Factors and forces controlling V(D) J recombination
Integrity signals
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Each of the estimated 5 × 109 B-cells in an organism produces a distinct B-cell receptor or antibody through somatic recombination of variable, diversity, joining and constant gene segments.
“Each of the estimated 5 × 109 B-cells in an organism [23] produces a distinct B-cell receptor (membrane-bound) or antibody (in soluble form) through somatic recombination of variable (V), diversity (D), joining (J) and constant (C) gene segments [28, 29].”
From Computational approaches to therapeutic antibody design: established methods and emerging trends (2020) · cites this paper as [29]
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References 354 · Cited by 183
- Authors
- Hesslein, D. G. T., & Schatz, D. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Schatz, David G.
- ORCID
- Schatz, David G.
- Venue
- Advances in immunology
- Publisher
- Elsevier
- Published
- 2001
- Volume
- 78
- Pages
- 169-232
- ISSN
- 0065-2776 (ISSN-L)
- OpenAlex
- W169519822
- Cited by
- 183
- References
- 354
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 8
- FWCI
- 37.18
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI07019, T32AI007019)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- V(D)J recombination, DNA double-strand breaks, chromosomal translocation, B cells, antibody gene rearrangement, genomic instability, B-cell malignancies, health disparities, underrepresented groups
- MeSH terms
- Animals, Chromatin, DNA-Binding Proteins, Genes, Immunoglobulin, Humans, Immunoglobulin Joining Region, Immunoglobulin Variable Region, Immunoglobulin Heavy Chains, Models, Genetic, Nuclear Proteins, Nucleosomes, Receptors, Antigen, T-Cell, Recombination, Genetic, Homeodomain Proteins, DNA Methylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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