Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

Luo, G., Ducy, P. F., McKee, M. D., Pinero, G. J., Loyer, E. M., Behringer, R. R., & Karsenty, G. (1997) · Nature · doi:10.1038/386078a0 · Cited by 2,118

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint

Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint

Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856

The Atlas of Mouse Development

Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502

Adipogenesis and Obesity: Rounding Out the Big Picture

Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,262

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127

Connective Tissue and Its Heritable Disorders

Heinegård, D., Aspberg, A., Franzén, A., & Lorenzo, P. (2002) · Wiley eBooks · doi:10.1002/0471221929 · Cited by 946

Bone and haematopoietic defects in mice lacking c-fos

Wang, Z., Ovitt, C. E., Grigoriadis, A. E., Möhle-Steinlein, U., Rüther, U., & Wagner, E. F. (1992) · Nature · doi:10.1038/360741a0 · Cited by 932

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

Johnson, R. S., Spiegelman, B. M., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90592-z · Cited by 636

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

Ogawa, E., Maruyama, M., Kagoshima, H., Inuzuka, M., Lu, J., Satake, M., Shigesada, K., & Ito, Y. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6859 · Cited by 608

Two Distinct Osteoblast-Specific cis-Acting Elements Control Expression of a Mouse Osteocalcin Gene

Ducy, P. F., & Karsenty, G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1858 · Cited by 570

Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.

Molkentin, J. D., & Olson, E. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9366 · Cited by 426

A transcriptional hierarchy involved in mammalian cell-type specification

Kuo, C. J., Conley, P. B., Chen, L., Sladek, F. M., Darnell, J. E., Jr., & Crabtree, G. R. (1992) · Nature · doi:10.1038/355457a0 · Cited by 413

The runt domain identifies a new family of heterometric transcriptional regulators

Kagoshima, H., Shigesada, K., Satake, M., Ito, Y., Miyoshi, H., Ohki, M., Pepling, M., & Gergen, P. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90026-e · Cited by 326

Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy

Goodman, W. G., Ramirez, J. A., Belin, T. R., Chon, Y., Gales, B., Segre, G. V., & Salusky, I. B. (1994) · Kidney International · doi:10.1038/ki.1994.380 · Cited by 318

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

Merriman, H. L., van Wijnen, A. J., Hiebert, S. W., Bidwell, J. P., Fey, E. G., Lian, J. B., Stein, J. L., & Stein, G. S. (1995) · Biochemistry · doi:10.1021/bi00040a025 · Cited by 247

Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1.

Bae, S. C., Yamaguchi‐Iwai, Y., Ogawa, E., Maruyama, M., Inuzuka, M., Kagoshima, H., Shigesada, K., Satake, M., & Ito, Y. (1993) · PubMed · Cited by 228

A PEBP2α/AML-1-related Factor Increases Osteocalcin Promoter Activity through Its Binding to an Osteoblast-specific cis-Acting Element

Geoffroy, V., Ducy, P. F., & Karsenty, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.30973 · Cited by 169

A New Transcription Factor Family Associated with Human Leukemias

Speck, N. A., & Stacy, T. (1995) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v5.i3-4.60 · Cited by 163

Expression of the Runt Domain-Encoding PEBP2 α Genes in T cells during Thymic Development

Satake, M., Nomura, S., Yamaguchi‐Iwai, Y., Takahama, Y., Hashimoto, Y., Niki, M., Kitamura, Y., & Ito, Y. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1662 · Cited by 157

Limbs: a model for pattern formation within the vertebrate body plan

Cohn, M. J., & Tickle, C. A. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10030-5 · Cited by 151

Genetic mapping of cleidocranial dysplasia and evidence of a microdeletion in one family

Mundlos, S., Mulliken, J. B., Abramsom, D. L., Warman, M. L., Knoll, J. H. M., & Olsen, B. R. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.1.71 · Cited by 117

The evolution of genomic imprinting

Chandra, H. S., & Nanjundiah, V. (1990) · Development · doi:10.1242/dev.108.supplement.47 · Cited by 115

1,25-Dihydroxyvitamin D3 Inhibits Osteocalcin Expression in Mouse through an Indirect Mechanism

Zhang, R., Ducy, P. F., & Karsenty, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.110 · Cited by 112

The localized requirements for a gene affecting segmentation in Drosophila: Analysis of larvae mosaic for runt

Gergen, J. P., & Wieschaus, E. F. (1985) · Developmental Biology · doi:10.1016/0012-1606(85)90459-2 · Cited by 109

Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice

Bogdanovic, Z., Bedalov, A., Krebsbach, P. H., Pavlin, D., Woody, C. O., Clark, S. H., Thomas, H. F., Rowe, D. W., Kream, B. E., & Lichtler, A. C. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090218 · Cited by 103

Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts.

Rossert, J., Chen, S. S., Eberspaecher, H., Smith, C. N., & Crombrugghe, B. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1027 · Cited by 102

Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs.

Towler, D. A., Bennett, C. D., & Rodan, G. A. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.5.7914673 · Cited by 98

Expression of runt in the mouse embryo

Simeone, A., Daga, A., & Calabi, F. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030107 · Cited by 73

Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter

Wijmenga, C., Speck, N. A., Dracopoli, N. C., Hofker, M. H., Liu, P., & Collins, F. S. (1995) · Genomics · doi:10.1016/0888-7543(95)80185-o · Cited by 47

Regulation of COL1A1 expression in type I collagen producing tissues: Identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice

Bedalov, A., Salvatori, R., Dodig, M., Kronenberg, M. S., Kapural, B., Bogdanovic, Z., Kream, B. E., Woody, C. O., Clark, S. H., Mack, K., et al. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650101004 · Cited by 46

A ubiquitous repressor interacting with an F9 cell-specific silencer and its functional suppression by differentiated cell-specific positive factors.

Furukawa, K., Yamaguchi, Y., Ogawa, E., Shigesada, K., Satake, M., & Ito, Y. (1990) · PubMed · Cited by 43

Animal model: Skeletal anomalies in mice with cleidocranial dysplasia

Sillence, D. O., Ritchie, H. E., Selby, P. B., & Prieur, D. J. (1987) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320270109 · Cited by 42

Identification of the mouse pro-α1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts

Rossert, J. (1996) · Medical Entomology and Zoology · Cited by 34

Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs

Towler, D. A. (1994) · Molecular Endocrinology · doi:10.1210/me.8.5.614 · Cited by 33

Identification of a minimal sequence of the mouse Pro-α1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts

Rossert, J., Chen, S. S., Nakashima, K., Eberspaecher, H., Smith, C. N., & Crombrugghe, B. D. (1996) · Matrix Biology · doi:10.1016/s0945-053x(96)90093-1 · Cited by 9

Human Adipose Tissue Is a Source of Multipotent Stem Cells

Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762

Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)

Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670

The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation

Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044

Transcriptional regulation of osteoblast differentiation during development

Karsenty, G. (1998) · Frontiers in bioscience · doi:10.2741/a326 · Cited by 39

Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis

Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27

Characterization of Osf1, an Osteoblast-specific Transcription Factor Binding to a Critical cis-acting Element in the MouseOsteocalcin Promoters

Schinke, T., & Karsenty, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30182 · Cited by 73

Mesenchymal Stem Cells and Osteoblast Differentiation

Aubin, J. E., & Triffitt, J. T. (2002) · Elsevier eBooks · doi:10.1016/b978-012098652-1.50106-2 · Cited by 163

The Developmental Control of Osteoblast-Specific Gene Expression: Role of Specific Transcription Factors and the Extracellular Matrix Environment

Franceschi, R. T. (1999) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411990100010201 · Cited by 274