The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Occurrence of antibiotics in the aquatic environment
Abstract
The recent monitoring of drug residues in the aquatic environment has gained much interest as many pharmaceutical compounds can frequently be found in sewage treatment plant (STP) effluents and river water at concentrations up to several microgram/l. This article describes the analysis of various water samples for 18 antibiotic substances, from the classes of macrolid antibiotics, sulfonamides, penicillins and tetracyclines. Samples were preconcentrated via lyophilization and quantified using HPLC-electrospray-tandem-mass spectrometry. The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazole with concentrations up to 6 micrograms/l. Neither tetracyclines nor penicillins could be detected at concentration levels above 50 and 20 ng/l, respectively. From the large number of ground water samples that were taken from agricultural areas in Germany, no contamination by antibiotics was detected except for two sites. This indicates that intake from veterinary applications to the aquatic environment is of minor importance.
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Cites
Occurrence of drugs in German sewage treatment plants and rivers
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Cited by
Sorted by citations
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es011055j · Cited by 7,953
Pharmaceuticals and Personal Care Products in the Environment: Agents of Subtle Change?
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Antibiotics in the aquatic environment – A review – Part I
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“1992). However, very often it was speculated on resistance connected to comparatively low concentrations of antibiotics in waters without any experimental data (e.g. Hirsch et al., 1999 ).”
BackgroundZhang, Q.-Q., Ying, G., Pan, C., Liu, Y., & Zhao, J. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00729 · Cited by 3,853
Luo, Y., Guo, W., Ngo, H. H., Nghiem, L. D., Hai, F. I., Zhang, J., Liang, S., & Wang, X. C. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2013.12.065 · Cited by 3,983
“Adapted from Alder, Hirsch et al. (1999), Huschek et al.”
Metadata
- Authors
- Hirsch, R., Ternes, T., Haberer, K., & Kratz, K.-L.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 225
- Issue
- 1-2
- Pages
- 109-118
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2029593210
- Cited by
- 2,140
- References
- 32
- Citations by year
- 2026: 19 · 2025: 37 · 2024: 48 · 2023: 54 · 2022: 74 · 2021: 83 · 2020: 100 · 2019: 93 · 2018: 117 · 2017: 103 · 2016: 102 · 2015: 112 · 2014: 121 · 2013: 113 · 2012: 124
- FWCI
- 25.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Science of The Total Environment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Ministry of Environment
- Topics
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Keywords
- antibiotic residues, aquatic environment, sewage treatment plant effluent, surface water, groundwater contamination, sulfonamides, penicillin, tetracycline, roxithromycin, sulfamethoxazole, veterinary antibiotic use, agricultural land
- MeSH terms
- Agriculture, Animals, Anti-Bacterial Agents, Bacteria, Biodegradation, Environmental, Drug Resistance, Microbial, Erythromycin, Germany, Humans, Sewage, Water Pollutants, Chemical
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