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Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors
Open accessAbstract
Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex. Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone. While Sema3A binding to NP-1 does not alter nonneuronal cell morphology, Sema3A interaction with NP-1/Plex 1 complexes induces adherent cells to round up. Expression of a dominant-negative Plex 1 in sensory neurons blocks Sema3A-induced growth cone collapse. Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes.
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Metadata
- Authors
- Takahashi, T., Fournier, A., Nakamura, F., Wang, L.-H., Murakami, Y., Kalb, R. G., Fujisawa, H., & Strittmatter, S. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 99
- Issue
- 1
- Pages
- 59-69
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2047166961
- Cited by
- 817
- References
- 0
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Takahashi, T., Fournier, A., Nakamura, F., Wang, L.-H., Murakami, Y., Kalb, R. G., Fujisawa, H., & Strittmatter, S. M. (1999). Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors. Cell. https://doi.org/10.1016/s0092-8674(00)80062-8
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