Chapter 34 Synaptic modulation by neurotrophic factors
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This chapter focuses on the recent results on synaptic modulation by neurotrophic factors and discusses their physiological implications. Several recent studies have indeed shown rapid synaptic modulation by a number of neurotrophic factors, including neurotrophins—a family of factors related to nerve growth factors (NGF)—as well as ciliary neurotrophic factor (CNTF)—a factor in the cytokine family known to promote the survival of a variety of neuronal populations. The effects of neurotrophins on synaptic currents can be accounted for by presynaptic actions of the factors—namely, a potentiation of transmitter secretion, either in the availability of transmitter containing vesicles or in the probability of vesicular exocytosis. The potential role of neurotrophins in regulating the maturation of synaptic functions is also addressed in cell culture. An important issue that remains to be addressed is the biological relevance of the synaptic modulation by neurotrophic factors observed in various in vitro preparations.
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BDNF influences neuronal plasticity by facilitating neurotransmitter release, increasing vesicular docking, enhancing glutamate-evoked post-synaptic responses and facilitating hippocampal and cortical long-term potentiation.
“BDNF influences neuronal plasticity by facilitating neurotransmitter release29, increasing vesicular docking, enhancing glutamate-evoked post-synaptic responses30 and facilitating hippocampal and cortical long-term potentiation31.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [29]
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- Authors
- Stoop, R., & Poo, M.
- Affiliations
- Columbia University (US)
- ORCID
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 1996
- Volume
- 109
- Pages
- 359-364
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1621681081
- Cited by
- 47
- References
- 42
- Citations by year
- 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2012: 3
- FWCI
- 5.51
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in brain research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- synaptic modulation, neurotrophic factors, neurotrophins, nerve growth factor, ciliary neurotrophic factor, presynaptic neurotransmitter release, synaptic vesicle exocytosis, synapse maturation, neuronal survival
- MeSH terms
- Animals, Brain, Cerebral Cortex, Nerve Growth Factors, Nerve Tissue Proteins, Neuromuscular Junction, Synapses, Long-Term Potentiation, Brain-Derived Neurotrophic Factor, Ciliary Neurotrophic Factor, Rats
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