The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Maladaptive striatal plasticity in l-DOPA-induced dyskinesia
Open accessAbstract
Dopamine (DA) replacement therapy with l-DOPA remains the most effective treatment for Parkinson’s disease, but causes dyskinesia (abnormal involuntary movements) in the vast majority of the patients. The basic mechanisms of l-DOPA-induced dyskinesia (LID) have become the object of intense research focusing on neurochemical and molecular adaptations in the striatum. Here we review this vast literature and highlight trends that converge into a unifying pathophysiological interpretation. We propose that the core molecular alteration of striatal neurons in LID consists in an inability to turn down supersensitive signaling responses downstream of DA D1 receptors (where supersensitivity is primarily caused by DA denervation). The sustained activation of intracellular signaling pathways induced by each dose of l-DOPA leads to abnormal cellular plasticity and high bioenergetic expenditure. The over-exploitation of signaling pathways and energy reserves during treatment impairs the ability of striatal neurons to dynamically gate cortically driven motor commands. LID thus exemplifies a disorder where ‘too much’ molecular plasticity leads to plasticity failure in the striatum.
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Cites
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Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
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BackgroundSelf-citationWhere Do You Think You Are Going? The NMDA-D1 Receptor Trap
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Striatal Akt/GSK3 signaling pathway in the development of L-Dopa-induced dyskinesias in MPTP monkeys
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Basal Ganglia Disorders Associated with Imbalances in the Striatal Striosome and Matrix Compartments
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MicroRNA-128 governs neuronal excitability and motor behavior in mice
Tan, C. L., Plotkin, J. L., Venø, M. T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O’Carroll, D., et al. (2013) · Science · doi:10.1126/science.1244193 · Cited by 301
Fieblinger, T., Graves, S. M., Sebel, L. E., Alcacer, C., Plotkin, J. L., Gertler, T. S., Chan, C. S., Heiman, M., Greengard, P., Cenci, M. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6316 · Cited by 295
Self-citationCatechol-O-Methyltransferase Inhibitors in Parkinson’s Disease
Müller, T. (2015) · Drugs · doi:10.1007/s40265-014-0343-0 · Cited by 190
Serotonin–dopamine interaction in the induction and maintenance of l-DOPA-induced dyskinesias
CARTA, M., CARLSSON, T., MUNOZ, A., KIRIK, D., & BJORKLUND, A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00922-9 · Cited by 131
Metadata
- Authors
- Cenci, M. A., & Konradi, C.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2010
- Volume
- 183
- Pages
- 209-233
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1799696262
- Cited by
- 216
- References
- 8
- FWCI
- 44.22
- Type
- book chapter
- Language
- en
- Open access
- green
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