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Studies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing patients with symptomatic from patients with asymptomatic allergy to common aeroallergens
Abstract
Background The detection of specific IgE antibodies to environmental allergens does not always coincide with a diagnosis of clinically evident allergic disease, because some patients with positive skin and/or in vitro test results have no symptoms related to the allergen or allergens that induced the antibodies. Objective In a multicenter study the optimal cutoff values for specific IgE antibody levels and skin test results that could discriminate between patients with symptomatic and those with asymptomatic allergy were determined. Methods IgE antibodies specific for a panel of common aeroallergens were assayed with the Pharmacia CAP System (Pharmacia, Uppsala, Sweden) in two groups of patients, a group of 267 patients with symptomatic allergy and a group of 232 with asymptomatic allergy--both with positive skin prick test results--and in a group of 243 healthy, nonallergic control subjects. The cutoff values were established by receiver operating characteristic analysis. Results A significantly higher mean specific IgE antibody value was found in patients with symptomatic allergy compared with patients with asymptomatic allergy (p Conclusions Cutoff values for specific serum IgE antibody levels are likely to be useful in clinical practice to distinguish symptomatic from asymptomatic allergy in patients with positive skin test results.
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“Consistent with published data,19 the majority of the allergen-specific IgEs were more prevalent among those who reported allergy-related outcomes than among asymptomatic individuals.”
From Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005-2006 (2011) · cites this paper as [19]
In the citing paper
“the presence of allergen-specific antibodies does not necessarily mean that a person has clinically relevant symptoms when exposed to an allergen”
From Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005-2006 (2011) · cites this paper as [19]
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Research works printed but not linked: 19
- Executive Committee of the American Academy of Allergy and Immunology, 1992, The use of in vitro tests for IgE antibody in the specific diagnosis of IgE-mediated disorders and in the formulation of allergen immunotherapy [Position statement], J ALLERGY CLIN IMMUNOL, 90, 263, 10.1016/0091-6749(92)90081-C · DOI
- Ewan, 1990, Evaluation of a capsulated hydrophilic carrier polymer (the immuno CAP) for measurement of specific IgE antibodies, Allergy, 45, 22, 10.1111/j.1398-9995.1990.tb01080.x · DOI
- Bousquet, 1990, Comparison between RAST and Pharmacia CAP System, a new automated specific IgE assay, J ALLERGY CLIN IMMUNOL, 85, 1039, 10.1016/0091-6749(90)90048-9 · DOI
- Pastorello, 1991, A multicentric study on sensitivity and specificity of a new in vitro test for measurement of IgE antibodies, Ann Allergy, 67, 365
- Eriksson, 1990, Allergy screening with PhadiatopR and CAP PhadiatopR in combination with a questionnaire in adults with asthma and rhinitis, Allergy, 45, 285, 10.1111/j.1398-9995.1990.tb00497.x · DOI
- Holgersson, 1985, The precision of skin prick test with Phazet™, the Osterballe needle and the bifurcated needle, Allergy, 40, 64
- 1989, Skin tests used in type I allergy testing. Position paper of the European Academy of Allergology and Clinical Immunology, Allergy, 44, 27
- McNeil, 1984, Statistical approaches to the analysis of receiver operating characteristic (ROC) curves, Med Decis Making, 4, 137, 10.1177/0272989X8400400203 · DOI
- Gerhardt, 1986, Evaluation of test data from clinical studies. I. Terminology, graphic interpretation, diagnostic strategies and selection of sample groups, Scand J Clin Lab Invest, 46, 5
- Lindblad, 1961, The incidence of positive intradermal reactions and the demonstration of skin sensitizing antibody to extracts of ragweed and house dust in humans without history of rhinitis or asthma, J Allergy, 32, 392, 10.1016/0021-8707(61)90016-8 · DOI
- Chambers, 1958, The incidence of subsequent ragweed pollinosis in symptom-free persons having positive reactions to ragweed-pollen extract, J Allergy, 29, 249, 10.1016/0021-8707(58)90009-1 · DOI
- Hagy, 1976, Risk factors for developing asthma and allergic rhinitis, J ALLERGY CLIN IMMUNOL, 58, 330, 10.1016/0091-6749(76)90139-1 · DOI
- Horak, 1985, Manifestation of allergic rhinitis in latent-sensitized patients. A prospective study, Arch Otorhinolaryngol, 242, 224, 10.1007/BF00453546 · DOI
- Pastorello, 1992, Clinical evaluation of CAP System and RAST in the measurement of specific IgE, Allergy, 47, 463, 10.1111/j.1398-9995.1992.tb00665.x · DOI
- Ollier, 1989, Skin prick test preparation of Dermatophagoides pteronyssinus for prediction of a positive response to provocation testing, Clin Exp Allergy, 19, 457, 10.1111/j.1365-2222.1989.tb02414.x · DOI
- de Blay, 1993, Receiver Operating Characteristic analysis: a useful method for a comparison of the clinical relevance of two in vitro IgE tests, J ALLERGY CLIN IMMUNOL, 92, 255, 10.1016/0091-6749(93)90169-G · DOI
- Williams, 1992, Comparison of skin testing and three in vitro assays for specific IgE in the clinical evaluation of immediate hypersensitivity, Ann Allergy, 68, 35
- Berg, 1974, Allergy diagnosis with the radioallergsorbent test: a comparison with the results of skin and provocation tests in an unselected group of children with asthma and hay fever, J ALLERGY CLIN IMMUNOL, 54, 209, 10.1016/0091-6749(74)90063-3 · DOI
- American Academy of Allergy and Immunology, 1986, The remote practice of allergy [Position statement], J ALLERGY CLIN IMMUNOL, 77, 651, 10.1016/0091-6749(86)90403-3 · DOI
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Self-citation
Metadata
- Authors
- Pastorello, E. A., Incorvaia, C., Ortolani, C., Bonini, S., Canonica, G. W., Romagnani, S., Tursi, A., & Zanussi, C.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 96
- Issue
- 5
- Pages
- 580-587
- ISSN
- 0091-6749
- Cited by
- 137
- References
- 0
- Language
- en
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- Pastorello, E. A., Incorvaia, C., Ortolani, C., Bonini, S., Canonica, G. W., Romagnani, S., Tursi, A., & Zanussi, C. (1995). Studies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing patients with symptomatic from patients with asymptomatic allergy to common aeroallergens. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/s0091-6749(95)70255-5
