Cited by 4,246Bone Metabolism and DiseasesBone and Dental Protein StudiesDevelopmental Biology and Gene Regulation

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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

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Ducy, Patricia, Zhang, Rui, Geoffroy, Valérie, Ridall, Amy L, Karsenty, Gérard·1997·Cell

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Abstract

The osteoblast is the bone-forming cell. The molecular basis of osteoblast-specific gene expression and differentiation is unknown. We previously identified an osteoblast-specific cis-acting element, termed OSE2, in the Osteocalcin promoter. We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2. Osf2/Cbfa1 expression is initiated in the mesenchymal condensations of the developing skeleton, is strictly restricted to cells of the osteoblast lineage thereafter, and is regulated by BMP7 and vitamin D3. Osf2/Cbfa1 binds to and regulates the expression of multiple genes expressed in osteoblasts. Finally, forced expression of Osf2/Cbfa1 in nonosteoblastic cells induces the expression of the principal osteoblast-specific genes. This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation.

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Otto, F., Thornell, A., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,813
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Self-citation
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint
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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint
Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.
Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G., & Downing, J. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80986-1 · Cited by 1,856
The Atlas of Mouse Development
Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750
Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia
Mundlos, S., Otto, F., Mundlos, C., Mulliken, J. B., Aylsworth, A. S., Albright, S. G., Lindhout, D., Cole, W. G., Henn, W., Knoll, J. H. M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80260-3 · Cited by 1,502
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Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,262
Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint
Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151
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Show all 43 references

Research works printed but not linked: 4

Aubin, J., and Liu, F. (1996). The osteoblast lineage. In Principles of Bone Biology, J.P. Bilezikian, L.G. Raisz, and G.A. Rodan, eds. (San Diego, California: Academic Press), pp. 51–67.
Bae, 1992, Isolation of PEBP2αB cDNA representing the mouse homologue of human acute myeloid leukemia gene, Oncogene, 8, 809
Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, C. Nolan, ed. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
Sundin, 1990, Region-specific expression in early chick and mouse embryo of Ghox-lab and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila labial, Development, 108, 47, 10.1242/dev.108.1.47 · DOI

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Datta, H. K., Ng, W. F., Walker, J. A., Tuck, S. P., & Varanasi, S. S. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048868 · Cited by 614
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Logothetis, C. J., & Lin, S.-H. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1528 · Cited by 629
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
Akiyama, H., Kim, J., Nakashima, K., Balmes, G. C., Iwai, N., Deng, J. M., Zhang, Z., Martin, J. F., Behringer, R. R., Nakamura, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504750102 · Cited by 607
Mitotic Misregulation and Human Aging
Ly, D. H., Lockhart, D. J., Lerner, R. A., & Schultz, P. G. (2000) · Science · doi:10.1126/science.287.5462.2486 · Cited by 599
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
Ivey, K. N., Muth, A. N., Arnold, J., King, F. W., Yeh, R.-F., Fish, J. E., Hsiao, E. C., Schwartz, R. J., Conklin, B. R., Bernstein, H. S., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.01.016 · Cited by 610
The Transcription Factors L-Sox5 and Sox6 Are Essential for Cartilage Formation
Smits, P. J., Li, P., Mandel, J., Zhang, Z., Deng, J. M., Behringer, R. R., Crombrugghe, B. D., & Lefèbvre, V. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00003-x · Cited by 600
Regulatory mechanisms of osteoblast and osteoclast differentiation
Katagiri, T., & Takahashi, N. (2002) · Oral Diseases · doi:10.1034/j.1601-0825.2002.01829.x · Cited by 603
Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation
Li, Z., Hassan, M. Q., Jafferji, M., Aqeilan, R. I., Garzon, R., Croce, C. M., van Wijnen, A. J., Stein, J. L., Stein, G. S., & Lian, J. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809787200 · Cited by 595
Cellular biology of fracture healing
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577
Marrow stromal stem cells.
Bianco, P., & Robey, P. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10413 · Cited by 908
Role and regulation of RUNX2 in osteogenesis
Bruderer, M., Richards, R. G., Alini, M., & Stoddart, M. J. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a19 · Cited by 586
Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton
Baron, R., & Rawadi, G. (2007) · Endocrinology · doi:10.1210/en.2007-0270 · Cited by 584
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
Zhang, X., Schwarz, E. M., Young, D. A., Puzas, J. E., Rosier, R. N., & O’Keefe, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215681 · Cited by 576
Development of the chick olfactory nerve
Vermeer, P. D., & Silverman, A. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199904)214:4 · Cited by 33
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
Lee, B., Thirunavukkarasu, K., Zhou, L., Pastore, L., Baldini, A., Hecht, J. T., Geoffrey, V., Ducy, P. F., & Karsenty, G. (1997) · Nature Genetics · doi:10.1038/ng0797-307 · Cited by 567
Self-citation
Osteoimmunology: Interactions of the Bone and Immune System
Lorenzo, J., Horowitz, M. C., & Choi, Y. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0038 · Cited by 576
Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB
Bai, X., Lu, D., Bai, J., Zheng, H., Ke, Z.-Y., Li, X., & Luo, S.-Q. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.073 · Cited by 571
A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator
Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y., & Ito, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2551 · Cited by 568
Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-α*
Gilbert, L., He, X., Farmer, P., Boden, S., Kozlowski, M., Rubin, J., & Nanes, M. S. (2000) · Endocrinology · doi:10.1210/endo.141.11.7739 · Cited by 555
MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1
Xiao, G., Jiang, D., Thomas, P. E., Benson, M. D., Guan, K., Karsenty, G., & Franceschi, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4453 · Cited by 552
Self-citation
Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
Franceschi, R. T., & Xiao, G. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10369 · Cited by 540
Does adult fracture repair recapitulate embryonic skeletal formation?
Ferguson, C. M., Alpern, E., Miclau, T., & Helms, J. A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00142-2 · Cited by 540
Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
Stein, G. S., Lian, J. B., van Wijnen, A. J., Stein, J. L., Montecino, M. A., Javed, A., Zaidi, S. K., Young, D. W., Choi, J., & Pockwinse, S. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207676 · Cited by 536
Bone Growth Factors
Mohan, S., & Baylink, D. J. (1991) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199102000-00004 · Cited by 529
TGF‐β‐induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
Alliston, T., Choy, L., Ducy, P., Karsenty, G., & Derynck, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2254 · Cited by 526
Self-citation

Authors: Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Karsenty, Gérard
ORCID: Ducy, Patricia
Zhang, Rui
Geoffroy, Valérie
Karsenty, Gérard
Venue: Cell
Publisher: Elsevier BV
Published: 1997-05
Volume: 89
Issue: 5
Pages: 747-754
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(00)80257-3
OpenAlex: W1994596418
Cited by: 4,246
References: 43
Citations by year: 2026: 40 · 2025: 46 · 2024: 59 · 2023: 83 · 2022: 93 · 2021: 106 · 2020: 137 · 2019: 148 · 2018: 123 · 2017: 176 · 2016: 153 · 2015: 175 · 2014: 184 · 2013: 198 · 2012: 198
FWCI: 34.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5921 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE11290, R01DE011290)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: osteogenic differentiation, transcription factors, osteocalcin promoter, osteoblast-specific gene expression, BMP-7, vitamin D3, mesenchymal condensation, skeletal development, osteoblast lineage
MeSH terms: Amino Acid Sequence, Animals, Cell Differentiation, Cloning, Molecular, Molecular Sequence Data, Neoplasm Proteins, Osteoblasts, Promoter Regions, Genetic, Transcription Factors, Trans-Activators, Osteocalcin, Cell Adhesion Molecules, DNA, Complementary, Gene Expression Regulation, Developmental, Core Binding Factor Alpha 1 Subunit, Mice

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Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

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