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Cited by 125Hormonal and reproductive studiesProstate Cancer Treatment and ResearchUrinary Bladder and Prostate Research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Prostate size in hypogonadal men treated with a nonscrotal permeation-enhanced testosterone transdermal system

Wayne Meikle, A., Arver, Stefan, Dobs, Adrian S., Adolfsson, Jan, Sanders, Steven W., Middleton, Richard G., Stephenson, Robert A., Hoover, Donald R., Rajaram, Lakshiminaryan, Mazer, Norman A.·1997·Urology
DOI 10.1016/s0090-4295(96)00445-1
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Abstract

Objectives This study examined the effects of testosterone replacement using a nonscrotal testosterone transdermal (TTD) system on prostate size and prostate-specific antigen (PSA) levels in hypogonadal men.Methods As part of an open-label, multicenter study, prostate volume as measured by transrectal ultrasound and PSA were assessed in 29 hypogonadal men during treatment with intramuscular testosterone enanthate (+TE), followed by 8 weeks of androgen withdrawal (-T), and then during 1 year of therapy with Androderm Testosterone Transdermal System, a nonscrotal permeation-enhanced TTD system (+TTD).Results Mean prostate volume decreased significantly from the +TE period (17 g) compared with the -T period (14 g) (P < 0.001). Prostate volume increased significantly from the -T period compared with the +TTD period (18 g) (P < 0.001). Maximum prostate size, comparable to that measured during +TE (P = 0.125), was reached by month 3 of +TTD therapy; prostate volume did not increase further during the remaining 9 months of +TTD therapy. Prostate volume correlated with age (P < 0.01) during all three periods of observation (+TE: r = 0.69; -T: r = 0.64; and +TTD: r = 0.55). No patient developed symptomatic benign prostatic hyperplasia during the treatment period. PSA levels decreased during androgen withdrawal compared with levels measured during +TE treatment (P < 0.001) and rose with resumption of androgen therapy with TTD (P < 0.006). However, PSA levels during +TTD replacement remained significantly lower (P < 0.001) than during +TE replacement.Conclusions Physiologic testosterone replacement in hypogonadal men was achieved using the TTD system. Prostate size during therapy with TTD was comparable to that reported for normal men. In these men treated with TTD, PSA levels were also within the normal range.

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Crossref · 10.1016/s0090-4295(96)00445-1

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38 of 38 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Moore, 1944, Benign hypertrophy and carcinoma of the prostate. Occurrence and experimental production in animals, Surgery, 16, 152

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Metadata

Authors
Wayne Meikle, A., Arver, S., Dobs, A. S., Adolfsson, J., Sanders, S. W., Middleton, R. G., Stephenson, R. A., Hoover, D. R., Rajaram, L., & Mazer, N. A.
Affiliations
Karolinska University Hospital (SE)
ORCID
Venue
Urology
Publisher
Elsevier BV
Published
1997-02
Volume
49
Issue
2
Pages
191-196
ISSN
0090-4295 (ISSN-L)
DOI
10.1016/s0090-4295(96)00445-1
OpenAlex
W1980883512
Cited by
125
References
34
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
6.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Urology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r55dk043344-01, 5r01dk045760-04)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-43344, DK45760)
  • National Center for Research Resources (M01-RR 00064, M01RR000064)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
testosterone replacement therapy, hypogonadism, prostate volume, prostate-specific antigen, androgen withdrawal, testosterone enanthate, benign prostatic hyperplasia
MeSH terms
Administration, Cutaneous, Adult, Aged, Humans, Hypogonadism, Male, Middle Aged, Prostate, Testosterone, Prostate-Specific Antigen

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