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Cited by 281Asthma and respiratory diseasesIL-33, ST2, and ILC PathwaysAllergic Rhinitis and Sensitization

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma

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Shimbara, Ayako, Christodoulopoulos, Pota, Soussi-Gounni, Abdelilah, Olivenstein, Ronald, Nakamura, Yutaka, Levitt, Roy C., Nicolaides, Nicholas C., Holroyd, Kenneth J., Tsicopoulos, Anne, Lafitte, Jean-Jacques, Wallaert, Benoit, Hamid, Qutayba A.·2000·Journal of Allergy and Clinical Immunology
DOI 10.1016/s0091-6749(00)90185-4
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Abstract

Background Bronchial asthma is a chronic inflammatory disease associated with genetic components. Recently IL-9 has been reported as a candidate gene for asthma and to be associated with bronchial hyperresponsiveness and elevated levels of total serum IgE. Objective To investigate the contribution of IL-9 to the pathogenesis of asthma, we examined the expression of IL-9 and its receptor (IL-9R) in bronchial tissue from subjects with atopic asthma (n = 10), chronic bronchitis (n = 11), and sarcoidosis (n = 9) and from atopic (n = 7) and nonatopic (n = 10) healthy control subjects. Methods Bronchial biopsy specimens were examined for the presence of IL-9 and IL-9R protein and messenger RNA (mRNA) by immunocytochemistry and in situ hybridization, respectively. To phenotype the cells expressing IL-9 in asthmatic tissue, combined in situ hybridization and immunocytochemistry was also performed. Results There was a highly significant difference (P <.001) in the expression of IL-9 mRNA in asthmatic airways (20.6 +/- 4.0 cells/mm of basement membrane) compared with chronic bronchitis (5.6 +/- 4.4), sarcoidosis (2.5 +/- 1.8), atopic control subjects (7.7 +/- 2.2), and healthy control subjects (2.7 +/- 2.3). The number of IL-9 immunoreactive cells was also greater in asthmatic patients compared with the other groups (P <.05). Although the level of IL-9R mRNA expression did not differ in any of the groups (P >.05), IL-9R immunoreactivity was significantly higher in asthmatic compared with control subjects. Furthermore, IL-9 mRNA expression levels were also significantly correlated with FEV(1) (P <.05) and the airway responsiveness to methacholine producing a 20% fall in FEV(1) (P <. 01). The cells expressing IL-9 mRNA in asthmatic tissue were CD3(+) lymphocytes (68%), major basic protein(+) eosinophils (16%), and elastase(+) neutrophils (8%). Conclusion The results of this study demonstrate the potential of IL-9 to be a marker for atopic asthma and furthermore suggest an important role for this cytokine in the pathophysiologic mechanisms of this disease.

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Authors
Shimbara, A., Christodoulopoulos, P., Soussi-Gounni, A., Olivenstein, R., Nakamura, Y., Levitt, R. C., Nicolaides, N. C., Holroyd, K. J., Tsicopoulos, A., Lafitte, J.-J., Wallaert, B., & Hamid, Q. A.
Affiliations
  • McGill University (CA)
  • Inserm (FR)
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2000-01
Volume
105
Issue
1
Pages
108-115
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/s0091-6749(00)90185-4
OpenAlex
W2090021858
Cited by
281
References
38
Citations by year
2026: 1 · 2025: 7 · 2024: 8 · 2023: 3 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 14 · 2016: 12 · 2015: 17 · 2014: 7 · 2013: 15 · 2012: 16
FWCI
11.25
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords
IL-9, IL-9 receptor, asthma, allergic asthma, chronic bronchitis, sarcoidosis, airway inflammation, eosinophils, neutrophils, CD3+ T cells, airway hyperresponsiveness, methacholine challenge, FEV1, candidate genes, cytokine expression, lung disease biomarkers
MeSH terms
Adult, Asthma, Bronchi, Bronchial Diseases, Bronchitis, Chronic Disease, Female, Humans, Hypersensitivity, Male, Reference Values, RNA, Messenger, Sarcoidosis, Interleukin-9, Receptors, Interleukin, Receptors, Interleukin-9

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