Cited by 1,134Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

The Molecular and Systems Biology of Memory

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Kandel, Eric R., Dudai, Yadin, Mayford, Mark R.·2014·Cell

Abstract

Learning and memory are two of the most magical capabilities of our mind. Learning is the biological process of acquiring new knowledge about the world, and memory is the process of retaining and reconstructing that knowledge over time. Most of our knowledge of the world and most of our skills are not innate but learned. Thus, we are who we are in large part because of what we have learned and what we remember and forget. In this Review, we examine the molecular, cellular, and circuit mechanisms that underlie how memories are made, stored, retrieved, and lost.

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Crossref · 10.1016/j.cell.2014.03.001

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  • Synaptic plasticity changes can be short-lived or long-term.

    “These changes can be short-lived, resulting in a more dynamic synaptic state, or long-term, resulting in a change in synaptic efficacy that can last for several months if not longer (Kandel et al., 2014).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Kandel et al., 2014

  • Within the dorsal horn, learning-related genes included both broadly expressed genes such as Camk2a (CAMK2α) and cell type-specific genes such as Prkcg (PKCγ).

    “Within the dorsal horn, this included both broadly expressed genes such as Camk2a (CAMK2α) as well as cell type-specific genes such as Prkcg (PKCγ)31.”

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Authors
Kandel, E. R., Dudai, Y., & Mayford, M. R.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Weizmann Institute of Science (IL)
  • Scripps Research Institute (US)
Corresponding author
Kandel, Eric R.
Venue
Cell
Publisher
Elsevier BV
Published
2014-03
Volume
157
Issue
1
Pages
163-186
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2122682406
Cited by
1,134
References
295
Citations by year
2026: 70 · 2025: 84 · 2024: 105 · 2023: 116 · 2022: 117 · 2021: 115 · 2020: 107 · 2019: 98 · 2018: 85 · 2017: 83 · 2016: 77 · 2015: 60 · 2014: 17
FWCI
7.44
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
memory, learning, memory storage, memory retrieval, memory loss, molecular mechanisms of memory, neural circuits
MeSH terms
Animals, Brain, Humans, Learning, Memory, Neurons, Sleep, Synapses, Systems Biology

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