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Cited by 344Phytochemicals and Medicinal PlantsMedicinal Plants and Bioactive CompoundsBiofield Effects and Biophysics

The DOI matches its Crossref record; 45 of the 48 references it cites were found in a registry or an index.

Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress

Bhattacharya, S.K, Muruganandam, A.V·2003·Pharmacology Biochemistry and Behavior
DOI 10.1016/s0091-3057(03)00110-2
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Abstract

Withania somnifera (WS) Dunal is classified in Ayurveda, the ancient Hindu system of medicine, as a rasayana, a group of plant-derived drugs reputed to promote physical and mental health, augment resistance of the body against disease and diverse adverse environmental factors, revitalise the body in debilitated conditions and increase longevity. These attributes are remarkably similar to the properties ascribed to adaptogens like Panax ginseng (PG) in contemporary medicine. As such, the adaptogenic activity of a standardised extract of WS roots was investigated against a rat model of chronic stress (CS). The stress procedure was mild, unpredictable footshock, administered once daily for 21 days to adult male Wistar rats. CS induced significant hyperglycaemia, glucose intolerance, increase in plasma corticosterone levels, gastric ulcerations, male sexual dysfunction, cognitive deficits, immunosuppression and mental depression. These CS induced perturbations were attenuated by WS (25 and 50 mg/kg po) and by PG (100 mg/kg po), administered 1 h before footshock for 21 days. The results indicate that WS, like PG, has significant antistress adaptogenic activity, confirming the clinical use of the plant in Ayurveda.

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Research works printed but not linked: 3

  1. Bhattacharya, 1995, Effect of Mentat, a herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats, Fitoterapia, LXVI, 216
  2. Chrousos, 1992, The concept of stress and stress system disorders, JAMA, 267, 1244, 10.1001/jama.267.9.1244 · DOI · Paper page
  3. Muruganandam, 2002, Effect of polyherbal formulation, Eumil, on chronic stress-induced homoeostatic perturbations in rats, Indian J. Exp. Biol., 40, 1151

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Metadata

Authors
Bhattacharya, S. K., & Muruganandam, A. V.
Affiliations
University of Calcutta (IN)
Corresponding author
Muruganandam, A.V
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2003-06
Volume
75
Issue
3
Pages
547-555
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/s0091-3057(03)00110-2
OpenAlex
W2138681644
Cited by
344
References
48
Citations by year
2026: 13 · 2025: 11 · 2024: 18 · 2023: 19 · 2022: 28 · 2021: 17 · 2020: 15 · 2019: 16 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 15 · 2014: 24 · 2013: 22 · 2012: 16
FWCI
10.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
  • Health Sciences › Medicine › Complementary and alternative medicine › Biofield Effects and Biophysics
Keywords
Withania somnifera, adaptogenic activity, chronic stress, Panax ginseng, Ayurveda, Rasayana, hyperglycemia, impaired glucose tolerance, corticosterone, gastric ulcer, male sexual dysfunction, cognitive impairment, immunosuppression, depression, root extract
MeSH terms
Animals, Avoidance Learning, Chronic Disease, Disease Models, Animal, Male, Medicine, Ayurvedic, Phytotherapy, Plant Extracts, Stress, Physiological, Rats, Wistar, Plant Roots, Withania, Rats

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