Cited by 400Axon Guidance and Neuronal SignalingPhagocytosis and Immune RegulationChemokine receptors and signaling

Semaphorins and their receptors in immune cell interactions

Suzuki, Kazuhiro, Kumanogoh, Atsushi, Kikutani, Hitoshi·2008·Nature Immunology

Abstract

Semaphorins are newcomers to the growing panoply of immunoregulatory proteins. Members of this family were originally identified as proteins that provide axonal guidance cues during neuronal development. However, accumulating evidence indicates that several semaphorins, called 'immune semaphorins', are crucial to various phases of the immune response, from initiation to terminal inflammatory processes. Extensive studies of immune semaphorins have shown not only differences but also parallels in semaphorin functions among physiologically distinct systems, providing unexpected but meaningful insights into the biological activities of this protein family. Here we review the present knowledge of the function of semaphorins and their receptors in the immune system, including the most recent advances in this field.

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Crossref · 10.1038/ni1553

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  • Semaphorins are a large family of glycoproteins, membrane-bound and soluble, found in a wide range of tissues, involved in immune response, organogenesis, cardiovascular development, and tumor progression.

    “Semaphorins comprise a large family of glycoproteins which are not only membrane-bound but also exist as soluble forms that are found in a wide range of tissues and shown to be involved in diverse biological processes such as immune response, organogenesis, cardiovascular development, and tumor progression [172, 173].”

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Authors
Suzuki, K., Kumanogoh, A., & Kikutani, H.
Affiliations
  • Japan Science and Technology Agency (JP)
  • Immunology Frontier Research Center, The University of Osaka (JP)
Corresponding author
Kikutani, Hitoshi
Venue
Nature Immunology
Published
2007-12-17
Volume
9
Issue
1
Pages
17-23
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W2055510343
Cited by
400
References
84
Citations by year
2026: 13 · 2025: 14 · 2024: 12 · 2023: 18 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 17 · 2018: 18 · 2017: 21 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 21 · 2012: 94
FWCI
1.64
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
semaphorins, semaphorin receptors, immune cell interactions, immune regulation, axon guidance, inflammation, immune response initiation
MeSH terms
Animals, B-Lymphocytes, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunity, Cellular, Inflammation, Lymphocyte Activation, T-Lymphocytes, Signal Transduction, Antigens, CD, Semaphorins, Mice, GPI-Linked Proteins

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