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Cited by 335Hormonal and reproductive studiesProstate Cancer Treatment and ResearchUrinary Bladder and Prostate Research

Prostate volume in testosterone‐treated and untreated hypogonadal men in comparison to age‐matched normal controls

Behre, Hermann M., Bohmeyer, Jörg, Nieschlag, Eberhard·1994·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1994.tb03929.x
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Abstract

Summary: OBJECTIVE The potential use of testosterone preparations for substitution therapy for ageing men and for male contraception, In addition to the well established substitution therapy of male hypogonadism, make increased testosterone use likely. However, little clinical information is available on the effect of testosterone therapy on the prostate in hypogonadal men. DESIGN AND MEASUREMENTS In a controlled cross‐sectional study, prostate volume measured by transrectal ultrasonography, serum levels of prostate‐specific antigen (PSA) and sex hormones, and uroflow parameters were determined. PATIENTS Three groups of age‐matched men were enrolled in the study: 47 newly diagnosed hypogonadal men before testosterone treatment, 78 hypogonadal men with at least 6 months of effective testosterone therapy and 75 normal men. RESULTS Regression analysis revealed a significant positive correlation of prostate volume with age in normal men and testosterone‐treated hypogonadal men, whereas no significant correlation was detected in untreated hypogonadal men. Prostate volume was significantly lower in untreated hypogonadal men (12.2 (11.0–13.5) ml) (mean (95% confidence limits)) compared to both other groups. However, no significant difference in prostate volume was detected between testosterone‐treated hypogonadal men (21.3 (19.9–22.8) ml) and normal men (22.9 (21.4–24.4) ml). Similar results were obtained for PSA with comparable values in the testosterone‐treated hypogonadal men (0.98 (0.88–1.10) μg/l) and normal men (1.02 (0.91–1.14) μg/l), and significantly lower concentrations in the untreated hypogonadal men (0.64 (0.55–0.73) μg/l). No differences in uroflow parameters were detected between the three study groups. CONCLUSIONS Effective testosterone treatment of hypogonadal men results in prostate volume and prostate‐specific antigen levels comparable to age‐matched normal men. Therefore, testosterone‐induced prostate growth should not preclude hypogonadal men from testosterone substitution therapy.

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Crossref · 10.1111/j.1365-2265.1994.tb03929.x

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Authors
Behre, H. M., Bohmeyer, J., & Nieschlag, E.
Affiliations
University of Münster (DE)
Corresponding author
Nieschlag, Eberhard
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1994-03
Volume
40
Issue
3
Pages
341-349
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1994.tb03929.x
OpenAlex
W2110130030
Cited by
335
References
56
Citations by year
2025: 3 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 8
FWCI
8.79
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6029 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • World Health Organization
  • Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
testosterone replacement therapy, hypogonadism, prostate volume, prostate-specific antigen, male hypogonadism, prostate growth, uroflowmetry, older men, male contraception
MeSH terms
Adult, Age Factors, Aging, Anthropometry, Cross-Sectional Studies, Humans, Hypogonadism, Male, Prostate, Reference Values, Testosterone, Prostate-Specific Antigen

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