Mitotane (1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane) metabolism in perfusion studies with dog adrenal glands
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Active metabolites produced by adrenal mitochondria covalently bind to mitochondrial proteins hypothesized to inhibit mitochondrial respiration.
“Active metabolites produced by adrenal mitochondria, in turn, covalently bind to mitochondrial proteins hypothesized to inhibit mitochondrial respiration (285).”
From Adrenocortical carcinoma (2014) · cites this paper as [285]
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Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
Metabolic Activation and Binding of Mitotane in Adrenal Cortex Homogenates
Cai, W., Counsell, R. E., Djanegara, T., SCHTEINGART, D. E., Sinsheimer, J. E., & Wotring, L. L. (1995) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600840203 · Cited by 56 · see citing works
Self-citationSchteingart, D. E., Sinsheimer, J. E., Counsell, R. E., Abrams, G. D., McClellan, N., Djanegara, T., Hines, J., Ruangwises, N., Benitez, R., & Wotring, L. L. (1993) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00685036 · Cited by 38 · see citing works
Self-citationCai, W., Benitez, R., Counsell, R. E., Djanegara, T., SCHTEINGART, D. E., Sinsheimer, J. E., & Wotring, L. L. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00028-x · Cited by 36 · see citing works
Self-citationSCHTEINGART, D. E., Sinsheimer, J. E., Benitez, R. S., Homan, D. F., Johnson, T. D., & Counsell, R. E. (2012) · PubMed · Cited by 12 · see citing works
Self-citationSynthesis of β‐3H‐mitotane for use in a rapid assay for mitotane metabolism
Piñeiro-Sánchez, M. L., Vaz, A. D. N., Counsell, R. E., et al. (1995) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.2580360204 · Cited by 6 · see citing works
Sinsheimer, J. E., Counsell, R. E., Cai, W., et al. (1996) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/0731-7085(96)01729-3 · Cited by 4 · see citing works
Self-citationSCHTEINGART, D. E. (2012) · Yearbook of Endocrinology · doi:10.1016/j.yend.2012.05.057 · Cited by 3 · see citing works
- Authors
- Sinsheimer, J. E., & Freeman, C. J.
- ORCID
- Freeman, C J
- Venue
- Drug Metabolism and Disposition
- Publisher
- Elsevier BV
- Published
- 1987-03
- Volume
- 15
- Issue
- 2
- Pages
- 267-269
- ISSN
- 0090-9556 (ISSN-L)
- OpenAlex
- W2414093173
- Cited by
- 9
- References
- 0
- Citations by year
- 2020: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Metabolism and Disposition (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Funders
- National Institutes of Health (5r01ca037794-06)
- National Cancer Institute (R01 CA 37794)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- mitotane, drug metabolism, adrenal gland, adrenal cortex
- MeSH terms
- Adrenal Glands, Animals, Biotransformation, Chromatography, High Pressure Liquid, Chromatography, Thin Layer, DDT, Dogs, Hydroxylation, Mitotane, Perfusion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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