Human neuroimaging of oxytocin and vasopressin in social cognition
Open accessAbstract
The neuropeptides oxytocin and vasopressin have increasingly been identified as modulators of human social behaviors and associated with neuropsychiatric disorders characterized by social dysfunction, such as autism. Identifying the human brain regions that are impacted by oxytocin and vasopressin in a social context is essential to fully characterize the role of oxytocin and vasopressin in complex human social cognition. Advances in human non-invasive neuroimaging techniques and genetics have enabled scientists to begin to elucidate the neurobiological basis of the influence of oxytocin and vasopressin on human social behaviors. Here we review the findings to-date from investigations of the acute and chronic effects of oxytocin and vasopressin on neural activity underlying social cognitive processes using "pharmacological fMRI" and "imaging genetics", respectively. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
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Zink and Meyer-Lindenberg (2012) found that vasopressin decreased amygdala to medial prefrontal connectivity in a group of healthy volunteers.
“Interestingly, Zink and Meyer-Lindenberg (2012) found that vasopressin, which is thought to have an effect opposite to OXT by enhancing fear and anxiety (Viviani and Stoop, 2008), decreased amygdala to medial prefrontal connectivity in group of healthy volunteers.”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Zink and Meyer-Lindenberg, 2012
Oxytocin plays an important role in social interaction and social decision-making, including promoting social motivation, increasing trust and cooperation with own-group members, and reducing social distance.
“Oxytocin has been found to play an important role in social interaction and social decision-making 22 , including promoting social motivation 23 , increasing trust and cooperation with own-group members 24 , and reducing social distance 25 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [22]
Oxytocin has been implicated in many social behaviors, from promoting trust, generosity and cooperation to aggravating mistrust and aggressive behavior.
“Oxytocin has been implicated in many social behaviors, from promoting trust, generosity and cooperation 21,22,46,47 to aggravating mistrust and aggressive behavior 48,49 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [22]
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“Insights into the neural mechanisms of OT action in humans have been gained using brain imaging (Zink and Meyer-Lindenberg, 2012), but inferences on precise mechanisms of action based on these techniques are limited compared to studies using animal models.”
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- Authors
- Zink, C. F., & Meyer-Lindenberg, A.
- Affiliations
- United States Department of Health and Human Services (US)
- Corresponding author
- Zink, Caroline F.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 61
- Issue
- 3
- Pages
- 400-409
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3312952
- OpenAlex
- W2046962905
- Cited by
- 176
- References
- 87
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 12 · 2022: 5 · 2021: 15 · 2020: 7 · 2019: 9 · 2018: 13 · 2017: 8 · 2016: 17 · 2015: 16 · 2014: 28 · 2013: 26 · 2012: 7
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, vasopressin, social cognition, social behavior, autism spectrum disorder, pharmacological fMRI, imaging genetics, neuropeptides, brain regions, neuropsychiatric disorders
- MeSH terms
- Amygdala, Animals, Cognition, Humans, Magnetic Resonance Imaging, Oxytocin, Social Behavior, Genetic Variation, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, Neuroimaging
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