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Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance
Open accessAbstract
The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor.
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“Thrombopoietin synthesis in the liver is regulated by Jak2/STAT3”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Hoffmeister and Falet, 2016
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Metadata
- Authors
- Hoffmeister, K. M., & Falet, H.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Hoffmeister, Karin M.
- Venue
- Thrombosis Research
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 141
- Pages
- S68-S72
- ISSN
- 0049-3848 (ISSN-L)
- PMC
- PMC5399515
- OpenAlex
- W2399884037
- Cited by
- 86
- References
- 65
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 6 · 2017: 4 · 2016: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Thrombosis Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Society of Hematology
- National Institutes of Health
- Brigham Research Institute
- National Heart, Lung, and Blood Institute (R01HL126743, P01HL107146, R01HL089224)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- platelet clearance, platelet survival, post-translational modification, thrombopoietin, megakaryopoiesis, platelet homeostasis
- MeSH terms
- Animals, Blood Platelets, Humans, Protein Processing, Post-Translational, Thrombopoietin, Signal Transduction, Cellular Senescence, Receptors, Interleukin-6, Asialoglycoprotein Receptor
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