High Blood Acetaldehyde Levels after Ethanol Administration: Difference between Alcoholic and Nonalcoholic Subjects
Abstract
Blood actaldehyde and ethanol levels were measured in 11 subjects, six with chronic alcholoism and five nonalcholic controls, after alcohol had been given intravenously. Despite a progressive fall in blood ethanol over a range of 54 to 33 mM/acetaldehyde did not decrease in any of the 11 subjects. The mean acetaldehyde plateau level was significantly (p less than 0.001) higher in alcoholic (42.7 plus or minus 1.2 mum) than in nonalcoholic (26.5 plus or minus 1.5 mum) subjects. When the mean blood ethanol concentration reached 24 mM,the acetaldehyde plateau ended abruptly in each subject. The ethanol concentration at which this fall of blood acetaldehyde occurred suggests desaturation of an ethanol oxidizing system other than alcohol dehydrogenase and indicates that at high ethanol blood levels, such a system contributes to ethanol oxidation. The highet acetaldehyde levels in alcholism may result from both greater activity of this system and mitochondrial damage, and could contribut to the neurologic, hepatic and cardiac complications of alcoholism.
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In human ALD, blood acetaldehyde level is significantly upregulated and its increase parallels the elevation of ethanol concentration.
“In human ALD, blood acetaldehyde level is significantly upregulated and its increase parallels the elevation of ethanol concentration [140,141,142,143].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [141]
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Malouf, R., & Brust, J. C. M. (1985) · Annals of Neurology · doi:10.1002/ana.410170502 · Cited by 286 · see citing works
Mechanism of ethanol induced hepatic injury
Lieber, C. S. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90032-w · Cited by 168 · see citing works
Self-citationBehavioral and physiological effects of ethanol in high-risk and control children: a pilot study
Behar, D., Berg, C. J., Rapoport, J. L., Nelson, W., Linnoila, M., Cohen, M., Bozevich, C., & Marshall, T. (1983) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1983.tb05495.x · Cited by 87 · see citing works
Hartley, D. P., & Petersen, D. R. (1997) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03764.x · Cited by 30 · see citing works
- Authors
- Korsten, M. A., Matsuzaki, S., Feinman, L., & Lieber, C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1975-02-20
- Volume
- 292
- Issue
- 8
- Pages
- 386-389
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2026635928
- Cited by
- 518
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 27.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- blood acetaldehyde, ethanol oxidation, chronic alcoholism, alcohol dehydrogenase, mitochondrial damage
- MeSH terms
- Acetaldehyde, Adult, Ethanol, Alcoholism, Chromatography, Chromatography, Gas, Humans, Injections, Intravenous, Male, Middle Aged, Oxidation-Reduction, Time Factors
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