The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
Open accessAbstract
The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase. This rapidly induced gene encodes an enzyme that associates with the proteasome and increases its proteolytic activity. This regulated proteolysis is essential for long-term facilitation. Inhibiting the expression or function of the hydrolase blocks induction of long-term but not short-term facilitation. We suggest that the enhanced proteasome activity increases degradation of substrates that normally inhibit long-term facilitation. Thus, through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage.
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How Proteolysis Drives the Cell Cycle
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Genetic dissection of consolidated memory in Drosophila
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Self-citationDale, N., Kandel, E., & Schacher, S. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-07-02232.1987 · Cited by 118
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Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Self-citationThe 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
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Cognitive Neuroscience and the Study of Memory
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Self-citationThe Molecular and Systems Biology of Memory
Kandel, E. R., Dudai, Y., & Mayford, M. R. (2014) · Cell · doi:10.1016/j.cell.2014.03.001 · Cited by 1,134
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Metadata
- Authors
- Hegde, A. N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D. G., Martin, K. C., Kandel, E. R., & Schwartz, J. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-04
- Volume
- 89
- Issue
- 1
- Pages
- 115-126
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2147065485
- Cited by
- 359
- References
- 5
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia. https://app.cochat.ai/papers/10.1016/s0092-8674(00)80188-9
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- Hegde, A. N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D. G., Martin, K. C., Kandel, E. R., & Schwartz, J. H. (1997). Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia. Cell. https://doi.org/10.1016/s0092-8674(00)80188-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
