The scale−up of microbial batch and fed−batch fermentation processes
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Researchers would expect a higher yield of end-products from fed-batch fermentation because it entails a scale-up process.
“Given that the fed-batch fermentation system entails a scale-up process, researchers would expect a higher yield of end-products (Modak et al., 1986; Thiry and Cingolani, 2002; Hewitt and Nienow, 2007).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Hewitt and Nienow, 2007
The Introduction says that biomass yield and growth-associated products often decrease when aerobic fermentation is scaled up. Although ‘Operational Constraints at the large-scale’ describes fed-batch cultivation as a way to increase volumetric productivity, it does not attribute that increase to scale-up; the claimed reason for expecting a higher yield is contrary to the paper's account. (LLM, conf=0.91)
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Experimental — accuracy not yet measuredSometimes a large-scale fed-batch fermentation may not generate similar results as observed in small-scale batch fermentation, because the fed-batch fermentation system involves a more dynamic environment.
“However, it has been suggested that sometimes a large-scale fed-batch fermentation may not generate similar results as observed in small-scale batch fermentation, as the fed-batch fermentation system involves a more dynamic environment (Hewitt and Nienow, 2007).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Hewitt and Nienow, 2007
The Conclusions and Future Perspective section says large-scale fed-batch bioreactors have dynamic spatial and temporal heterogeneities that can reduce biomass and product yields relative to well-mixed laboratory reactors. However, the Experimental Results section compares large-scale fed-batch fermentation with small-scale fed-batch fermentation, not the small-scale batch fermentation specified in the claim. Page numbers are not available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Research works printed but not linked: 15
- Amanullah, A., Nienow, A. W. and Buckland, B. C. (2003). Mixing in the fermentation and cell culture industries. In 'Handbook of Industrial Mixing; Science and Practice' (E.L. Paul, V.A. Atiemo-Obeng and S.M. Kresta, Eds.), pp 1071-1157. Wiley-Interscience, New York.
- Einsele, A. (1978). Scaling-up of bioreactors. Proc. Biochem. 13, 13-14.
- Enfors, S. O. (2004). Preface. In Advances in Biochemical Engineering/Biotechnology -Physiological Stress Responses in Bioprocesses, (S. O. Enfors, Ed.), Vol. 89, pp ix -x. Springer, New York.
- Hewitt, C. J, Onyeaka, H., Lewis, G.,. Taylor I W and Nienow, A. W. (2007). A comparison of high cell density fed-batch fermentations involving both induced and non-induced recombinant Escherichia coli under well-mixed small-scale and simulated poorly-mixed large-scale conditions. Biotechnol. Bioeng. (In press).
- Hoffman, F. and Rinas, U. (2004). Stress induced by recombinant protein production in E. coli. In Advances in Biochemical Engineering/Biotechnology - Physiological Stress Responses in Bioprocesses, (S. O. Enfors, Ed.), Vol. 89, pp 73 -92. Springer, New York.
- Kresta, S. M. and Brodkey, R. S. (2003). Turbulence in mixing applications. In 'Handbook of Industrial Mixing; Science and Practice'. (E. L. Paul, V. A. Atiemo-Obeng and S. M. Kresta, Eds.), pp 19-87. Wiley-Interscience, NewYork.
- Middleton, J. C. and Smith, J. M. (2003). Gas-liquid mixing in turbulent systems. In 'Handbook of Industrial Mixing; Science and Practice'. (E. L. Paul, V. A. Atiemo-Obeng and S. M. Kresta, Eds.), pp 585 -635. Wiley-Interscience, New York.
- Nienow, A. W. (1998). Hydrodynamics of stirred bioreactors. In 'Fluid mechanics problems in biotechnology'. (R. Pohorecki, Ed.) App. Mech. Rev. 51, 3-32.
- Nienow, A. W. (2003). Aeration-Biotechnology. In 'Kirk Othmer Encyclopaedia of Chemical Technology, 5th Edition' (on-line), Wiley, New York.
- Nienow, A.W. (2005). Considerations of mixing at the pilot plant stage in bioreactors, Inz. Chem. I. Proc. 26, 395 -403.
- Schütze, J. and Hengstler, J. (2006). Assessing aerated bioreactor performance using CFD, Proc. 12th European Conference on Mixing, Bologna, June 2006; AIDIC, Milan, Italy, 439 -436.
- Schweder, T. and Hecker M. (2004). Monitoring of stress responses. In Advances in Biochemical Engineering/Biotechnology -Physiological Stress Responses in Bioprocesses, (S. O. Enfors, Ed.), Vol. 89, pp 47 -72. Springer, New York.
- Simmons M. J. H , Zhu, H., Bujalski, W., Hewitt, C. J. and Nienow, A.W. (2007). Mixing in bioreactors using agitators with a high solidity ratio and deep blades T. I. Chem Eng-Lond. A. (In press).
- Thomas, C. R., (1990) Problems of shear in biotechnology. In "Chemical Engineering Problems in Biotechnology", (M.A. Winkler, Ed.), pp 23 -94. Elsevier Applied Science, United Kingdom.
- Wick, L. M. and Egli, T. (2004). Molecular components of physiological stress responses in E. coli. In Advances in Biochemical Engineering/Biotechnology - Physiological Stress Responses in Bioprocesses, (S. O. Enfors, Ed.), Vol. 89, pp 1 -46. Springer, New York.
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“Given that the fed-batch fermentation system entails a scale-up process, researchers would expect a higher yield of end-products (Modak et al., 1986; Thiry and Cingolani, 2002; Hewitt and Nienow, 2007).”
BackgroundResult
- Authors
- Hewitt, C. J., & Nienow, A. W.
- Affiliations
- Loughborough University (GB)
- University of Birmingham (GB)
- Venue
- Advances in Applied Microbiology
- Publisher
- Elsevier
- Published
- 2007
- Volume
- 62
- Pages
- 105-135
- ISSN
- 0065-2164 (ISSN-L)
- OpenAlex
- W2768258932
- Cited by
- 162
- References
- 0
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 12 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 8
- FWCI
- 32.87
- Type
- book chapter
- Language
- en
- Open access
- green
- dspace.lboro.ac.uk
- Licence
- cc-by-nc-nd
- Locations
- Advances in applied microbiology (publishedVersion)
- PubMed (publishedVersion)
- Loughborough University Institutional Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Loughborough University Research Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Fluid Dynamics and Mixing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- scale-up, fed-batch fermentation, batch fermentation, microbial fermentation, spatiotemporal heterogeneity, physiological responses, shear damage, biomass concentration, product yield, feeding regime, bioreactor design
- MeSH terms
- Engineering, Fermentation, Bacterial Physiological Phenomena, Bioreactors
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