Chapter 6 Glutamate receptors and the induction of excitotoxic neuronal death

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Glutamate receptor channels: novel properties and new clones

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Potassium Channel Activators Protect the N -Methyl- d -Aspartate–Induced Cerebral Vascular Dilation After Combined Hypoxia and Ischemia in Piglets

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Effects of D-cycloserine, a positive modulator of N-methyl-D-aspartate receptors, and ST 587, a putative alpha-1 adrenergic agonist, individually and in combination, on the non-delayed and delayed foraging behaviour of rats assessed in the radial arm maze

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Nontransportable Inhibitors Attenuate Reversal of Glutamate Uptake in Synaptosomes Following a Metabolic Insult

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A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder

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Ion Channel Diseases of the Central Nervous System

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Solar pruning of retinal rods in albino rainbow trout

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The different responses of rat glutamate transporter type 2 and its mutant (tyrosine 403 to histidine) activity to volatile anesthetics and activation of protein kinase C

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Differential expression of N-methyl-d-aspartate receptor subunit messenger ribonucleic acids and immunoreactivity in the rat neostriatum during postnatal development

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Glial‐derived arginine, the nitric oxide precursor, protects neurons from NMDA‐induced excitotoxicity

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Neuroprotective effects of MTEP, a selective mGluR5 antagonists and neuropeptide Y on the kainate-induced toxicity in primary neuronal cultures.

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Distribution of radiolabeled l-glutamate and d-aspartate from blood into peripheral tissues in naive rats: Significance for brain neuroprotection

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Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death

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Glutamate Receptor Binding in the Human Hippocampus and Adjacent Cortex During Development and Aging

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Preparation and characterization of PLGA nanospheres for the targeted delivery of NR2B-specific antisense oligonucleotides to the NMDA receptors in the brain

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Glia Modulate NMDA‐Mediated Signaling in Primary Cultures of Cerebellar Granule Cells

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Alzheimer’s Disease: From Molecular Mechanisms to Promising Therapeutic Strategies

Ivanova, A. V., Kutuzova, A. D., Kuzmichev, I., & Abakumov, M. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199444 · Cited by 33

Early changes in synaptic and intrinsic properties of dentate gyrus granule cells in a mouse model of Alzheimer's disease neuropathology and atypical effects of the cholinergic antagonist atropine

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Equine Estrogens Differentially Prevent Neuronal Cell Death Induced by Glutamate

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Isoflurane Enhances the Expression and Activity of Glutamate Transporter Type 3 in C6 Glioma Cells

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Dual mechanisms of Ca2+ increases elicited by N‐methyl‐ D ‐aspartate in immature and mature cultured cortical neurons

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Changes in astroglial GLT-1 expression after neural transplantation or stab wounds.

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Downregulation of nitric oxide in the brain of mice during their hypoxic preconditioning

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Selective mGluR1 Antagonist EMQMCM Inhibits the Kainate-Induced Excitotoxicity in Primary Neuronal Cultures and in the Rat Hippocampus

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Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells

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NMDA excitotoxicity and free radical generation in rat brain homogenates: Application of a chemiluminescence assay

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Fluid Percussion Brain Injury Exacerbates Glutamate-Induced Focal Damage in the Rat

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TsTx Toxin Isolated from Tityus serrulatus Scorpion Venom‐Induced Spontaneous Recurrent Seizures and Mossy Fiber Sprouting

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High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes

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Quantitative Analysis of Membrane Potentials

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Calcium homeostasis of acutely denervated and lesioned dentate gyrus in organotypic entorhino-hippocampal co-cultures

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The Selective Vulnerability of Retinal Ganglion Cells in Rat Chronic Ocular Hypertension Model at Early Phase

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How could N-Methyl-D-Aspartate Receptor Antagonists Lead to Excitation Instead of Inhibition?

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In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons

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Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain

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Detection of reactive oxygen species in primary cultures of cerebellar granule cells

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Hypoxia/Ischemia Induces Dephosphorylation of Rat Brain Neuromodulin/GAP‐43 In Vivo

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Chronic glutamate treatment selectively modulates AMPA RNA editing and ADAR expression and activity in primary cortical neurons

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AMP-activated protein kinase is involved in perfluorohexanesulfonate -induced apoptosis of neuronal cells

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Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension

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Stereoselective neuroprotection by novel 2,3-benzodiazepine non-competitive AMPA antagonists against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures

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KDI tripeptide of γ1 laminin protects rat dopaminergic neurons from 6‐OHDA induced toxicity

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Modulation of the gene expression of N-methyl-d-aspartate receptor NR2B subunit in the rat neostriatum by a single dose of specific antisense oligodeoxynucleotide

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Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection

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Oxidative Stress and Methylmercury‐Induced Neurotoxicity

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Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

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Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway

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Effects of methylprednisolone on the GABA- and glutamate-induced currents: Relevance to glucocorticoid-induced neurotoxicity and brain aging

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Astrocytes repress the neuronal expression of GLAST and GLT glutamate transporters in cultured hippocampal neurons from embryonic rats

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Sleep protects excitatory cortical circuits against oxidative damage

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Differential regulation of X-chromosome-linked inhibitor of apoptosis protein (XIAP) and caspase-3 by NMDA in developing hippocampal neurons; involvement of the mitochondrial pathway in NMDA-mediated neuronal survival

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Apoptosis and cytochrome c release in cerebellar granule cells.

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Functional effects of TrkA inhibition on system x C − -mediated glutamate release and cancer-induced bone pain

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Selective overexpression of γ1 laminin in astrocytes in amyotrophic lateral sclerosis indicates an involvement in ALS pathology

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Radiosynthesis and in vivo evaluation of [ 11 C]Ro‐647312: a novel NR1/2B subtype selective NMDA receptor radioligand

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Isoflurane decreases AMPA-induced dark cell degeneration and edematous damage of Purkinje neurons in the rat cerebellar slices

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Pathogenic mechanisms in ischemic damage: a computational study

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Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra

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Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia

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Is Encephalopathy a Mechanism to Renew Sulfate in Autism?

Seneff, S., Lauritzen, A., Davidson, R. M., & Lentz-Marino, L. (2013) · Entropy · doi:10.3390/e15010372 · Cited by 16

Stereoselective synthesis of azetidine-derived glutamate and aspartate analogues from chiral azetidin-3-ones

Burtoloso, A. C. B., & Correia, C. R. D. (2008) · Tetrahedron · doi:10.1016/j.tet.2008.08.001 · Cited by 16

Functional Organization of Dorsal Horn Interneurons

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Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration.

Iravani, M., Liu, L., Rose, S., & Jenner, P. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.033 · Cited by 15

REVIEW ■ : Physical Injury of Neurons: Important Roles for Sodium and Chloride Ions

Lucas, J. H., Emery, D. G., & ROSENBERG, L. J. (1997) · The Neuroscientist · doi:10.1177/107385849700300208 · Cited by 16

SYNTHESIS AND IN VITRO AND IN VIVO EVALUATION OF [11C]METHYL-BIII277CL FOR IMAGING THE PCP-BINDING SITE OF THE NMDA RECEPTOR BY PET

Kokic, M., Honer, M., Kessler, L. J., Grauert, M., Schubiger, P. A., & Ametamey, S. M. (2002) · Journal of Receptors and Signal Transduction · doi:10.1081/rrs-120014591 · Cited by 15

Maturation of channels and receptors: Consequences for excitability

Owens, D. F., & Kriegstein, A. R. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)45006-9 · Cited by 14

Insulin‐Like Growth Factor I Prevents the Development of Sensitivity to Kainate Neurotoxicity in Cerebellar Granule Cells

Leski, M. L., Valentine, S. L., Baer, J. D., & Coyle, J. T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751548.x · Cited by 15

Nicotine‐mediated neuroprotection of rat spinal networks against excitotoxicity

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[18F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging

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Astroglia and Obsessive Compulsive Disorder

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Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus

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The neuroprotective KDI domain of γ1‐laminin is a universal and potent inhibitor of ionotropic glutamate receptors

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AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex

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NMDA receptor mediated Ca2+ responses in neurons differentiated from p53−/− immortalized Murine neural stem cells

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Ethanol and the NMDA Receptor: Implications for Intoxication, Tolerance, Dependence, and Alcoholic Brain Damage

Lovinger, D. M. (1996) · Springer eBooks · doi:10.1007/978-3-642-80193-8_1 · Cited by 14

NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: An in vitro model for the study of neural precursor cell proliferation

Bunk, E. C., König, H., Bonner, H. P., Kirby, B. P., & Prehn, J. H. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.024 · Cited by 13

Peroxisome proliferator‐activated receptor‐γ coactivator‐1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X‐linked inhibitor of apoptosis protein

Mäkelä, J., Mudò, G., Pham, D. D., Liberto, V. D., Eriksson, O., Louhivuori, L. M., Bruelle, C., Soliymani, R., Baumann, M., Korhonen, L., et al. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13157 · Cited by 13

Glutamate agonist causes irreversible degeneration of inner hair cells

Hyodo, J., Hakuba, N., Hato, N., Takeda, S., Okada, M., Omotehara, Y., & Gyo, K. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32833017ce · Cited by 13

L‐type calcium channels reduce ROS generation in cerebellar granule cells following kainate exposure

Leski, M. L., Hassinger, L. C., Valentine, S. L., Baer, J. D., & Coyle, J. T. (2001) · Synapse · doi:10.1002/syn.10015 · Cited by 13

Behavioural effects in mice orally exposed to domoic acid or ibotenic acid are influenced by developmental stages and sex differences

Sasaki, T., Saito, H., Hiradate, Y., Hara, K., & Tanemura, K. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.04.080 · Cited by 13

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Desensitization of N-Methyl-D-aspartate Receptor Channels

Nakamichi, N., & Yoneda, Y. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj04007x4 · Cited by 12

Characterization of developing rat cortical neurons after epileptiform discharges

Jiang, Q., Wu, Y., Wang, J., Wu, X., Qin, J., & Jiang, Y. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.06.006 · Cited by 10

Soluble KDI domain of γ1 laminin protects adult hippocampus from excitotoxicity of kainic acid

Wikstén, M., Väänänen, A. J., Liebkind, R., Rauhala, P. V., & Liesi, P. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20158 · Cited by 12

Spinal Axonal Injury Transiently Elevates the Level of Metabotropic Glutamate Receptor 5, but Not 1, in Cord-Projection Central Neurons

Wang, Y., & Tseng, G. (2004) · Journal of Neurotrauma · doi:10.1089/089771504323004629 · Cited by 11

Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation

Sobieski, C. A., Warikoo, N., Shu, H., & Mennerick, S. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195520 · Cited by 11

Para -Substituted α-Phenyl- N - tert -butyl Nitrones: Spin-Trapping, Redox and Neuroprotective Properties

Deletraz, A., Tuccio, B., Roussel, J., Combes, M., Cohen‐Solal, C., Fabre, P., Trouillas, P., Vignes, M., Callizot, N., & Durand, G. (2020) · ACS Omega · doi:10.1021/acsomega.0c03907 · Cited by 11

Inhibition of mitochondrial function in astrocytes: implications for neuroprotection

Voloboueva, L. A., Suh, S. W., Swanson, R. A., & Giffard, R. G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.4634.x · Cited by 11

TSII toxin isolated from Tityus serrulatus scorpion venom: behavioral, electroencephalographic, and histopathologic studies

Sandoval, M. R. L., & Lebrun, I. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.006 · Cited by 11

Proteins Involved in the Trafficking and Functional Synaptic Expression of AMPA and KA Receptors

Rue, S. A. D. L., & Henley, J. M. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.97 · Cited by 10

Ca2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells

Brorson, J. R., Manzolillo, P. A., & Miller, R. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00187.1994 · Cited by 203

Ca 2+ influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes, Neurobiol. Dis. 9

Alberdi, E. M., Sánchez-gómez, M. V., Marino, A., & Matute, C. (2002)

Ca2+ Influx through AMPA or Kainate Receptors Alone Is Sufficient to Initiate Excitotoxicity in Cultured Oligodendrocytes

Alberdi, E. M., Sánchez‐Gómez, M. V., Marino, A., & Matute, C. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0457 · Cited by 119

Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity

Bosch, L. V. D., & Robberecht, W. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00371-3 · Cited by 51

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

Sánchez‐Gómez, M. V., & Matute, C. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0264 · Cited by 150