The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Impact of prosocial neuropeptides on human brain function
Abstract
Oxytocin and vasopressin are key effectors of social behaviour (Insel, T. R. and Fernald, R. D. (2004). Annu. Rev. Neurosci., 27: 697-722). Oxytocin effects in humans were recently demonstrated by a behavioural study showing selectively increased trust after hormone administration (Kosfeld, M., et al. (2005). Nature, 435: 673-676). Since this suggested involvement of the amygdala, which is linked to trust (Winston, J. S., et al. (2002). Nat. Neurosci., 5: 277-283) - presumably because of its role in danger monitoring - and highly expresses oxytocin receptors (Huber, D., et al. (2005). Science, 308: 245-248), we studied amygdala circuitry after double-blind crossover intranasal application of placebo or oxytocin (Kirsch, P., et al. (2005). J. Neurosci., 25: 11489-11493). Oxytocin potently reduced amygdala activation and decreased coupling to brainstem regions implicated in autonomic and behavioural manifestations of fear, indicating a neural mechanism for the effects of oxytocin in social cognition in humans and providing a potential therapeutic approach to social anxiety currently being tested in social phobia and autism. Furthermore, these data suggested a translational genetic approach. Preliminary findings (data not presented) from our laboratory using imaging genetics indeed implicate genetic variants for both AVPR1A, encoding the primary receptor of vasopressin in brain, and the oxytocin receptor, OXTR, in amygdala regulation and activation. Taken together, our results indicate neural mechanisms for human social behaviour mediating genetic risk for autism through an impact on amygdala signalling and provide a rationale for exploring therapeutic strategies aimed at abnormal amygdala function in this disorder and in social dysfunction in general.
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“Oxytocin has received substantial interest as a potential treatment for psychiatric conditions such as autism spectrum conditions (ASC; henceforth autism),3 although clinical trials show modest effects.4, 5, 6”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [3]
Citations
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
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Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.4 · Cited by 1,997
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Self-citationCognitive neuroscience of human social behaviour
Adolphs, R. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1056 · Cited by 1,657
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Self-citationA mechanism for impaired fear recognition after amygdala damage
Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005) · Nature · doi:10.1038/nature03086 · Cited by 1,331 · cited 6×
“…potently activate amygdala (Whalen et al., 1998), lesions of the amygdala impair recognition of fearful faces and lead to social disinhibition (Adolphs et al., 2005), and decreased amygdala activation has been linked to genetic hypersociability (Meyer-Lindenberg et al., 2005) and increased…”
BackgroundResultInfluentialOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
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Pakyürek, G. (2020) · Yaşam Becerileri Psikoloji Dergisi · doi:10.31461/ybpd.719978
Kapfhammer, H. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_57
Bases hormonals de la conducta prosocial: una revisió de la literatura
Lerma, F. S., Manuel, M. V., & Susana, L. T. (2016) · Anuari de Psicologia de la Societat Valenciana de Psicologia · doi:10.7203/anuari.psicologia.15.2.189
Neural Basis of Empathy and Its Dysfunction in Autism Spectrum Disorders (ASD)
Platt, M. L. (2014) · Defense Technical Information Center (DTIC) · doi:10.21236/ada612863
Forensically relevant challenging behaviors and the genetics domain
Egger, J. I. M., & Verhoeven, W. M. A. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-821375-9.00007-4
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Dissecting the role of calcium signaling in Fragile X syndrome
Castagnola, S. (2019) · theses.fr (ABES) · doi:10.70675/3d35096bz79d0z46edz8a70zb783a8f60257
Angst- oder furchtbezogene Störungen
Domschke, K., & Zwanzger, P. (2026) · Springer Reference Medizin · doi:10.1007/978-3-642-45028-0_69-2
BEHAVIOURAL AND NEUROBIOLOGICAL CORRELATES OF MATERNAL SENSITIVITY IN HEALTHY NEW MOTHERS
Elmadih, A. (2013) · Research Explorer (The University of Manchester)
Metadata
- Authors
- MEYERLINDENBERG, A.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2008
- Volume
- 170
- Pages
- 463-470
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1480002351
- Cited by
- 109
- References
- 61
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 11
- FWCI
- 29.85
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, amygdala, social behavior, trust, social anxiety, social anxiety disorder, autism spectrum disorder, AVPR1A, oxytocin receptor, imaging genetics, genetic risk
- MeSH terms
- Administration, Intranasal, Amygdala, Animals, Autistic Disorder, Brain, Brain Stem, Cognition, Humans, Neuropeptides, Oxytocin, Social Behavior, Genetic Variation, Signal Transduction, Receptors, Vasopressin, Receptors, Oxytocin, Mice, Knockout, Recognition, Psychology, Models, Animal, Mice
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