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Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination
Abstract
Alcoholics and controls given ethanol (1.2 g/kg body weight) were analyzed for blood and breath acetaldehyde using the more sensitive and reliable semicarbazide method. The acetaldehyde levels in controls were almost undetectable (less than 2 microM), but were found to be elevated (10--10 microM) in 6 of 8 alcoholics. Breath acetaldehyde and blood acetaldehyde co-fluctuated during the experiments. Fructose infusion transiently increased blood acetaldehyde, but only in 4 of the alcoholics. The apparent discrepancy between our finding and the simultaneously reported low acetaldehyde level in alcoholics (Eriksson and Peachy, this volume) may be explained by the different status of the alcoholics tested. Our alcoholics were tested on the day after hospital admission and eliminated ethanol 5% faster than controls. It is suggested that elevated blood acetaldehyde occurs regularly after interrupted drinking in heavy alcohol abusers with fast ethanol elimination, possibly combined with reduced liver aldehyde dehydrogenase activity, but that the phenomenon may rapidly disappear upon abstinence and hospital treatment, which reduces disturbances in hepatic functions and the ethanol elimination rate.
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“In human ALD, blood acetaldehyde level is significantly upregulated and its increase parallels the elevation of ethanol concentration [140,141,142,143].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [142]
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Research works printed but not linked: 17
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Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324
Metadata
- Authors
- Lindros, K. O., Stowell, A., Pikkarainen, P., & Salaspuro, M.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Lindros, Kai O.
- ORCID
- Salaspuro, Mikko
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1980-01
- Volume
- 13
- Pages
- 119-124
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2038506905
- Cited by
- 120
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 2 · 2012: 2
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- blood acetaldehyde, alcoholism, ethanol elimination rate, fructose infusion, aldehyde dehydrogenase, liver function, alcohol abstinence
- MeSH terms
- Acetaldehyde, Adult, Ethanol, Alcoholism, Breath Tests, Humans, Metabolic Clearance Rate, Middle Aged
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