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Cited by 226Cannabis and Cannabinoid ResearchSchizophrenia research and treatmentPsychedelics and Drug Studies

The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.

Towards a Cannabinoid Hypothesis of Schizophrenia: Cognitive Impairments Due to Dysregulation of the Endogenous Cannabinoid System

Emrich, Hinderk M, Leweke, F.Markus, Schneider, Udo·1997·Pharmacology Biochemistry and Behavior
DOI 10.1016/s0091-3057(96)00426-1
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Abstract

Cognitive impairments during psychotic episodes are assumed to be caused not only by one single putative classical neurotransmitter dysfunction but also by an impaired equilibrium of the interaction between different neurobiological generators of cognitive processes. Herein, the perceptual abnormalities induced by psychotogenic agents play a major role as tools for the understanding of model psychoses. The recently discovered cannabinoid receptor system with its endogenous ligand anandamide can be regarded as an extremely relevant regulator system, a dysfunctionality of which may explain at least one subtype of endogenous psychoses. Neuropsychological results (three-dimensional inversion illusion) in delta 9-tetrahydrocannabinol-intoxicated normal volunteers exhibit strong similarities with data acquired from patients suffering from productive schizophrenic psychoses, regarding disturbances in internal regulation of perceptual processes. The relevance of this finding to a general cognitive dysfunction concept of schizophrenic psychosis is discussed.

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Crossref · 10.1016/s0091-3057(96)00426-1

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Citations

Cites

Research works printed but not linked: 1

  1. Schröder, 1993, Diskrete motorische und sensorische Störungen (neurologische soft signs) im Akutverlauf endogener Psychosen, Z. Klin. Psychol. Psychopathol. Psychother., 41, 190

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Metadata

Authors
Emrich, H. M., Leweke, F. M., & Schneider, U.
Affiliations
Medizinische Hochschule Hannover (DE)
Corresponding author
Emrich, Hinderk M
ORCID
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1997-04
Volume
56
Issue
4
Pages
803-807
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/s0091-3057(96)00426-1
OpenAlex
W1986173065
Cited by
226
References
35
Citations by year
2025: 2 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 16 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 8
FWCI
5.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords
schizophrenia, endocannabinoid system, anandamide, cognitive impairment, perceptual disorders, cannabinoid receptors, psychosis
MeSH terms
Adult, Cannabinoids, Depth Perception, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Receptors, Drug, Schizophrenia, Schizophrenic Psychology, Vision, Binocular, Receptors, Cannabinoid

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