abstract (p. 160) and Discussion report evidence that giant cells in the studied case of giant cell myocarditis were probably derived from macrophages. The paper does not establish this for cardiac sarcoidosis or granuloma formation; Material and methods states that granuloma formation was not observed in this case. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Multinucleated giant cells stain positive for macrophage or other myeloid cell markers in clinical settings and animal models of giant cell myocarditis.

    “multinucleated giant cells stained positive for macrophage or other myeloid cell markers in both clinical settings and animal models.”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [111]

    The Immunohistology results (p. 161) report that giant cells in a human case of giant cell myocarditis stained with two antibodies reactive to macrophages. The paper studied one clinical case; it does not report staining in animal models, so that part of the claim is unsupported. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Macrophages play a pivotal role in giant cell myocarditis.

    “Macrophages also play a pivotal role in giant cell myocarditis”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [111]

    The Discussion reports that the characteristic giant cells in the studied case probably derive from macrophages, supporting a role for macrophages. It cautions that other cases may differ and their giant cells may be myogenic, so this single-case finding does not establish a pivotal role across giant cell myocarditis generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Giant cell myocarditis shows myocardial infiltration of multinucleated giant cells along with lymphocytes and eosinophils.

    “Histopathologic observations reveal myocardial infiltration of multinucleated giant cells along with lymphocytes and eosinophils in this condition.”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [111]

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Cites

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Research works printed but not linked: 2

  1. Bliss E, Naiem M, Burns J, Bell K, McGee JO' D, Quantitation of macrophages in human breast cancer using monoclonal antibody (EBMII) to human macrophages. J Pathol 1984; 143: A6.
  2. Pulford KAF, Knight PM, Gatter KC, Mason DY. Immunocytochemical characteristics of monoclonal antileucocyte antibodies. In: Bernard A, Boumsell L, Dausset J, Milstein C, Schlossman SF, eds. Leucocyte typing. New York: Springer-Verlag, 1983:453-65.

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Related

Authors
Theaker, J. M., Gatter, K. C., Heryet, A., Evans, D. J., & McGee, J. O.
Affiliations
  • John Radcliffe Hospital (GB)
  • University of Oxford (GB)
Venue
Journal of Clinical Pathology
Publisher
BMJ
Published
1985-02
Volume
38
Issue
2
Pages
160-164
ISSN
  • 0021-9746 (ISSN-L)
  • 1472-4146
DOI
10.1136/jcp.38.2.160
PMC
PMC499096
OpenAlex
W2079029118
Cited by
39
References
13
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2019: 1 · 2018: 2 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
3.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Pathology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
giant cell myocarditis, giant cells, macrophages, macrophage origin, cell of origin, monoclonal antibodies, immunohistochemistry, myocardium, muscle cells
MeSH terms
Adult, Antibodies, Monoclonal, Female, Humans, Macrophages, Myocarditis, Myocardium

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