Semaphorins and their receptors in immune cell interactions
Abstract
Semaphorins are newcomers to the growing panoply of immunoregulatory proteins. Members of this family were originally identified as proteins that provide axonal guidance cues during neuronal development. However, accumulating evidence indicates that several semaphorins, called 'immune semaphorins', are crucial to various phases of the immune response, from initiation to terminal inflammatory processes. Extensive studies of immune semaphorins have shown not only differences but also parallels in semaphorin functions among physiologically distinct systems, providing unexpected but meaningful insights into the biological activities of this protein family. Here we review the present knowledge of the function of semaphorins and their receptors in the immune system, including the most recent advances in this field.
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Semaphorins are a large family of glycoproteins, membrane-bound and soluble, found in a wide range of tissues, involved in immune response, organogenesis, cardiovascular development, and tumor progression.
“Semaphorins comprise a large family of glycoproteins which are not only membrane-bound but also exist as soluble forms that are found in a wide range of tissues and shown to be involved in diverse biological processes such as immune response, organogenesis, cardiovascular development, and tumor progression [172, 173].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [173]
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- Authors
- Suzuki, K., Kumanogoh, A., & Kikutani, H.
- Affiliations
- Japan Science and Technology Agency (JP)
- Immunology Frontier Research Center, The University of Osaka (JP)
- Corresponding author
- Kikutani, Hitoshi
- Venue
- Nature Immunology
- Published
- 2007-12-17
- Volume
- 9
- Issue
- 1
- Pages
- 17-23
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2055510343
- Cited by
- 400
- References
- 84
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 12 · 2023: 18 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 17 · 2018: 18 · 2017: 21 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 21 · 2012: 94
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- semaphorins, semaphorin receptors, immune cell interactions, immune regulation, axon guidance, inflammation, immune response initiation
- MeSH terms
- Animals, B-Lymphocytes, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunity, Cellular, Inflammation, Lymphocyte Activation, T-Lymphocytes, Signal Transduction, Antigens, CD, Semaphorins, Mice, GPI-Linked Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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