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Cited by 7Diabetes Management and ResearchPancreatic function and diabetesDiabetes Treatment and Management

Dynamic network model of glucose counterregulation in subjects with insulin-requiring diabetes

Kovatchev, Boris P., Straume, Martin, Farhy, Leon S., Cox, Daniel J.·2000·Methods in Enzymology
DOI 10.1016/s0076-6879(00)21204-4
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Crossref · 10.1016/s0076-6879(00)21204-4

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  • The phenomenon of insulin action paradoxically increasing when glucose decreases under a given threshold has been described during hyperinsulinemic clamps in T1DM.

    “This phenomenon has been described during hyperinsulemic clamps in T1DM. 9,10”

    From The UVA/PADOVA Type 1 Diabetes Simulator: New Features (2014) · cites this paper as [10]

  • When glucose falls below a given threshold, insulin sensitivity increases, resulting in enhanced glucose utilization and further reduction of plasma glucose.

    “Results in T1DM subjects suggest that, when glucose falls below a given threshold, insulin sensitivity increases, resulting in an enhanced glucose utilization, which further reduces the plasma glucose level.4–6”

    From The university of Virginia/Padova type 1 diabetes simulator matches the glucose traces of a clinical trial (2014) · cites this paper as [5]

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Related

Authors
Kovatchev, B. P., Straume, M., Farhy, L. S., & Cox, D. J.
Affiliations
University of Virginia Health System (US)
ORCID
Venue
Methods in Enzymology
Publisher
Elsevier
Published
2000
Volume
321
Pages
396-410
ISSN
0076-6879 (ISSN-L)
DOI
10.1016/s0076-6879(00)21204-4
OpenAlex
W1678778362
Cited by
7
References
27
Citations by year
2017: 1 · 2014: 3
FWCI
1.49
Type
book chapter
Language
en
Open access
closed
Locations
  • Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • University of Virginia
  • National Institutes of Health (5r01dk051562-23, 5r01dk028288-27)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK 51562, R01 DK28288)
  • National Center for Research Resources (RROO847, M01RR000847)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
glucose counterregulation, type 1 diabetes, dynamic network model, glycemic control, hypoglycemia, counterregulatory hormones, insulin therapy, glycemic variability, glucose homeostasis
MeSH terms
Adult, Algorithms, Blood Glucose, Diabetes Mellitus, Type 1, Epinephrine, Female, Humans, Hypoglycemia, Insulin, Male, Models, Biological, Time Factors

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