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Cited by 12Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionNeuroscience and Neuropharmacology Research

Effects of antidepressants in rats trained to discriminate the beta-2 adrenergic agonist clenbuterol

Makhay, Malath M, O’Donnell, James M·1999·Pharmacology Biochemistry and Behavior
DOI 10.1016/s0091-3057(98)00266-4
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Abstract

The ability of indirectly acting agonists such as norepinephrine uptake inhibitors, serotonin reuptake inhibitors, and atypical antidepressants to substitute for clenbuterol, a beta-2 adrenergic agonist, was examined in rats trained to discriminate 0.03 mg/kg clenbuterol and saline using a fixed-ratio 10 (FR 10) schedule with water reinforcement. The beta-2 selective adrenergic agonist clenbuterol produced an orderly dose-response relationship, and its discriminative stimulus effects were antagonized by the beta-adrenergic antagonist propranolol. It was found that the effects of tricyclic antidepressants and selective norepinephrine uptake inhibitors did not generalize to the discriminative stimulus effects of clenbuterol, with the exception of high doses of protriptyline. Moreover, compounds from other drug classes, including fluoxetine and phenelzine, did not substitute for clenbuterol. Atypical antidepressants, such as trazodone, rolipram, and bupropion also did not engender drug-appropriate responding. Prenalterol and dobutamine, both purported to be beta-1 adrenergic receptor agonists, partially substituted for clenbuterol, but at relatively high doses. The present results show that the antidepressants tested do not share discriminative stimulus effects with clenbuterol, a beta-2 adrenergic agonist.

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Crossref · 10.1016/s0091-3057(98)00266-4

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  • α3β4-containing nAChRs are believed to play a major role in nicotine-evoked NE release from the hippocampus.

    “α3β4-containing nAChRs are believed to play a major role in nicotine-evoked NE release from the hippocampus [220, 221].”

    From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [220]

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Authors
Makhay, M. M., & O’Donnell, J. M.
Affiliations
Louisiana State University (US)
Corresponding author
Makhay, Malath M
ORCID
O’Donnell, James M
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1999-06
Volume
63
Issue
2
Pages
319-324
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/s0091-3057(98)00266-4
OpenAlex
W2078982829
Cited by
10
References
36
Citations by year
2017: 1
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
clenbuterol, beta2-adrenergic agonists, antidepressants, discriminative stimulus effects, drug substitution, propranolol, tricyclic antidepressants, selective norepinephrine reuptake inhibitors, atypical antidepressants, beta-adrenoceptor antagonism, prenalterol, dobutamine
MeSH terms
Adrenergic beta-Agonists, Animals, Antidepressive Agents, Antidepressive Agents, Tricyclic, Clenbuterol, Conditioning, Operant, Discrimination Learning, Male, Receptors, Adrenergic, beta, Rats, Sprague-Dawley, Rats

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