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Immortalizing Genes of Epstein-Barr Virus

Middleton, Tim, Gahn, Toni A., Martin, Jennifer M., Sugden, Bill·1991·Advances in Virus Research
DOI 10.1016/s0065-3527(08)60276-6
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Abstract

EBV immortalizes human B lymphocytes efficiently. Ten of its approximately 100 genes are expressed in these proliferating lymphoblasts and are candidates for mediating the changes central to the immortalization of the cell. Enough has been learned now about three of these viral genes to indicate that they are likely to be required for immortalization. As more is learned, additional genes of EBV will probably be found to support the process of immortalization of the host cell. EBNA-2 has been shown genetically to be required for EBV to immortalize an infected B lymphocyte. The biochemical activities of EBNA-2 that constitute this requirement have not been identified. Many experiments indicate that EBNA-2 affects the accumulation of specific viral and cellular RNAs. These effects, however, can be detected only in certain EBV-negative B-lymphoblastoid cells. It is, therefore, not clear that the known effects of EBNA-2 adequately explain its ubiquitous requirement in the immortalization of primary human B lymphocytes. LMP is likely to be required for immortalization because it can affect the growth properties of established human lymphoid and epithelial cells and can transform at least two established rodent cells to proliferate in an anchorage-independent manner. The structure of this viral protein, its position in the plasma membrane, many of its biochemical properties, as well as studies of its mutant derivatives are consistent with its acting as a growth factor receptor or af…

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  1. Abbot, 1990, Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein, J. Virol., 64, 2126, 10.1128/JVI.64.5.2126-2134.1990 · DOI
  2. Adams, 1987, Replication of latent Epstein-Barr virus genomes in Raji cells, J. Virol., 61, 1743, 10.1128/JVI.61.5.1743-1746.1987 · DOI
  3. Adams, 1989, Replication of latent Epstein-Barr virus genomes in normal and malignant lymphoid cells, Int. J. Cancer, 44, 560, 10.1002/ijc.2910440331 · DOI
  4. Allday, 1989, Epstein-Barr virus latent gene expression during the initiation of B-cell immortalization, J. Gen. Virol., 70, 1755, 10.1099/0022-1317-70-7-1755 · DOI
  5. Altiok, 1989, Epstein-Barr virus-transformed pro-B-cells are prone to illegitimate recombination between the switch region of the μ chain gene and other chromosomes, Proc. Natl. Acad. Sci. U.S.A., 86, 6333, 10.1073/pnas.86.16.6333 · DOI
  6. Aman, 1990, An Epstein-Barr virus immortalization associated gene segment interferes specifically with the IFN-induced anti-proliferative response in human B-lymphoid cell lines, EMBO J., 9, 147, 10.1002/j.1460-2075.1990.tb08090.x · DOI
  7. Ambinder, 1990, Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA, J. Virol., 64, 2369, 10.1128/JVI.64.5.2369-2379.1990 · DOI
  8. Arrand, 1989, Two families of sequences in the small RNA-encoding region of Epstein-Barr virus (EBV) correlate with EBV types A and B, J. Virol., 63, 983, 10.1128/JVI.63.2.983-986.1989 · DOI
  9. Baer, 1984, DNA sequence and expression of the B95-8 Epstein-Barr virus genome, Nature (London), 310, 207, 10.1038/310207a0 · DOI
  10. Baichwal, 1987, Posttranslational processing of an Epstein-Barr virus-encoded membrane protein expressed in cells transformed by Epstein-Barr virus, J. Virol., 61, 866, 10.1128/JVI.61.3.866-875.1987 · DOI
  11. Baichwal, 1988, Transformation of BALB/c 3T3 cells by the BNLF-1 gene of Epstein-Barr virus, Oncogene, 2, 461
  12. Baichwal, 1989, The multiple membrane-spanning segments of the BNLF-1 oncogene from Epstein-Barr virus are required for transformation, Oncogene, 4, 67
  13. Bankier, 1983, DNA sequence analysis of the EcoRI Dhet fragment of B95-8 Epstein-Barr virus containing the terminal repeat sequences, Mol. Biol. Med., 1, 425
  14. Baumann, 1988, Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems, EMBO J., 7, 2457, 10.1002/j.1460-2075.1988.tb03092.x · DOI
  15. Bird, 1979, A new approach to the study of human B-lymphocyte function using an indirect plaque assay and a direct B-cell activator, Immunol. Rev., 45, 41, 10.1111/j.1600-065X.1979.tb00272.x · DOI
  16. Bodescot, 1986, Epstein-Barr virus mRNAs produced by alternative splicing, Nucleic Acids Res., 14, 7103, 10.1093/nar/14.17.7103 · DOI
  17. Boni-Schnetzler, 1987, Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding, Proc. Natl. Acad. Sci. U.S.A., 84, 7832, 10.1073/pnas.84.22.7832 · DOI
  18. Brown, 1982, Immunoglobulin expression by human B-lymphocytes clonally transformed by Epstein-Barr virus, J. Immunol., 128, 24, 10.4049/jimmunol.128.1.24 · DOI
  19. Burhans, 1990, Identification of an origin of bidirectional DNA replication in mammalian chromosomes, Cell, 62, 955, 10.1016/0092-8674(90)90270-O · DOI
  20. Cheah, 1986, fgr proto-oncogene mRNA induced in B-lymphocytes by Epstein-Barr virus infection, Nature (London), 319, 238, 10.1038/319238a0 · DOI
  21. Chittenden, 1989, Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication, J. Virol., 63, 3016, 10.1128/JVI.63.7.3016-3025.1989 · DOI
  22. Cohen, 1989, Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation, Proc. Natl. Acad. Sci. U.S.A., 86, 9558, 10.1073/pnas.86.23.9558 · DOI
  23. Contreras-Salazar, 1989, Host cell-dependent regulation of growth transformation-associated Epstein-Barr virus antigens in somatic cell hybrids, J. Virol., 63, 2768, 10.1128/JVI.63.6.2768-2772.1989 · DOI
  24. Cordier, 1990, Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23, J. Virol., 64, 1002, 10.1128/JVI.64.3.1002-1013.1990 · DOI
  25. Crow, 1986, Direct T helper-B-cell interactions induce an early B-cell activation antigen, J. Exp. Med., 164, 1760, 10.1084/jem.164.5.1760 · DOI
  26. Dambaugh, 1984, U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2, Proc. Natl. Acad. Sci. U.S.A., 81, 7632, 10.1073/pnas.81.23.7632 · DOI
  27. Dawson, 1990, Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation, Nature (London), 344, 777, 10.1038/344777a0 · DOI
  28. DePamphilis, 1988, Transcriptional elements as components of eukaryotic origins of DNA replication, Cell, 52, 635, 10.1016/0092-8674(88)90398-4 · DOI
  29. de The, 1978, Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study, Nature (London), 274, 756, 10.1038/274756a0 · DOI
  30. Ernberg, 1987, Progenitor and pre-B-lymphocytes transformed by Epstein-Barr virus, Int. J. Cancer, 39, 190, 10.1002/ijc.2910390212 · DOI
  31. Fahraeus, 1990, Epstein-Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element, Proc. Natl. Acad. Sci. U.S.A., 87, 7390, 10.1073/pnas.87.19.7390 · DOI
  32. Fahraeus, 1990, Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus, Nature (London), 345, 447, 10.1038/345447a0 · DOI
  33. Fennewald, 1984, Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein, J. Virol., 51, 411, 10.1128/JVI.51.2.411-419.1984 · DOI
  34. Gahn, 1989, The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication, Cell, 58, 527, 10.1016/0092-8674(89)90433-9 · DOI
  35. Ghosh, 1990, cis-Acting regulatory elements near the Epstein-Barr virus latent-infection membrane protein transcriptional start site, J. Virol., 64, 1855, 10.1128/JVI.64.4.1855-1858.1990 · DOI
  36. Given, 1979, DNA of Epstein-Barr virus: V. Direct repeats of the ends of Epstein-Barr virus DNA, J. Virol., 30, 852, 10.1128/JVI.30.3.852-862.1979 · DOI
  37. Glenney, 1988, Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies, Cell, 52, 675, 10.1016/0092-8674(88)90405-9 · DOI
  38. Gordon, 1986, Control of human B-lymphocyte replication. II. Transforming Epstein-Barr virus exploits three distinct viral signals to undermine three separate control points in B-cell growth, Immunology, 58, 591
  39. Gregory, 1990, Different Epstein-Barr virus-B-cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line, J. Gen. Virol., 71, 1481, 10.1099/0022-1317-71-7-1481 · DOI
  40. Gross, 1983, Down-regulation of epidermal growth factor receptor correlates with plasminogen activator activity in human A431 epidermoid carcinoma cells, Proc. Natl. Acad. Sci. U.S.A., 80, 2276, 10.1073/pnas.80.8.2276 · DOI
  41. Gutkind, 1991, A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes, Mol. Cell. Biol., 11, 1500, 10.1128/MCB.11.3.1500 · DOI
  42. Hammerschmidt, 1989, Genetic analysis of immortalizing functions of Epstein-Barr virus in human B-lymphocytes, Nature (London), 340, 393, 10.1038/340393a0 · DOI
  43. Hammerschmidt, 1989, The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels, J. Virol., 63, 2469, 10.1128/JVI.63.6.2469-2475.1989 · DOI
  44. Hampar, 1974, Replication of the resident repressed Epstein-Barr virus genome during the early S phase (S-1 period) of nonproducer Raji cells, Proc. Natl. Acad. Sci. U.S.A., 71, 631, 10.1073/pnas.71.3.631 · DOI
  45. Hanley, 1987, Substance K receptor: Return of the magnificent seven, Nature (London), 329, 766, 10.1038/329766a0 · DOI
  46. Heinzel, 1988, Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells, J. Virol., 62, 3738, 10.1128/JVI.62.10.3738-3746.1988 · DOI
  47. Henderson, 1977, Efficiency of transformation of lymphocytes by Epstein-Barr virus, Virology, 76, 152, 10.1016/0042-6822(77)90292-6 · DOI
  48. Hennessy, 1984, A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infection, Proc. Natl. Acad. Sci. U.S.A., 81, 7207, 10.1073/pnas.81.22.7207 · DOI
  49. Hinuma, 1967, Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line, J. Virol., 1, 1045, 10.1128/JVI.1.5.1045-1051.1967 · DOI
  50. Jones, 1989, Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen (EBNA-1) with its DNA-binding sites, J. Virol., 63, 101, 10.1128/JVI.63.1.101-110.1989 · DOI
  51. Katamine, 1984, Epstein-Barr virus transforms precursor B-cells even before immunoglobulin gene rearrangements, Nature (London), 309, 369, 10.1038/309369a0 · DOI
  52. Kawakami, 1986, Isolation and oncogenic potential of a novel human src-like gene, Mol. Cell. Biol., 6, 4195, 10.1128/MCB.6.12.4195 · DOI
  53. Kimball, 1989, High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1, Mol. Cell. Biol., 9, 2738, 10.1128/MCB.9.6.2738 · DOI
  54. Kintner, 1979, The structure of the termini of the DNA of Epstein-Barr virus, Cell, 17, 661, 10.1016/0092-8674(79)90273-3 · DOI
  55. Kintner, 1981, Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells, J. Virol., 38, 305, 10.1128/JVI.38.1.305-316.1981 · DOI
  56. Kintner, 1981, Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein-Barr virus, Nature (London), 294, 458, 10.1038/294458a0 · DOI
  57. Klein, 1989, Viral latency and transformation: The strategy of Epstein-Barr virus, Cell, 58, 5, 10.1016/0092-8674(89)90394-2 · DOI
  58. Klein, 1988, Expression of the c-fgr related transcripts in Epstein-Barr virus-associated malignancies, Int. J. Cancer, 42, 29, 10.1002/ijc.2910420107 · DOI
  59. Klein, 1974, Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx, Proc. Natl. Acad. Sci. U.S.A., 71, 4737, 10.1073/pnas.71.12.4737 · DOI
  60. Knutson, 1990, The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization, J. Virol., 64, 2530, 10.1128/JVI.64.6.2530-2536.1990 · DOI
  61. Knutson, 1985, The effects of cycloheximide and chloroquine on insulin receptor metabolism. Differential effects on receptor recycling and inactivation and insulin degradation, J. Biol. Chem., 260, 14180, 10.1016/S0021-9258(17)38700-8 · DOI
  62. Kozbor, 1979, Establishment of anti-TNP antibody-producing human lymphoid lines by preselection for hapten binding followed by EBV transformation, Scand. J. Immunol., 10, 187, 10.1111/j.1365-3083.1979.tb01339.x · DOI
  63. Kuchler, 1989, Saccharomyces cerevisiae STE6 gene product: A novel pathway for protein export in eukaryotic cells, EMBO J., 8, 3973, 10.1002/j.1460-2075.1989.tb08580.x · DOI
  64. Ley, 1989, Tissue-specific expression and developmental regulation of the human fgr proto-oncogene, Mol. Cell. Biol., 9, 92, 10.1128/MCB.9.1.92 · DOI
  65. Liebowitz, 1986, Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus, J. Virol., 58, 233, 10.1128/JVI.58.1.233-237.1986 · DOI
  66. Liebowitz, 1987, An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes, Mol. Cell. Biol., 7, 2299, 10.1128/MCB.7.7.2299 · DOI
  67. Lindahl, 1976, Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line, J. Mol. Biol., 102, 511, 10.1016/0022-2836(76)90331-4 · DOI
  68. Lupton, 1985, Mapping genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells, Mol. Cell. Biol., 5, 2533, 10.1128/MCB.5.10.2533 · DOI
  69. Mann, 1987, Posttranslational processing of the Epstein-Barr virus-encoded p63/LMP protein, J. Virol., 61, 2100, 10.1128/JVI.61.7.2100-2108.1987 · DOI
  70. Mann, 1985, Epstein-Barr virusencoded protein found in plasma membranes of transformed cells, J. Virol., 55, 710, 10.1128/JVI.55.3.710-720.1985 · DOI
  71. Mark, 1982, Transformation of lymphocytes by Epstein-Barr virus requires only one-fourth of the viral genome, Virology, 122, 431, 10.1016/0042-6822(82)90242-2 · DOI
  72. J.M. Martin B. Sugden (1991b). Transformation by the LMP onco-protein correlates with its rapid turnover, membrane localization, and cytoskeletal association. Submitted for publication. · DOI
  73. Mermod, 1989, The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain, Cell, 58, 741, 10.1016/0092-8674(89)90108-6 · DOI
  74. Miller, 1973, Release of infectious Epstein-Barr virus by transformed marmoset leukocytes, Proc. Natl. Acad. Sci. U.S.A., 70, 190, 10.1073/pnas.70.1.190 · DOI
  75. Milman, 1987, Epstein-Barr virus nuclear antigen forms a complex that binds with high concentration dependence to a single DNA-binding site, J. Virol., 61, 465, 10.1128/JVI.61.2.465-471.1987 · DOI
  76. Moorthy, 1990, Processing of the Epstein-Barr virus-encoded latent membrane protein p63/LMP, J. Virol., 64, 829, 10.1128/JVI.64.2.829-837.1990 · DOI
  77. Murray, 1988, Different patterns of Epstein-Barr virus gene expression and of cytotoxic T-cell recognition in B-cell lines infected with transforming (B95-98) or nontransforming (P3HR1) virus strains, J. Virol., 62, 894, 10.1128/JVI.62.3.894-901.1988 · DOI
  78. Niederman, 1968, Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies, JAMA, J. Am. Med. Assoc., 203, 205, 10.1001/jama.1968.03140030037009 · DOI
  79. Nilsson, 1982, Phenotypic and cytogenetic characteristics of human B-lymphoid cell lines and their relevance for the etiology of Burkitt's lymphoma, Adv. Cancer Res., 37, 319, 10.1016/S0065-230X(08)60886-6 · DOI
  80. Otsu, 1987, Molecular characterization of novel reciprocal translocation t(6;14) in an Epstein-Barr virus-transformed B-cell precursor, Mol. Cell Biol., 7, 708, 10.1128/MCB.7.2.708 · DOI
  81. Pattengale, 1973, Selective transformation of B-lymphocytes by Epstein-Barr virus, Lancet, 2, 93, 10.1016/S0140-6736(73)93286-8 · DOI
  82. Paul, 1990, Epstein-Barr virus transformed B-lymphocytes produce interleukin-5, Blood, 75, 1400, 10.1182/blood.V75.7.1400.1400 · DOI
  83. Petti, 1990, Subnuclear localization and phosphorylation of Epstein-Barr virus latent infection nuclear proteins, Virology, 176, 563, 10.1016/0042-6822(90)90027-O · DOI
  84. Polvino-Bodnar, 1988, Mutational analysis of Epstein-Barr virus nuclear antigen 1 (EBNA-1), Nucleic Acids Res., 16, 3415, 10.1093/nar/16.8.3415 · DOI
  85. Pope, 1968, Transformation of foetal human leukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus, Int. J. Cancer, 3, 857, 10.1002/ijc.2910030619 · DOI
  86. Rabson, 1982, Non-immortalizing P3J-HR-1 Epstein-Barr virus: A deletion mutant of its transforming parent, Jijoye, J. Virol., 44, 834, 10.1128/JVI.44.3.834-844.1982 · DOI
  87. Rawlins, 1985, Sequencespecific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region, Cell, 42, 859, 10.1016/0092-8674(85)90282-X · DOI
  88. Reisman, 1986, Transactivation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1, Mol. Cell. Biol., 6, 3838, 10.1128/MCB.6.11.3838 · DOI
  89. Reisman, 1985, A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components, Mol. Cell. Biol., 5, 1822, 10.1128/MCB.5.8.1822 · DOI
  90. Rickinson, 1987, Influence of the Epstein-Barr virus nuclear antigen EBNA-2 on the growth phenotype of virus-transformed B-cells, J. Virol., 61, 1310, 10.1128/JVI.61.5.1310-1317.1987 · DOI
  91. Roberts, 1986, Negative control of DNA replication in composite SV40-bovine papilloma virus plasmids, Cell, 46, 741, 10.1016/0092-8674(86)90350-8 · DOI
  92. Roberts, 1988, cis-Acting negative control of DNA replication in eukaryotic cells, Cell, 52, 397, 10.1016/S0092-8674(88)80032-1 · DOI
  93. Robinson, 1981, Infection of human B-lymphocytes with high multiplicities of Epstein-Barr virus: Kinetics of EBNA expression, cellular DNA synthesis, and mitosis, Virology, 109, 336, 10.1016/0042-6822(81)90504-3 · DOI
  94. Woisetschlaeger, 1990, Alternative splicing dictates translational start in Epstein-Barr virus transcripts, EMBO J., 9, 2273, 10.1002/j.1460-2075.1990.tb07398.x · DOI
  95. Rooney, 1989, Influences of Burkitt's lymphoma and primary B-cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus, J. Virol., 63, 1531, 10.1128/JVI.63.4.1531-1539.1989 · DOI
  96. Rowe, 1985, Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1, Proc. Natl. Acad. Sci. U.S.A., 82, 7429, 10.1073/pnas.82.21.7429 · DOI
  97. Rowe, 1989, Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins, J. Virol., 63, 1031, 10.1128/JVI.63.3.1031-1039.1989 · DOI
  98. Sample, 1990, Transcription of the Epstein-Barr virus genome during latency in growth-transformed lymphocytes, J. Virol., 64, 1667, 10.1128/JVI.64.4.1667-1674.1990 · DOI
  99. Sample, 1986, Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: A probable transcriptional initiation site, Proc. Natl. Acad. Sci. U.S.A., 83, 5096, 10.1073/pnas.83.14.5096 · DOI
  100. Sample, 1990, Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes, J. Virol., 64, 4084, 10.1128/JVI.64.9.4084-4092.1990 · DOI
  101. Schmidt, 1986, Biosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons, Cell, 46, 437, 10.1016/0092-8674(86)90664-1 · DOI
  102. Speck, 1985, Analysis of the transcript encoding the latent Epstein-Barr virus nuclear antigen I: A potentially polycistronic message generated by long-range splicing of several exons, Proc. Natl. Acad. Sci. U.S.A., 82, 8305, 10.1073/pnas.82.24.8305 · DOI
  103. Speck, 1989, Transcription of Epstein-Barr virus in latently infected, growth-transformed lymphocytes, Adv. Viral Oncol., 8, 133
  104. Speck, 1986, An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide, Proc. Natl. Acad. Sci. U.S.A., 83, 9298, 10.1073/pnas.83.24.9298 · DOI
  105. Springer, 1990, Adhesion receptors of the immune system, Nature (London), 346, 425, 10.1038/346425a0 · DOI · Paper page
  106. Stern, 1988, Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo, Mol. Cell. Biol., 8, 3969, 10.1128/MCB.8.9.3969 · DOI
  107. Sternas, 1990, The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (EBV) DNA molecules per cell among different clones of EBV-immortalized cells, J. Virol., 64, 2407, 10.1128/JVI.64.5.2407-2410.1990 · DOI
  108. Sugden, 1977, Clonal transformation of adult human leukocytes by Epstein-Barr virus, J. Virol., 23, 503, 10.1128/JVI.23.3.503-508.1977 · DOI
  109. Sugden, 1983, Characterization of an antigen whose cell surface expression is induced by infection with Epstein-Barr virus, J. Virol., 46, 800, 10.1128/JVI.46.3.800-807.1983 · DOI
  110. Sugden, 1989, A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection, J. Virol., 63, 2644, 10.1128/JVI.63.6.2644-2649.1989 · DOI
  111. Swendeman, 1987, The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B-cells, EMBO J., 6, 1637, 10.1002/j.1460-2075.1987.tb02412.x · DOI
  112. Tempel, 1987, Sequence of a probable potassium channel component encoded at shaker locus of Drosophila, Science, 237, 770, 10.1126/science.2441471 · DOI
  113. Thorley-Lawson, 1985, BLAST-2 [EBVCS], an early cell surface marker of human B-cell activation, is superinduced by Epstein Barr virus, J. Immunol., 134, 3007, 10.4049/jimmunol.134.5.3007 · DOI
  114. Tosato, 1990, Identification of interleukin-6 as an autocrine growth factor for Epstein-Barr virus-immortalized cells, J. Virol., 64, 3033, 10.1128/JVI.64.6.3033-3041.1990 · DOI
  115. Uchibayashi, 1989, Recombinant soluble Fe epsilon receptor II (Fc epsilon RII/CD23) has IgE binding activity but no B-cell growth promoting activity, J. Immunol., 142, 3901, 10.4049/jimmunol.142.11.3901 · DOI
  116. Veillette, 1988, The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck, Cell, 55, 301, 10.1016/0092-8674(88)90053-0 · DOI
  117. Vidal, 1990, Differences in human cell lines to support stable replication of Epstein-Barr virus-based vectors, Biochim. Biophys. Acta, 1048, 171, 10.1016/0167-4781(90)90053-5 · DOI
  118. Wang, 1985, An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells, Cell, 43, 831, 10.1016/0092-8674(85)90256-9 · DOI
  119. Wang, 1988, Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: Deletion of the amino terminus abolishes activity, J. Virol., 62, 4173, 10.1128/JVI.62.11.4173-4184.1988 · DOI
  120. Wang, 1987, Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23, Proc. Natl. Acad. Sci. U.S.A., 84, 3452, 10.1073/pnas.84.10.3452 · DOI
  121. Wang, 1990, Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B-lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23, J. Virol., 64, 2309, 10.1128/JVI.64.5.2309-2318.1990 · DOI
  122. Wang, 1990, Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1, J. Virol., 64, 3407, 10.1128/JVI.64.7.3407-3416.1990 · DOI
  123. Weiner, 1989, A point mutation in the neu oncogene mimics ligand induction of receptor aggregation, Nature (London), 339, 230, 10.1038/339230a0 · DOI
  124. Wilson, 1990, Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6, Cell, 61, 1315, 10.1016/0092-8674(90)90695-B · DOI
  125. Woisetschlaeger, 1989, Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes, Proc. Natl. Acad. Sci. U.S.A., 86, 6498, 10.1073/pnas.86.17.6498 · DOI
  126. Woisetschlaeger, 1990, Promoter switching in Epstein-Barr virus during the initial stages of infection of B-lymphocytes, Proc. Natl. Acad. Sci. U.S.A., 87, 1725, 10.1073/pnas.87.5.1725 · DOI
  127. Wysokenski, 1989, Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus, J. Virol., 63, 2657, 10.1128/JVI.63.6.2657-2666.1989 · DOI
  128. Yates, 1988, Dissection of DNA replication and enhancer activation functions of Epstein-Barr virus nuclear antigen 1, Cancer Cells, 6, 197
  129. Yates, 1985, Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells, Nature (London), 313, 812, 10.1038/313812a0 · DOI
  130. Yokoi, 1990, Epstein-Barr virus-immortalized B-cells produce IL-6 as an autocrine growth factor, Immunology, 70, 100
  131. Yokota, 1988, Two species of human Fc receptor II (FcRII/CD23): Tissuespecific and IL-4-specific regulation of gene expression, Cell, 55, 611, 10.1016/0092-8674(88)90219-X · DOI
  132. Zimber-Strobl, 1991, Epstein-Barr virus nuclear antigen-2 activates transcription of the terminal protein gene, J. Virol., 65, 415, 10.1128/JVI.65.1.415-423.1991 · DOI

Cited by

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Metadata

Authors
Middleton, T., Gahn, T. A., Martin, J. M., & Sugden, B.
Venue
Advances in Virus Research
Publisher
Elsevier
Published
1991
Pages
19-55
ISSN
0065-3527
DOI
10.1016/s0065-3527(08)60276-6
Cited by
42
References
1
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Immortalizing Genes of Epstein-Barr Virus. https://app.cochat.ai/papers/10.1016/s0065-3527(08)60276-6
The paper
Middleton, T., Gahn, T. A., Martin, J. M., & Sugden, B. (1991). Immortalizing Genes of Epstein-Barr Virus. Advances in Virus Research. https://doi.org/10.1016/s0065-3527(08)60276-6