Cited by 240Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceNuclear Structure and Function

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Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing

Goto, Makoto·1997·Mechanisms of Ageing and Development

DOI 10.1016/s0047-6374(97)00111-5

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Abstract

Normal human ageing is a complicated biological phenomenon. 'Werner's syndrome (WS)', caused by mutations of RecQ type DNA helicase, has been recognized as a top ranking 'segmental' progeroid syndrome. Patients with WS show a wide variety of clinical and biological manifestations in the four major self-assembly body systems (nervous, immune, connective tissue and endocrine-metabolic systems) similar to normal ageing at an early stage of their life, followed by death at an average age of 46. The sequential appearance of clinical and biological deterioration of the body systems observed in WS suggested that the disorder is more than a segmental progeroid syndrome, analysis of which may shed new light on the question 'Why and how we age?'

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Authors: Goto, M.
Affiliations: Tokyo Metropolitan Ohtsuka Hospital (JP)
Corresponding author: Goto, Makoto
ORCID: Goto, Makoto
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 1997-12
Volume: 98
Issue: 3
Pages: 239-254
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/s0047-6374(97)00111-5
OpenAlex: W1979664563
Cited by: 240
References: 35
Citations by year: 2026: 1 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 9 · 2013: 17 · 2012: 7
FWCI: 3.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: Werner syndrome, progeroid syndromes, aging, premature aging
MeSH terms: Aging, Connective Tissue Diseases, Demography, DNA Helicases, Endocrine System Diseases, Female, Genes, Recessive, Humans, Immune System, Male, Metabolic Diseases, Nervous System, Reference Values, Werner Syndrome

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Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing

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